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ICCB280
🥰Excellent
Catalog No. T8839Cas No. 2041072-41-5
ICCB280 was capable of inducing differentiation and apoptosis of ATRA-resistant patient blasts strongly signify that the activity of this compound can overcome resistance to other current therapies for AML with an unfavorable prognosis.
ICCB280
🥰Excellent
Purity: 98.96%
Catalog No. T8839Cas No. 2041072-41-5
ICCB280 was capable of inducing differentiation and apoptosis of ATRA-resistant patient blasts strongly signify that the activity of this compound can overcome resistance to other current therapies for AML with an unfavorable prognosis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $74 | In Stock | |
| 2 mg | $108 | In Stock | |
| 5 mg | $178 | In Stock | |
| 10 mg | $322 | In Stock | |
| 25 mg | $522 | In Stock | |
| 50 mg | $759 | In Stock | |
| 100 mg | $1,060 | In Stock | |
| 500 mg | $2,130 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $197 | In Stock |
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Purity:98.96%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | ICCB280 was capable of inducing differentiation and apoptosis of ATRA-resistant patient blasts strongly signify that the activity of this compound can overcome resistance to other current therapies for AML with an unfavorable prognosis. |
| Targets&IC50 | Others:8.6 μM |
| In vitro | ICCB280 (10 μM; 2-8 d) increases the C/EBPα expression (mRNA and protein) and modulates its target genes in HL-60 cells.ICCB280 (0.1-50 μM; 48 h) suppresses the HL-60 cell growth, with an IC50 of 8.6 μM[1]. |
| Molecular Weight | 386.4 |
| Formula | C23H18N2O4 |
| Cas No. | 2041072-41-5 |
| Smiles | COc1ccccc1-n1c(\C=C\c2ccc(O)c(O)c2)nc2ccccc2c1=O |
| Relative Density. | 1.28 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 55 mg/mL (142.34 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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