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SU16f
Catalog No. T16947Cas No. 251356-45-3
Alias SU-16F, SU 16F, 3-substituted indolin-2-one 16f
SU16f (3-substituted indolin-2-one 16f) is a potent and selective PDGFRβ inhibitor (IC50s: 10 nM, 140 nM, 2.29 μM for PDGFRβ, PDGFR1, PDGFR2, respectively). Neutralization of PDGFRβ receptor by SU16f blocks the promoting role of GC-MSCs conditioned medium in gastric cancer cell proliferation and migration.
SU16f
Catalog No. T16947Alias SU-16F, SU 16F, 3-substituted indolin-2-one 16fCas No. 251356-45-3
SU16f (3-substituted indolin-2-one 16f) is a potent and selective PDGFRβ inhibitor (IC50s: 10 nM, 140 nM, 2.29 μM for PDGFRβ, PDGFR1, PDGFR2, respectively). Neutralization of PDGFRβ receptor by SU16f blocks the promoting role of GC-MSCs conditioned medium in gastric cancer cell proliferation and migration.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $39 | In Stock | |
| 5 mg | $88 | In Stock | |
| 10 mg | $129 | In Stock | |
| 25 mg | $214 | In Stock | |
| 50 mg | $318 | In Stock | |
| 100 mg | $459 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $99 | In Stock |
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Purity:98.38%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | SU16f (3-substituted indolin-2-one 16f) is a potent and selective PDGFRβ inhibitor (IC50s: 10 nM, 140 nM, 2.29 μM for PDGFRβ, PDGFR1, PDGFR2, respectively). Neutralization of PDGFRβ receptor by SU16f blocks the promoting role of GC-MSCs conditioned medium in gastric cancer cell proliferation and migration. |
| Targets&IC50 | PDGFRβ:10 nM, PDGFR2:140 nM, PDGFR1:2.29 μM |
| In vitro | SU16f (20 μM; for 8 hours) significantly abolishes PDGFRβ activation in SGC-7901 by GC-MSC-CM, inhibits GC-MSC-CM-promoted cell proliferation, downregulates p-AKT, Bcl-xl, and Bcl-2 levels, upregulates Bax expression, and modulates E-cadherin, N-cadherin, Vimentin, and α-SMA levels in SGC-7901 cells [1]. |
| Alias | SU-16F, SU 16F, 3-substituted indolin-2-one 16f |
| Molecular Weight | 386.44 |
| Formula | C24H22N2O3 |
| Cas No. | 251356-45-3 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 25 mg/mL (64.69 mM)  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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