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Cirsiliol is a 5-lipoxygenase (5-LOX) inhibitor and low affinity benzodiazepine receptor ligand.Cirsiliol inhibits cell proliferation and promotes apoptosis of OS cells.Cirsiliol shows antitumor activity against OS cells in an in situ xenograft tumor model and can be used to study colon cancer.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $55 | In Stock | |
5 mg | $99 | In Stock | |
10 mg | Inquiry | In Stock |
Description | Cirsiliol is a 5-lipoxygenase (5-LOX) inhibitor and low affinity benzodiazepine receptor ligand.Cirsiliol inhibits cell proliferation and promotes apoptosis of OS cells.Cirsiliol shows antitumor activity against OS cells in an in situ xenograft tumor model and can be used to study colon cancer. |
In vitro | Cirsiliol (0.01- 300 μM) causes concentration-dependent relaxation of rat-isolated ileum. Cirsiliol may inhibit Ca2+ influx but stimulates Ca2+ release from intracellular stores.[1] Treatment with Cirsiliol reduces the proliferation of NSCLC cells through the suppression of radiation-induced Notch-1 expression.[2] |
In vivo | Cirsiliol can act as promising radiosensitizers that enhance the radiotherapeutic efficacy by inhibiting radiation-induced Notch-1 signaling associated with radioresistance possibly via miR-34a-mediated pathways.[2] |
Molecular Weight | 330.29 |
Formula | C17H14O7 |
Cas No. | 34334-69-5 |
Smiles | COc1cc2oc(cc(=O)c2c(O)c1OC)-c1ccc(O)c(O)c1 |
Relative Density. | 1.483 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 25 mg/mL (75.69 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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