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Crebanine

🥰Excellent
Catalog No. T2S2215Cas No. 25127-29-1

1. Crebanine iv 5mg/kg can eonvert BaCl_2-induced arrhythmia into sinus rhythm in rats, and can significantly increase the tolerant dose of aconitine to produce ventrieular fibrillation(VF) and cardiac arrest (CA) in rata. 2. Crebanine can also decrease the incidence of VF and CA by CaCl_2 in rats and by chloroform in mice, but has no proteetive effects on ouahain-indueed arrhythmias in guinea pigs. 3. Crebanine has potential utility of crebanine in the development of neurodegenerative therapy, might be used as the starting point to develop a drug for Alzheimer's disease. 4. Crebanine has anti-cancer activity, can inhibit the proliferation of human leukemic cells (HL-6, U937 and K562), human fibrosarcoma cells (HT18) and cervix cancer cell lines (KB-3-1 and KB-V1; it mediates cell cycle arrest at G/G1 phase and this was associated with down-regulation of cyclins A and D.

Crebanine

Crebanine

🥰Excellent
Purity: 99.65%
Catalog No. T2S2215Cas No. 25127-29-1
1. Crebanine iv 5mg/kg can eonvert BaCl_2-induced arrhythmia into sinus rhythm in rats, and can significantly increase the tolerant dose of aconitine to produce ventrieular fibrillation(VF) and cardiac arrest (CA) in rata. 2. Crebanine can also decrease the incidence of VF and CA by CaCl_2 in rats and by chloroform in mice, but has no proteetive effects on ouahain-indueed arrhythmias in guinea pigs. 3. Crebanine has potential utility of crebanine in the development of neurodegenerative therapy, might be used as the starting point to develop a drug for Alzheimer's disease. 4. Crebanine has anti-cancer activity, can inhibit the proliferation of human leukemic cells (HL-6, U937 and K562), human fibrosarcoma cells (HT18) and cervix cancer cell lines (KB-3-1 and KB-V1; it mediates cell cycle arrest at G/G1 phase and this was associated with down-regulation of cyclins A and D.
Pack SizePriceAvailabilityQuantity
1 mg$44In Stock
5 mg$96In Stock
10 mg$165In Stock
25 mg$319In Stock
50 mg$479In Stock
100 mg$688In Stock
500 mg$1,420In Stock
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Purity:99.65%
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Product Introduction

Bioactivity
Description
1. Crebanine iv 5mg/kg can eonvert BaCl_2-induced arrhythmia into sinus rhythm in rats, and can significantly increase the tolerant dose of aconitine to produce ventrieular fibrillation(VF) and cardiac arrest (CA) in rata. 2. Crebanine can also decrease t
Chemical Properties
Molecular Weight339.39
FormulaC20H21NO4
Cas No.25127-29-1
Smiles[H][C@]12Cc3c(OC)c(OC)ccc3-c3c4OCOc4cc(CCN1C)c23
Relative Density.1.266g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 11 mg/mL (32.41 mM), Sonication is recommended.
Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.9465 mL14.7323 mL29.4646 mL147.3231 mL
5 mM0.5893 mL2.9465 mL5.8929 mL29.4646 mL
10 mM0.2946 mL1.4732 mL2.9465 mL14.7323 mL
20 mM0.1473 mL0.7366 mL1.4732 mL7.3662 mL

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