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Pimonidazole hydrochloride

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Catalog No. T16536Cas No. 70132-51-3

Pimonidazole hydrochloride accumulates in hypoxic cells via covalent binding with macromolecules or by forming reductive metabolites after the reduction of its nitro group. It can be used for qualitative and quantitative assessment of tumor hypoxia. Pimonidazole hydrochloride is a novel hypoxia marker for the complementary study of tumor hypoxia and cell proliferation in tumors.

Pimonidazole hydrochloride

Pimonidazole hydrochloride

🥰Excellent
Purity: 100%
Catalog No. T16536Cas No. 70132-51-3
Pimonidazole hydrochloride accumulates in hypoxic cells via covalent binding with macromolecules or by forming reductive metabolites after the reduction of its nitro group. It can be used for qualitative and quantitative assessment of tumor hypoxia. Pimonidazole hydrochloride is a novel hypoxia marker for the complementary study of tumor hypoxia and cell proliferation in tumors.
Pack SizePriceAvailabilityQuantity
10 mg$41In Stock
25 mg$88In Stock
50 mg$166In Stock
100 mg$287In Stock
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Purity:100%
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Product Introduction

Bioactivity
Description
Pimonidazole hydrochloride accumulates in hypoxic cells via covalent binding with macromolecules or by forming reductive metabolites after the reduction of its nitro group. It can be used for qualitative and quantitative assessment of tumor hypoxia. Pimonidazole hydrochloride is a novel hypoxia marker for the complementary study of tumor hypoxia and cell proliferation in tumors.
In vitro
Pimonidazole, the exogenous hypoxia marker, is a 2-nitroimidazole compound, which forms covalent bonds with cellular macromolecules at oxygen levels below 1.3%[3].
In vivo
Pimonidazole is a 2-nitroimidazole that is reductively activated specifically in hypoxic cells and forms stable adducts with thiol groups in proteins, peptides, and amino acids. Additionally, the amount of pimonidazole that is detected is directly proportional to the level of hypoxia within tumors in vivo.
Chemical Properties
Molecular Weight290.75
FormulaC11H19ClN4O3
Cas No.70132-51-3
SmilesCl.OC(CN1CCCCC1)Cn1ccnc1[N+]([O-])=O
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 30 mg/mL (103 mM), Sonification is recommended.
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM3.4394 mL17.1969 mL34.3938 mL171.9690 mL
5 mM0.6879 mL3.4394 mL6.8788 mL34.3938 mL
10 mM0.3439 mL1.7197 mL3.4394 mL17.1969 mL
20 mM0.1720 mL0.8598 mL1.7197 mL8.5985 mL
50 mM0.0688 mL0.3439 mL0.6879 mL3.4394 mL
100 mM0.0344 mL0.1720 mL0.3439 mL1.7197 mL

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