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Monascuspiloin
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Catalog No. T36991Cas No. 1011244-19-1
Alias Monascinol
Monascuspiloin (Monascinol), a compound extracted from rice fermented with Rhodobacter sphaeroides, exhibits antiandrogenic and antitumor activity and inhibits the proliferation of PC-3 and LNCaP.Monascuspiloin improves lipid metabolism and hepatic function in over-alcohol-addicted mice by decreasing hepatic MDA levels and increasing hepatic CAT, SOD and GSH levels.Monascuspiloin has been shown to improve lipid metabolism and hepatic function in over-alcoholized mice. Monascuspiloin regulates the transcription and protein expression of genes related to hepatic lipid metabolism and oxidative stress, and can be used to study alcohol-induced liver injury.
Monascuspiloin
😃Good
Catalog No. T36991Alias MonascinolCas No. 1011244-19-1
Monascuspiloin (Monascinol), a compound extracted from rice fermented with Rhodobacter sphaeroides, exhibits antiandrogenic and antitumor activity and inhibits the proliferation of PC-3 and LNCaP.Monascuspiloin improves lipid metabolism and hepatic function in over-alcohol-addicted mice by decreasing hepatic MDA levels and increasing hepatic CAT, SOD and GSH levels.Monascuspiloin has been shown to improve lipid metabolism and hepatic function in over-alcoholized mice. Monascuspiloin regulates the transcription and protein expression of genes related to hepatic lipid metabolism and oxidative stress, and can be used to study alcohol-induced liver injury.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μg | $428 | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Monascuspiloin (Monascinol), a compound extracted from rice fermented with Rhodobacter sphaeroides, exhibits antiandrogenic and antitumor activity and inhibits the proliferation of PC-3 and LNCaP.Monascuspiloin improves lipid metabolism and hepatic function in over-alcohol-addicted mice by decreasing hepatic MDA levels and increasing hepatic CAT, SOD and GSH levels.Monascuspiloin has been shown to improve lipid metabolism and hepatic function in over-alcoholized mice. Monascuspiloin regulates the transcription and protein expression of genes related to hepatic lipid metabolism and oxidative stress, and can be used to study alcohol-induced liver injury. |
| Targets&IC50 | LNCaP cells:47 μM, PC-3 cells:45 μM |
| In vitro | Monascuspiloin is an anti-androgenic compound with an IC50 value of 7 μM, which inhibits the viability of PC-3 and LNCaP cells, with IC50 values of 45 μM and 47 μM, respectively.Monascuspiloin induces apoptosis of LNCaP cells through inhibition of Akt/mTOR signaling and autophagy through activation of the AMPK signaling pathway. apoptosis by inhibiting the Akt/mTOR signaling pathway and induced autophagy by activating the AMPK signaling pathway. In addition, Monascuspiloin was able to arrest the PC-3 cell cycle in G2/M phase. [1][2] |
| In vivo | In a mouse model, Monascuspiloin showed significant anti-tumor effects. [2] |
| Alias | Monascinol |
| Molecular Weight | 360.44 |
| Formula | C21H28O5 |
| Cas No. | 1011244-19-1 |
| Smiles | C[C@]12[C@@]([C@@H]([C@H](CCCCC)O)C(=O)O1)(CC3=C(C2=O)COC(/C=C/C)=C3)[H] |
Storage & Solubility Information
| Storage | keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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