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Apicidin
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Apicidin
Catalog No. T14305Cas No. 183506-66-3
Apicidin (OSI 2040) is a histone deacetylase (HDAC) inhibitor with antiparasitic activity and antiproliferative activity.Apicidin attenuates memory deficits, inhibits cell growth and proliferation, and induces apoptosis and autophagy by decreasing Abeta load in APP/PS1 mice, and can be used to study leukemia.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $299 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Apicidin (OSI 2040) is a histone deacetylase (HDAC) inhibitor with antiparasitic activity and antiproliferative activity.Apicidin attenuates memory deficits, inhibits cell growth and proliferation, and induces apoptosis and autophagy by decreasing Abeta load in APP/PS1 mice, and can be used to study leukemia. |
| In vitro | Apicidin (0.1-10 μM, 24 h) inhibits the viability of AT-84 cells in a dose-dependent manner, with concentrations ≥1 μM leading to a significant decrease in viability[1]. |
| In vivo | In the mouse tumor model, at the end of 14 days, Apicidin (5 mg/kg, intraperitoneal injection, once daily) significantly inhibited tumor growth by up to 46% compared to the control group[1]. |
| Alias | OSI 2040 |
| Molecular Weight | 623.78 |
| Formula | C34H49N5O6 |
| Cas No. | 183506-66-3 |
| Storage | store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||
| Solubility Information | DMSO: 10 mg/mL (16.03 mM) | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
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