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Bromoenol lactone
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Bromoenol lactone
Catalog No. T14829Cas No. 88070-98-8
Bromoenol lactone is a suicide-based irreversible, selective, potent inhibitor of calcium-independent phospholipase A2 (iPLA2β; IC50: ~7 μM). It inhibits antigen-stimulated mast cell exocytosis without blocking Ca2+ influx.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mL x 10 mM (in DMSO) | $162 | 7-10 days |
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Bromoenol lactone is a suicide-based irreversible, selective, potent inhibitor of calcium-independent phospholipase A2 (iPLA2β; IC50: ~7 μM). It inhibits antigen-stimulated mast cell exocytosis without blocking Ca2+ influx. |
| In vitro | Bromoenol lactone inhibits exocytosis when stimulated using a Ca2+ ionophore A23187, which passively transports Ca2+ down a concentration gradient and also in permeabilized mast cells where Ca2+ entry is no longer relevant. In RBL 2H3 and bone marrow-derived mast cells (BMMCs), Ca2+ entry is critical for exocytosis. Moreover, Bromoenol lactone has only a minor effect on antigen- or thapsigargin-stimulated Ca2+ signaling, both the release from internal stores and sustained elevation due to Ca2+ influx [1]. |
| Alias | (6E)-Bromoenol lactone |
| Molecular Weight | 317.18 |
| Formula | C16H13BrO2 |
| Cas No. | 88070-98-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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