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1-Octadecyl Lysophosphatidic Acid

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Catalog No. T36768Cas No. 52977-29-4

1-Octadecyl lysophosphatidic acid (1-octadecyl LPA) is a LPA analog containing stearic acid at the sn-1 position. LPA binds to one of five different G protein linked receptors to mediate a variety of biological responses including cell proliferation, smooth muscle contraction, platelet aggregation, neurite retraction, and cell motility. Alkyl ether-linked LPA derivatives have a higher platelet aggregating activity than the acyl derivatives, most likely stemming from an alkyl-specific LPA receptor. For example, 1-octadecyl LPA has a platelet aggregating EC50 value of 9 nM versus 1-octadecanoyl LPA which has an EC50 value of 177 nM.

1-Octadecyl Lysophosphatidic Acid

1-Octadecyl Lysophosphatidic Acid

😃Good
Catalog No. T36768Cas No. 52977-29-4
1-Octadecyl lysophosphatidic acid (1-octadecyl LPA) is a LPA analog containing stearic acid at the sn-1 position. LPA binds to one of five different G protein linked receptors to mediate a variety of biological responses including cell proliferation, smooth muscle contraction, platelet aggregation, neurite retraction, and cell motility. Alkyl ether-linked LPA derivatives have a higher platelet aggregating activity than the acyl derivatives, most likely stemming from an alkyl-specific LPA receptor. For example, 1-octadecyl LPA has a platelet aggregating EC50 value of 9 nM versus 1-octadecanoyl LPA which has an EC50 value of 177 nM.
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Product Introduction

Bioactivity
Description
1-Octadecyl lysophosphatidic acid (1-octadecyl LPA) is a LPA analog containing stearic acid at the sn-1 position. LPA binds to one of five different G protein linked receptors to mediate a variety of biological responses including cell proliferation, smooth muscle contraction, platelet aggregation, neurite retraction, and cell motility. Alkyl ether-linked LPA derivatives have a higher platelet aggregating activity than the acyl derivatives, most likely stemming from an alkyl-specific LPA receptor. For example, 1-octadecyl LPA has a platelet aggregating EC50 value of 9 nM versus 1-octadecanoyl LPA which has an EC50 value of 177 nM.
Chemical Properties
Molecular Weight424.559
FormulaC21H45O6P
Cas No.52977-29-4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 10 mg/mL (23.55 mM), Sonication is recommended.
Ethanol: 10 mg/mL (23.55 mM), Sonication is recommended.
Ethanol:PBS (pH 7.2) ((1:1): 0.5 mg/mL (1.18 mM), Sonication is recommended.
DMF: 10 mg/mL (23.55 mM), Sonication is recommended.
Solution Preparation Table
DMSO/Ethanol/DMF
1mg5mg10mg50mg
5 mM0.4711 mL2.3554 mL4.7108 mL23.5539 mL
10 mM0.2355 mL1.1777 mL2.3554 mL11.7769 mL
20 mM0.1178 mL0.5888 mL1.1777 mL5.8885 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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Keywords

1 Octadecyl Lysophosphatidic Acid1Octadecyl Lysophosphatidic Acid1-Octadecyl Lysophosphatidic Acid
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