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AD1058

🥰Excellent
Catalog No. T200105Cas No. 2907782-78-7
Alias AD 1058

AD1058 is a potent and selective ATR inhibitor (IC50 = 1.6 nM) that crosses the blood-brain barrier with significant in vivo anticancer activity. It is commonly used in the study of brain metastasis and CNS metastasis by inhibiting cell proliferation, disrupting the cell cycle and inducing apoptosis.

AD1058

AD1058

🥰Excellent
Purity: 98.24%
Catalog No. T200105Alias AD 1058Cas No. 2907782-78-7
AD1058 is a potent and selective ATR inhibitor (IC50 = 1.6 nM) that crosses the blood-brain barrier with significant in vivo anticancer activity. It is commonly used in the study of brain metastasis and CNS metastasis by inhibiting cell proliferation, disrupting the cell cycle and inducing apoptosis.
Pack SizePriceAvailabilityQuantity
25 mg$1,520In Stock
50 mg$1,980In Stock
100 mg$2,500In Stock
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Purity:98.24%
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Product Introduction

Bioactivity
Description
AD1058 is a potent and selective ATR inhibitor (IC50 = 1.6 nM) that crosses the blood-brain barrier with significant in vivo anticancer activity. It is commonly used in the study of brain metastasis and CNS metastasis by inhibiting cell proliferation, disrupting the cell cycle and inducing apoptosis.
Targets&IC50
ATR:1.6 nM, ARK5:7314.00 nM, LCK:2594.00 nM, mTOR:45.83 nM
AliasAD 1058
Chemical Properties
Molecular Weight412.47
FormulaC19H20N6O3S
Cas No.2907782-78-7
SmilesC[C@H]1N(C2=C3C(=NC(=N2)C4=C5C(=NC=C4)NC=C5)N(S(C)(=O)=O)C=C3)CCOC1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 80 mg/mL (193.95 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4244 mL12.1221 mL24.2442 mL121.2209 mL
5 mM0.4849 mL2.4244 mL4.8488 mL24.2442 mL
10 mM0.2424 mL1.2122 mL2.4244 mL12.1221 mL
20 mM0.1212 mL0.6061 mL1.2122 mL6.0610 mL
50 mM0.0485 mL0.2424 mL0.4849 mL2.4244 mL
100 mM0.0242 mL0.1212 mL0.2424 mL1.2122 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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