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AD1058 is a potent and selective ATR inhibitor (IC50 = 1.6 nM) that crosses the blood-brain barrier with significant in vivo anticancer activity. It is commonly used in the study of brain metastasis and CNS metastasis by inhibiting cell proliferation, disrupting the cell cycle and inducing apoptosis.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,520 | In Stock | |
50 mg | $1,980 | In Stock | |
100 mg | $2,500 | In Stock |
Description | AD1058 is a potent and selective ATR inhibitor (IC50 = 1.6 nM) that crosses the blood-brain barrier with significant in vivo anticancer activity. It is commonly used in the study of brain metastasis and CNS metastasis by inhibiting cell proliferation, disrupting the cell cycle and inducing apoptosis. |
Targets&IC50 | ATR:1.6 nM, ARK5:7314.00 nM, LCK:2594.00 nM, mTOR:45.83 nM |
Alias | AD 1058 |
Molecular Weight | 412.47 |
Formula | C19H20N6O3S |
Cas No. | 2907782-78-7 |
Smiles | C[C@H]1N(C2=C3C(=NC(=N2)C4=C5C(=NC=C4)NC=C5)N(S(C)(=O)=O)C=C3)CCOC1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 80 mg/mL (193.95 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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