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PI3K/Akt/CREB activator 1
🥰Excellent
Catalog No. T72227Cas No. 2708177-73-3
PI3K/Akt/CREB activator 1 (AE-18) is a selective inducible nitric oxide synthase (iNOS) inhibitor that crosses the blood-brain barrier, reduces infarct size and restores blood supply deficits after ischemia-reperfusion in rats, and is used in studies of vascular dementia and Parkinson's disease.
PI3K/Akt/CREB activator 1
🥰Excellent
Catalog No. T72227Cas No. 2708177-73-3
PI3K/Akt/CREB activator 1 (AE-18) is a selective inducible nitric oxide synthase (iNOS) inhibitor that crosses the blood-brain barrier, reduces infarct size and restores blood supply deficits after ischemia-reperfusion in rats, and is used in studies of vascular dementia and Parkinson's disease.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $67 | In Stock |
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Product Introduction
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Chemical Properties
| Description | PI3K/Akt/CREB activator 1 (AE-18) is a selective inducible nitric oxide synthase (iNOS) inhibitor that crosses the blood-brain barrier, reduces infarct size and restores blood supply deficits after ischemia-reperfusion in rats, and is used in studies of vascular dementia and Parkinson's disease. |
| In vitro | PI3K/Akt/CREB activator 1 (Compound AE-18) (10 and 20 μM; 48 hr treatment) enhances BDNF expression in Neuro-2a cells through activation of the PI3K/Akt/CREB pathway, which promotes the formation of neurites and cell proliferation. Treatment of neurons with 10 and 20 μM PI3K/Akt/CREB activator 1 enhances the differentiation of cultured hippocampal neurons and promotes axonal and dendritic polarity formation through the PI3K/Akt signaling pathway. [1] |
| In vivo | In male Sprague-Dawley rats in a chronic cerebral hypoperfusion (CCH) model, gavage of 5 and 10 mg/kg PI3K/Akt/CREB activator 1 promoted the recovery of cerebral blood flow (CBF) after bilateral common carotid artery ligation (BCCAO). PI3K/Akt/CREB activator 1 (5 and 10 mg/kg; by gavage; for 5 consecutive days) attenuated learning and memory impairments in a rat model of CCH, while alleviating hippocampal pathology damage caused by BCCAO. [1] |
| Molecular Weight | 381.32 |
| Formula | C19H15F4NO3 |
| Cas No. | 2708177-73-3 |
| Smiles | C([C@H](NC(/C=C/C1=CC=C(C(F)(F)F)C=C1)=O)C(O)=O)C2=CC=C(F)C=C2 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 200.00 mg/mL (524.49 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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