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Y134
🥰Excellent
Catalog No. T23540Cas No. 849662-80-2
Alias Y 134
Y134 is an estrogen receptor inhibitor that is selective and orally active, exhibiting strong antagonist activity against ERα and Erβ with Ki of 0.09 nM and 11.31 nM, respectively. The selectivity of Y134 for ERα is 121.1 times higher than that for ERβ. Y134 inhibited the proliferation of ER positive human breast cancer cells stimulated by estrogen.
Y134
🥰Excellent
Purity: 99.72%
Catalog No. T23540Alias Y 134Cas No. 849662-80-2
Y134 is an estrogen receptor inhibitor that is selective and orally active, exhibiting strong antagonist activity against ERα and Erβ with Ki of 0.09 nM and 11.31 nM, respectively. The selectivity of Y134 for ERα is 121.1 times higher than that for ERβ. Y134 inhibited the proliferation of ER positive human breast cancer cells stimulated by estrogen.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $64 | In Stock | |
| 5 mg | $156 | In Stock | |
| 10 mg | $255 | In Stock | |
| 25 mg | $513 | In Stock | |
| 50 mg | $768 | In Stock | |
| 100 mg | $1,230 | In Stock | |
| 200 mg | $1,670 | In Stock |
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Purity:99.72%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Y134 is an estrogen receptor inhibitor that is selective and orally active, exhibiting strong antagonist activity against ERα and Erβ with Ki of 0.09 nM and 11.31 nM, respectively. The selectivity of Y134 for ERα is 121.1 times higher than that for ERβ. Y134 inhibited the proliferation of ER positive human breast cancer cells stimulated by estrogen. |
| Targets&IC50 | ERβ:11.31 nM (Ki), ERα:0.09 nM (Ki) |
| In vitro | Y134 displays robust antagonistic effects on estrogen receptors (ERs) in CV-1 cells co-transfected with plasmids carrying ERα or ERβ along with estrogen-response element-driven luciferase, resulting in a significant decrease in luciferase activity.[1] Treatment with Y134 (0.01 nM-10 μM; 6 d) effectively suppresses the proliferation of ER-expressing breast cancer cells (MCF-7 and T47D) stimulated by estrogen.[1] |
| In vivo | Administration of Y134 (1-3 mg/kg/day; p.o. for 3 days) completely eliminates the estrogen-induced growth of terminal end buds (TEB) in the mammary glands of ovariectomized rats. Y134 exhibits a dose-dependent inhibition of uterine cell proliferation induced by estrogen (E2). [1] |
| Alias | Y 134 |
| Molecular Weight | 472.6 |
| Formula | C28H28N2O3S |
| Cas No. | 849662-80-2 |
| Smiles | C(=O)(C1=C(SC=2C1=CC=C(O)C2)C3=CC=C(O)C=C3)C4=CC=C(C=C4)N5CCN(C(C)C)CC5 |
| Relative Density. | 1.282g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 47.26 mg/mL (90.0 mM) Ethanol: 47.26 mg/mL (90.0 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO/Ethanol
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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