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BTT-3033

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Purity:98.91%

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COA HPLC HNMR

BTT-3033

Catalog No. T26917Cas No. 1259028-99-3

BTT-3033 is an orally active and potent α2β1 (EC50: 130 nM) inhibitor with an EC50 value of 130 nM. BTT-3033 has an affinity for the α2I domain and inhibits platelet binding to collagen I and cell proliferation.BTT-3033 induces apoptosis and can be used in the study of prostate cancer, BTT-3033 induces apoptosis and can be used to study prostate cancer, inflammation and cardiovascular disease.

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Pack Size	Price	Availability
5 mg	$108	In Stock
10 mg	$158	In Stock
25 mg	$266	In Stock
50 mg	$395	In Stock

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Product Introduction

Bioactivity

Description	BTT-3033 is an orally active and potent α2β1 (EC50: 130 nM) inhibitor with an EC50 value of 130 nM. BTT-3033 has an affinity for the α2I domain and inhibits platelet binding to collagen I and cell proliferation.BTT-3033 induces apoptosis and can be used in the study of prostate cancer, BTT-3033 induces apoptosis and can be used to study prostate cancer, inflammation and cardiovascular disease.
In vitro	BTT-3033 and BTT-3034 inhibited cell adhesion to rat tail collagen I with EC50 values of 130 and 160 nM, respectively, and corresponding Emax values of 97 and 86% .Neither BTT-3033 nor BTT-3034 (at EC50 concentrations) inhibited the adhesion of MG-63 cells to vitronectin, 120-kDa fibronectin or 40-kDa fibronectin, assays that measured αV, α5β1, and α4β1 integrin function, respectively [2].
In vivo	Integrin α2β1 function blocking sulfonamides BTT-3016, BTT-3033(oral administration, 10 mg/kg) and BTT-3034 have anti-inflammatory effects in PAF-stimulated air pouch model[1].
Alias	BTT3033, BTT 3033

Chemical Properties

Molecular Weight	465.5
Formula	C23H20FN5O3S
Cas No.	1259028-99-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (214.82 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1482 mL	10.7411 mL	21.4823 mL	107.4114 mL
5 mM	0.4296 mL	2.1482 mL	4.2965 mL	21.4823 mL
10 mM	0.2148 mL	1.0741 mL	2.1482 mL	10.7411 mL
20 mM	0.1074 mL	0.5371 mL	1.0741 mL	5.3706 mL
50 mM	0.0430 mL	0.2148 mL	0.4296 mL	2.1482 mL
100 mM	0.0215 mL	0.1074 mL	0.2148 mL	1.0741 mL

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