Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

BTT-3033

🥰Excellent
Catalog No. T26917Cas No. 1259028-99-3
Alias BTT3033, BTT 3033

BTT-3033 is an orally active and potent α2β1 (EC50: 130 nM) inhibitor with an affinity for the α2I domain, inhibiting platelet binding to collagen I and cell proliferation. BTT-3033 induces apoptosis and can be used to study prostate cancer, inflammation, and cardiovascular disease.

BTT-3033

BTT-3033

🥰Excellent
Purity: 98.91%
Catalog No. T26917Alias BTT3033, BTT 3033Cas No. 1259028-99-3
BTT-3033 is an orally active and potent α2β1 (EC50: 130 nM) inhibitor with an affinity for the α2I domain, inhibiting platelet binding to collagen I and cell proliferation. BTT-3033 induces apoptosis and can be used to study prostate cancer, inflammation, and cardiovascular disease.
Pack SizePriceAvailabilityQuantity
5 mg$108In Stock
10 mg$158In Stock
25 mg$266In Stock
50 mg$395In Stock
Bulk & Custom
Add to Cart
Questions
View More

Related Compound Libraries of "BTT-3033"

Select Batch
Purity:98.91%
Contact us for more batch information
Resource Download
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity
Description
BTT-3033 is an orally active and potent α2β1 (EC50: 130 nM) inhibitor with an affinity for the α2I domain, inhibiting platelet binding to collagen I and cell proliferation. BTT-3033 induces apoptosis and can be used to study prostate cancer, inflammation, and cardiovascular disease.
Targets&IC50
α2β1:130 nM (EC50)
In vitro
BTT-3033 and BTT-3034 inhibited cell adhesion to rat tail collagen I with EC50 values of 130 and 160 nM, respectively, and corresponding Emax values of 97 and 86% .Neither BTT-3033 nor BTT-3034 (at EC50 concentrations) inhibited the adhesion of MG-63 cells to vitronectin, 120-kDa fibronectin or 40-kDa fibronectin, assays that measured αV, α5β1, and α4β1 integrin function, respectively [2].
In vivo
Integrin α2β1 function blocking sulfonamides BTT-3016, BTT-3033(oral administration, 10 mg/kg) and BTT-3034 have anti-inflammatory effects in PAF-stimulated air pouch model[1].
AliasBTT3033, BTT 3033
Chemical Properties
Molecular Weight465.5
FormulaC23H20FN5O3S
Cas No.1259028-99-3
SmilesCN(c1ccc(NC(=O)Nc2ccccc2)cc1)S(=O)(=O)c1cnn(c1)-c1ccc(F)cc1
Relative Density.1.35 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 100 mg/mL (214.82 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1482 mL10.7411 mL21.4823 mL107.4114 mL
5 mM0.4296 mL2.1482 mL4.2965 mL21.4823 mL
10 mM0.2148 mL1.0741 mL2.1482 mL10.7411 mL
20 mM0.1074 mL0.5371 mL1.0741 mL5.3706 mL
50 mM0.0430 mL0.2148 mL0.4296 mL2.1482 mL
100 mM0.0215 mL0.1074 mL0.2148 mL1.0741 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
%Tween 80
%ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Related Tags: buy BTT-3033 | purchase BTT-3033 | BTT-3033 cost | order BTT-3033 | BTT-3033 chemical structure | BTT-3033 in vivo | BTT-3033 in vitro | BTT-3033 formula | BTT-3033 molecular weight