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SR-31747

Catalog No. T16926Cas No. 132173-07-0

SR-31747 blocks cell proliferation by inhibiting sterol isomerase. SR-31747 is a sigma ligand. It has immunosuppressive and anti-inflammatory properties.

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Pack Size	Price	Availability
5 mg	$297	6-8 weeks
25 mg	$987	6-8 weeks
50 mg	$1,360	6-8 weeks
100 mg	$1,860	6-8 weeks
1 mL x 10 mM (in DMSO)	$299	6-8 weeks

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Product Introduction

Bioactivity

Description	SR-31747 blocks cell proliferation by inhibiting sterol isomerase. SR-31747 is a sigma ligand. It has immunosuppressive and anti-inflammatory properties.
In vitro	SR-31747 (10 nM) blocks the proliferation of lymphocytes at a concentration. SR-31747 arrests proliferation in yeast cells in a dose-dependent manner. SR-31747 is capable of inhibiting T-cell proliferation when added as late as 24 h after activation [2].
In vivo	SR-31747 dramatically blocks lipopolysaccharide-induced production of IL-1, IL-6, and TNF-α in a dose-dependent manner (ED50: 2 mg/kg) in vivo. SR-31747 probably abrogated monokine production through an indirect mechanism that involves endogenous corticosteroids. Ablation of corticosteroids by the use of Mifepristone or adrenalectomy suppresses the effect of SR-31747. Administration of SR-31747 induces an enhancement of the corticosterone level. SR-31747 improves the survival of animals with endotoxic shock as a result of monokine inhibition [1].

Chemical Properties

Molecular Weight	396.44
Formula	C23H35Cl2N
Cas No.	132173-07-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 15.62 mg/mL (39.40 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5224 mL	12.6122 mL	25.2245 mL	126.1225 mL
5 mM	0.5045 mL	2.5224 mL	5.0449 mL	25.2245 mL
10 mM	0.2522 mL	1.2612 mL	2.5224 mL	12.6122 mL
20 mM	0.1261 mL	0.6306 mL	1.2612 mL	6.3061 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc