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GSK2194069 is an active β-keto reductase (KR)-specific inhibitor of fatty acid synthase (FASN) with an IC50 of 7.7 nM in an assay for the detection of released CoA.GSK2194069 inhibits the proliferation of FAS in cancer cells through the action of acetoacetyl-coenzyme A and NADPH.
Pack Size | Price | Availability | Quantity |
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2 mg | $149 | In Stock |
Description | GSK2194069 is an active β-keto reductase (KR)-specific inhibitor of fatty acid synthase (FASN) with an IC50 of 7.7 nM in an assay for the detection of released CoA.GSK2194069 inhibits the proliferation of FAS in cancer cells through the action of acetoacetyl-coenzyme A and NADPH. |
Targets&IC50 | β-ketoyl reductase:7.7 nM, Phosphatidylcholine:15.5 ± 9 nM(EC50) |
In vitro | GSK2194069 (100 nM; 24 h) suppresses fatty acid synthase (FAS) activity in cancer cell lines (KATO-III, MKN45, A549, SNU-1) while maintaining FAS protein production levels.[1] GSK2194069 (5 μM and 20 μM) demonstrates higher efficacy in FASN-positive LNCaP cells compared to FASN-negative PC3 cells, correlating with higher FASN expression in LNCaP cells.[2] GSK2194069 (50 μM; 24 h) inhibits the growth of LNCaP-LN3 human prostate cancer cells.[3] GSK2194069 (60.4 nM; 24 h) exhibits metabolomic alterations, including decreases in L-acetyl carnitine, stearoyl carnitine, vaccenyl carnitine, and palmitoyl-L-carnitine in LNCaP-LN3 cells.[3] |
Molecular Weight | 428.48 |
Formula | C25H24N4O3 |
Cas No. | 1332331-08-4 |
Smiles | O=C(C1CC1)N1CC[C@@H](Cc2n[nH]c(=O)n2-c2ccc(cc2)-c2ccc3occc3c2)C1 |
Relative Density. | 1.44 g/cm3 (Predicted) |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 90.0 mg/mL (210.0 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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