Shopping Cart
- Remove All
Your shopping cart is currently empty
GSK2194069
GSK2194069 is an active β-keto reductase (KR)-specific inhibitor of fatty acid synthase (FASN) with an IC50 of 7.7 nM in an assay for the detection of released CoA.GSK2194069 inhibits the proliferation of FAS in cancer cells through the action of acetoacetyl-coenzyme A and NADPH.
Catalog No. T15429Cas No. 1332331-08-4
Select Batch
Purity:99.84%
Contact us for more batch information
GSK2194069
Catalog No. T15429Cas No. 1332331-08-4
GSK2194069 is an active β-keto reductase (KR)-specific inhibitor of fatty acid synthase (FASN) with an IC50 of 7.7 nM in an assay for the detection of released CoA.GSK2194069 inhibits the proliferation of FAS in cancer cells through the action of acetoacetyl-coenzyme A and NADPH.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $149 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "GSK2194069"
Metronidazole
Cited
Metronidazol, Flagyl, Anagiardil
T1079443-48-1
Metronidazole (Metronidazol) is a synthetic nitroimidazole derivative with antiprotozoal and antibacterial activities.
- $30
Size
QTY
CitedApocynin Cited
NSC 2146, Acetovanillone, Acetoguaiacone
T6391498-02-2
Apocynin (NSC 2146) is a specific NADPH-oxidase inhibitor (IC50: 10 μM).
- $50
Size
QTY
CitedOrlistat Cited
Tetrahydrolipstatin, Ro-18-0647
T068696829-58-2
Orlistat (Tetrahydrolipstatin) is a lipase inhibitor and a fatty acid synthase (FASN) inhibitor. Orlistat has been shown to promote weight loss.
- $52
Size
QTY
CitedL-Carnitine
Levocarnitine, L(-)-Carnitine
T0846541-15-1
L-Carnitine (L(-)-Carnitine) is an amino acid derivative. L-Carnitine facilitates long-chain fatty acid entry into mitochondria, delivering substrate for oxidation and subsequent energy production. Fatty acids are utilized as an energy substrate in all tissues except the brain.
- $30
Size
QTY
Resveratrol Cited
trans-Resveratrol, SRT 501
T1558501-36-0
Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities. Resveratrol has a wide range of targets including COX, SIRT, LOC, etc. Resveratrol induces autophagy and apoptosis.
- $36
Size
QTY
CitedNAD+ Cited
β-Nicotinamide Adenine Dinucleotide, β-NAD, β-DPN, DPN, Cozymase
T160953-84-9
NAD+ (β-Nicotinamide Adenine Dinucleotide) is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH).
- $41
Size
QTY
CitedPasiniazid
Pasiniazide, Paraniazide, Isonicotinic acid hydrazide p-aminosalicylate
T04412066-89-9
Pasiniazid (Paraniazide) is an anti-TB and anti-leprosy drug.
- $42
Size
QTY
Triclosan Cited
Irgasan, Cloxifenolum
T13143380-34-5
Triclosan (Irgasan) is an antibacterial and antifungal agent.
- $41
Size
QTY
Citedtrans-Chalcone
Cinnamophenone, Chalkone, Chalcone
T3322614-47-1
trans-Chalcone (Chalkone) is an aromatic ketone that forms the central core for a variety of important biological compounds, which are known collectively as chalcones.
- $30
Size
QTY
Pyrazinamide
Pyrazinoic acid amide, Pyrazinecarboxamide
T142698-96-4
Pyrazinamide (Pyrazinecarboxamide), an antimycobacterial, is utilized therapeutically as an antitubercular agent, which is a synthetic pyrazinoic acid amide derivative.
- $45
Size
QTY
A-769662 Cited
A 769662
T2468844499-71-4
A-769662 is an effective, reversible AMPK activator(EC50=0.8 μM).
- $33
Size
QTY
CitedAKR1C1-IN-1
T141514906-68-7
AKR1C1-IN-1 is a human 20α-hydroxysteroid dehydrogenase (AKR1C1) inhibitor (Ki: 4 nM for AKR1C1).
- $38
Size
QTY
Product Introduction
Bioactivity
Chemical Properties
| Description | GSK2194069 is an active β-keto reductase (KR)-specific inhibitor of fatty acid synthase (FASN) with an IC50 of 7.7 nM in an assay for the detection of released CoA.GSK2194069 inhibits the proliferation of FAS in cancer cells through the action of acetoacetyl-coenzyme A and NADPH. |
| Targets&IC50 | β-ketoyl reductase:7.7 nM, Phosphatidylcholine:15.5 ± 9 nM(EC50) |
| In vitro | GSK2194069 (100 nM; 24 h) suppresses fatty acid synthase (FAS) activity in cancer cell lines (KATO-III, MKN45, A549, SNU-1) while maintaining FAS protein production levels.[1] GSK2194069 (5 μM and 20 μM) demonstrates higher efficacy in FASN-positive LNCaP cells compared to FASN-negative PC3 cells, correlating with higher FASN expression in LNCaP cells.[2] GSK2194069 (50 μM; 24 h) inhibits the growth of LNCaP-LN3 human prostate cancer cells.[3] GSK2194069 (60.4 nM; 24 h) exhibits metabolomic alterations, including decreases in L-acetyl carnitine, stearoyl carnitine, vaccenyl carnitine, and palmitoyl-L-carnitine in LNCaP-LN3 cells.[3] |
| Molecular Weight | 428.48 |
| Formula | C25H24N4O3 |
| Cas No. | 1332331-08-4 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 90.0 mg/mL (210.0 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
| ||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy GSK2194069 | purchase GSK2194069 | GSK2194069 cost | order GSK2194069 | GSK2194069 chemical structure | GSK2194069 in vitro | GSK2194069 formula | GSK2194069 molecular weight
- TOP
Feedback
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.