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FGFR-IN-11
Catalog No. T79257Cas No. 2658488-68-5
FGFR-IN-11 (compound I-5) is an orally active, covalent inhibitor of FGFR, with IC50 values of 9.9 nM (FGFR1), 3.1 nM (FGFR2), 16 nM (FGFR3), and 1.8 nM (FGFR4). This compound demonstrates nanomolar potency in inhibiting the proliferation of various cancer cells and significantly hinders tumor growth in xenograft mouse models [1].
FGFR-IN-11
Catalog No. T79257Cas No. 2658488-68-5
FGFR-IN-11 (compound I-5) is an orally active, covalent inhibitor of FGFR, with IC50 values of 9.9 nM (FGFR1), 3.1 nM (FGFR2), 16 nM (FGFR3), and 1.8 nM (FGFR4). This compound demonstrates nanomolar potency in inhibiting the proliferation of various cancer cells and significantly hinders tumor growth in xenograft mouse models [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,820 | 8-10 weeks | |
| 50 mg | $2,380 | 8-10 weeks | |
| 100 mg | $3,100 | 8-10 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | FGFR-IN-11 (compound I-5) is an orally active, covalent inhibitor of FGFR, with IC50 values of 9.9 nM (FGFR1), 3.1 nM (FGFR2), 16 nM (FGFR3), and 1.8 nM (FGFR4). This compound demonstrates nanomolar potency in inhibiting the proliferation of various cancer cells and significantly hinders tumor growth in xenograft mouse models [1]. |
| Targets&IC50 | FGFR1:9.9 nM, FGFR3:16 nM, FGFR4:1.8 nM, FGFR2:3.1 nM |
| In vitro | FGFR-IN-11, at concentrations ranging from 0.3 nM to 20 μM over a 72-hour period, effectively inhibits the growth of various cancer cell lines [1]. |
| In vivo | FGFR-IN-11, administered orally at a dose of 60 mg/kg daily for 21 days, significantly inhibited tumor growth in female nude mouse xenograft models of Huh-7 or NCI-H1581 without affecting the mouse body weight. [1] |
| Molecular Weight | 521.01 |
| Formula | C28H29ClN4O4 |
| Cas No. | 2658488-68-5 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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