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Pemigatinib

🥰Excellent
Catalog No. T12401Cas No. 1513857-77-6
Alias INCB054828

Pemigatinib (INCB054828) is an orally active, selective inhibitor of FGFR, with IC50 values of 0.4 nM for FGFR1, 0.5 nM for FGFR2, 1.2 nM for FGFR3, and 30 nM for FGFR4.

Pemigatinib

Pemigatinib

🥰Excellent
Purity: 99.95%
Catalog No. T12401Alias INCB054828Cas No. 1513857-77-6
Pemigatinib (INCB054828) is an orally active, selective inhibitor of FGFR, with IC50 values of 0.4 nM for FGFR1, 0.5 nM for FGFR2, 1.2 nM for FGFR3, and 30 nM for FGFR4.
Pack SizePriceAvailabilityQuantity
1 mg38 â‚¬In Stock
5 mg92 â‚¬In Stock
10 mg147 â‚¬In Stock
25 mg273 â‚¬In Stock
50 mg427 â‚¬In Stock
100 mg568 â‚¬In Stock
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Purity:99.95%
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Product Introduction

Bioactivity
Description
Pemigatinib (INCB054828) is an orally active, selective inhibitor of FGFR, with IC50 values of 0.4 nM for FGFR1, 0.5 nM for FGFR2, 1.2 nM for FGFR3, and 30 nM for FGFR4.
Targets&IC50
FGFR2:0.5 nM, FGFR1:0.4 nM, FGFR3:1.2 nM, FGFR4:30 nM
In vitro
In cells expressing FGFR2-CLIP1 fusion are sensitive to Pemigatinib (INCB054828; IC50 value of 10.16 nM)[3].
AliasINCB054828
Chemical Properties
Molecular Weight487.5
FormulaC24H27F2N5O4
Cas No.1513857-77-6
SmilesCCN1C(=O)N(Cc2c[nH]c3nc(CN4CCOCC4)cc3c12)c1c(F)c(OC)cc(OC)c1F
Relative Density.1.44 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 4.88 mg/mL (10 mM), Sonication is recommended.
10% DMSO+90% Saline: 0.1 mg/mL (0.21 mM), In vivo: Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately.

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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