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Pemigatinib (INCB054828) is an orally active, selective inhibitor of FGFR, with IC50 values of 0.4 nM for FGFR1, 0.5 nM for FGFR2, 1.2 nM for FGFR3, and 30 nM for FGFR4.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | 38 € | In Stock | |
5 mg | 92 € | In Stock | |
10 mg | 147 € | In Stock | |
25 mg | 273 € | In Stock | |
50 mg | 427 € | In Stock | |
100 mg | 568 € | In Stock |
Description | Pemigatinib (INCB054828) is an orally active, selective inhibitor of FGFR, with IC50 values of 0.4 nM for FGFR1, 0.5 nM for FGFR2, 1.2 nM for FGFR3, and 30 nM for FGFR4. |
Targets&IC50 | FGFR2:0.5 nM, FGFR1:0.4 nM, FGFR3:1.2 nM, FGFR4:30 nM |
In vitro | In cells expressing FGFR2-CLIP1 fusion are sensitive to Pemigatinib (INCB054828; IC50 value of 10.16 nM)[3]. |
Alias | INCB054828 |
Molecular Weight | 487.5 |
Formula | C24H27F2N5O4 |
Cas No. | 1513857-77-6 |
Smiles | CCN1C(=O)N(Cc2c[nH]c3nc(CN4CCOCC4)cc3c12)c1c(F)c(OC)cc(OC)c1F |
Relative Density. | 1.44 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO: 4.88 mg/mL (10 mM), Sonication is recommended. 10% DMSO+90% Saline: 0.1 mg/mL (0.21 mM), In vivo: Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. |
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