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Ezatiostat hydrochloride
Catalog No. T22776Cas No. 286942-97-0
Alias TLK199 HCl, TER199
Ezatiostat hydrochloride (TLK199 HCl) is an effective inhibitor of glutathione S-transferase. Ezatiostat hydrochloride is a novel glutathione analog and the potential treatment of cytopenias. In addition, Ezatiostat hydrochloride has been revealed to selectively bind to and thus inhibit GSTP1-1.
Ezatiostat hydrochloride
Catalog No. T22776Alias TLK199 HCl, TER199Cas No. 286942-97-0
Ezatiostat hydrochloride (TLK199 HCl) is an effective inhibitor of glutathione S-transferase. Ezatiostat hydrochloride is a novel glutathione analog and the potential treatment of cytopenias. In addition, Ezatiostat hydrochloride has been revealed to selectively bind to and thus inhibit GSTP1-1.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $53 | Backorder | |
| 5 mg | $75 | Backorder | |
| 10 mg | $123 | Backorder | |
| 25 mg | $211 | Backorder | |
| 50 mg | $323 | Backorder | |
| 100 mg | $545 | Backorder | |
| 200 mg | $817 | Backorder | |
| 500 mg | $1,227 | Backorder | |
| 1 mL x 10 mM (in DMSO) | $121 | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Ezatiostat hydrochloride (TLK199 HCl) is an effective inhibitor of glutathione S-transferase. Ezatiostat hydrochloride is a novel glutathione analog and the potential treatment of cytopenias. In addition, Ezatiostat hydrochloride has been revealed to selectively bind to and thus inhibit GSTP1-1. |
| In vitro | Because GST P1-1 can bind to and inhibit JNK, Ezatiostat hydrochloride has also been exhibited to inhibit GST P1-1, activate JNK, and promote the growth and maturation of hematopoietic progenitors in preclinical models. Moreover, Ezatiostat hydrochloride has been reported to stimulate the proliferation of myeloid precursors. Ezatiostat hydrochloride has been elucidated to induce growth inhibition and cellular apoptosis in human leukemia cells (CC50: 6-17μM). Apart from these, Ezatiostat hydrochloride has shown the stimulation of multilineage differentiation in mature monocytes, granulocytes, and erythrocytes [1][2]. |
| In vivo | Administration of Ezatiostat stimulates both lymphocyte production and bone marrow progenitor proliferation only in glutathione S-transferase P1-1 (GSTP1+/+) and not in GSTP1-/- animals[2]. |
| Alias | TLK199 HCl, TER199 |
| Molecular Weight | 566.11 |
| Formula | C27H36ClN3O6S |
| Cas No. | 286942-97-0 |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 28.3 mg/mL (50.00 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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