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ML-210
ML-210 (CID 49766530) is a glutathione peroxidase 4 (GPX4) inhibitor (EC50=30 nM) that is covalent and selective. ML-210 has antitumor activity and induces ferroptosis.
Catalog No. T8375Cas No. 1360705-96-9
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Purity:97%
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ML-210
Catalog No. T8375Alias CID 49766530Cas No. 1360705-96-9
ML-210 (CID 49766530) is a glutathione peroxidase 4 (GPX4) inhibitor (EC50=30 nM) that is covalent and selective. ML-210 has antitumor activity and induces ferroptosis.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $34 | In Stock | |
| 2 mg | $48 | In Stock | |
| 5 mg | $79 | In Stock | |
| 10 mg | $143 | In Stock | |
| 25 mg | $259 | In Stock | |
| 50 mg | $437 | In Stock | |
| 100 mg | $629 | In Stock | |
| 200 mg | $892 | In Stock | |
| 500 mg | $1,320 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $83 | In Stock |
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CitedProduct Introduction
Bioactivity
Chemical Properties
| Description | ML-210 (CID 49766530) is a glutathione peroxidase 4 (GPX4) inhibitor (EC50=30 nM) that is covalent and selective. ML-210 has antitumor activity and induces ferroptosis. |
| Targets&IC50 | GPX4:30 nM(EC50) |
| In vitro | METHODS: Human lung adenocarcinoma cell line HCC4006 was treated with ML-210 (10 µM) for 1 h. CETSA profiles were detected by Western Blot. RESULTS: ML-210 affects the thermal stability of GPX4, consistent with the binding to the cellular target. [1] METHODS: DRD cell lines were treated with ML-210 for 48 h, and cell viability was measured. RESULTS: ML-210 has an IC50 of 107 nM in the DRD cell line. [2] |
| Alias | CID 49766530 |
| Molecular Weight | 475.32 |
| Formula | C22H20Cl2N4O4 |
| Cas No. | 1360705-96-9 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 11 mg/mL (23.14 mM)  10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1.1 mg/mL (2.31 mM), Suspension. Working solution is recommended to be prepared and used immediately. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
10% DMSO+40% PEG300+5% Tween 80+45% Saline/DMSO
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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