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Cat No. | Product Name | Synonyms | Targets |
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T11709 | JAK3 covalent inhibitor-1 | JAK | |
JAK3 covalent inhibitor-1 is a potent and selective janus kinase 3 (JAK3) covalent inhibitor with an IC50 of 11 nM and shows 246-fold selectivity vs other JAKs. | |||
T41277 | PACMA 31 | Others | |
PACMA 31 is an irreversible and covalent inhibitor of protein disulfide isomerase (PDI) with an IC50 of 10 μM. PACMA 31 significantly suppresses ovarian tumor growth and exhibits tumor targeting ability. | |||
T16143 | MRTX-1257 | Ras | |
MRTX-1257 is a selective, irreversible, and covalent inhibitor of KRAS G12C. It has an IC50 of 900 pM for KRAS dependent ERK phosphorylation in H358 cells. MRTX1257 demonstrated 31% bioavailability in the mouse, with fre... | |||
T3583 | Macozinone | PBTZ169 | Antibacterial , DprE1 |
Macozinone (PBTZ169) inhibits decaprenylphosphoryl-β-d-ribose 2′-oxidase (DprE1), more efficiently than BTZ043. | |||
T7414 | ARS-853 | Apoptosis , Raf , Ras | |
ARS-853 is an inhibitor of K-RASG12C(IC50 : 2.5 μM), a mutant form of K-RAS that accumulates in the active GTP-bound state in certain cancer cells | |||
T9061 | EN4 | EN4 MYC inhibitor | c-Myc |
EN4 (EN4 MYC inhibitor) MYC inhibitor is a covalent ligand that targets cysteine 171 (C171) of MYC. It is selective for c-MYC over N-MYC and L-MYC, and inhibits MYC transcriptional activity, downregulates MYC targets, an... | |||
T8371 | ML188 | Virus Protease , SARS-CoV | |
ML188 is a selective noncovalent SARS-CoV 3CLpro inhibitor(IC50 : 1.5 μM), with moderate MW and good enzyme and antiviral inhibitory activity. | |||
T8684 | Sotorasib | AMG-510 | Ras |
Sotorasib (AMG-510) is an orally active and selective covalent inhibitor of KRAS G12C. Sotorasib binds to the GDP state of the inactive conformation of KRAS G12C and inhibits KRAS and its downstream signaling. Sotorasib ... | |||
T22461 | YKL-5-124 | CDK | |
YKL-5-124, a potent, selective and covalent CDK7 inhibitor with an IC50 of 9.7 nM, 1300 nM and 3020 nM for CDK7/Mat1/CycH, CDK2 and CDK9 respectively, displays biochemical and cellular selectivity for CDK7 over CDK12/13... | |||
T8375 | ML-210 | CID 49766530 | Ferroptosis , GPX , Glutathione Peroxidase , Ras |
ML-210 (CID 49766530) is a selective RAS and covalent glutathione peroxidase 4 (GPX4) inhibitor(GPX4, EC50 : 30 nM), with anti-cancer activity | |||
T8926 | Salcaprozate sodium | SNAC | Others |
Salcaprozate sodium (SNAC) is an oral absorption promoter, and has the potential as a delivery agent for oral forms of heparin and insulin. It could increase passive transcellular permeation across small intestinal epith... | |||
T8369 | Adagrasib | MRTX849 | Ras |
Adagrasib (MRTX849) is a potent, selective and covalent KRASG12C inhibitor with potential antineoplastic activity. It selectively modifies mutant cysteine 12 in GDP-bound KRASG12C, and inhibits KRAS-dependent signaling. | |||
T10460 | Batabulin | T138067 | Apoptosis , Microtubule Associated |
Batabulin (T138067) is an antitumor compound, which binds covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization. Batabulin affects cell morphology and leads to ce... | |||
T8421 | TED-347 | YAP | |
TED-347 is an irreversible and covalent inhibitor of TEAD4-Yap1 protein-protein interaction(EC50 of 5.9 μM), and inhibits glioblastoma cell viability. | |||
T10898 | Samuraciclib hydrochloride | ICEC0942 hydrochloride,CT7001 hydrochloride | Apoptosis , CDK |
Samuraciclib hydrochloride (ICEC0942 hydrochloride) is a potent, selective, ATP competitive and oral active CDK7 inhibitor with IC50 of 41 nM. The selectivity of Samuraciclib hydrochloride is 45-, 15-, 230- and 30-fold h... | |||
T79659 | SARS-CoV-2 3CLpro-IN-16 | SARS-CoV | |
SARS-CoV-2 3CLpro-IN-16 is a covalent SARS-CoV-2 3CLpro inhibitor that inhibits 3CLpro activity and achieves its inhibitory effect by forming a covalent bond with Cys145. | |||
T2256 | CNX-1351 | PI3K | |
CNX-1351 is a potent and isoform-selective targeted covalent PI3Kα inhibitor. | |||
T5154 | C-176 | C176,STING inhibitor 1 | STING |
C-176 (STING inhibitor 1) is a strong, covalent mouse STING inhibitor | |||
T11724 | JNJ-42226314 | Others | |
JNJ-42226314 is a competitive, highly selective, and reversible non-covalent monoacylglycerol lipase (MAGL) inhibitor. It exhibits dose-dependent enhancement of the major endocannabinoid 2-arachidonoylglycerol (2-AG) and... | |||
T7609 | ARS-1620 | Ras | |
ARS-1620 is a covalent inhibitor of K-RASG12C. | |||
T16515 | PF 750 | PF-750,UNII-7756CPP14K,ZINC27647189 | FAAH |
PF 750 (ZINC27647189) is a selective and covalent inhibitor of FAAH. PF 750 shows IC50s varying from 16.2 to 595 nM in different incubation times. | |||
T3664 | THZ1 | CDK7 inhibitor,THZ1 2HCl | CDK |
THZ1 (CDK7 inhibitor) is a novel selective and potent covalent CDK7 inhibitor. | |||
T4293 | THZ531 | CDK | |
THZ531 is a covalent inhibitor of both CDK12(IC50=158 nM) and CDK13(IC50=69 nM). | |||
T17029 | Tegobuvir | GS-9190,GS 333126 | HCV Protease |
Tegobuvir (GS 333126) is a specific and covalent HCV NS5B polymerase inhibitor. | |||
T60096 | EN106 | ZINC3888023 | Others |
EN106 is a potent inhibitor of FEMIB and is a cysteine-reactive covalent ligand. EN106 disrupts recognition of the key reductive stress substrate of FEM1B, FNIP1. | |||
T4736 | Cruzain-IN-1 | ML092 | Antibiotic |
Cruzain-IN-1 (ML092) is a covalent and reversible Cruzain inhibitor (IC50: 10 nM). | |||
T67933 | BAY-4931 | PPAR | |
BAY-4931 is a potent, covalent and selective PPARγ inverse-agonist with an IC 50 of 0.17 nM . | |||
T15793 | Lurbinectedin | PM01183 | Others |
Lurbinectedin (PM01183) is a DNA minor groove covalent binder. Lurbinectedin also shows effective anti-tumor activity. | |||
T11469 | GSK-3484862 | DNA Methyltransferase | |
GSK-3484862 is a non-covalent Dnmt1 inhibitor. It induces DNA hypomethylation to against cancer. | |||
T27319 | FIIN-4 | FIIN4 | FGFR |
FIIN-4 is a covalent inhibitor of FGFR and can be used in studies about metastatic breast cancer. | |||
T22306 | DGY-06-116 | FGFR , Src | |
DGY-06-116 is an selective and irreversible covalent inhibitor of Src and FGFR1 with IC50 value of 3nM and 8340 nM, respectively. | |||
T15351 | FT827 | DUB | |
FT827 is a covalent inhibitor of selective ubiquitin-specific protease 7 (USP7) (Ki=4.2 µM, Kd=7.8 µM) targeting the catalytic center of the autoinhibitory apolipoprotein form of USP7 for cancer research. | |||
T9303 | MRTX1133 | Ras | |
MRTX1133 is a KRAS G12D inhibitor (KD=0.2 pM) that is potent, selective, and non-covalent. MRTX1133 exhibits inhibitory activity against KRAS G12D-mutated tumors, but not against KRAS wild-type tumors. | |||
T8427 | Borussertib | Akt | |
Borussertib is a covalent-allosteric and first-in-class inhibitor of protein kinase Akt(IC50 of 0.8 nM and a Ki of 2.2 nM for Aktwt) | |||
T12542 | Rilzabrutinib | PRN1008 | EGFR , Others , HER , BTK |
Rilzabrutinib (PRN1008) is a reversible covalent, selective and oral active inhibitor of Bruton’s Tyrosine Kinase (BTK)(IC50 of 1.3 nM). | |||
T12236 | NMS-859 | ZINC169324353 | Others |
NMS-859 is an effective and covalent inhibitor of valosin-containing protein (VCP)/p97 with IC50s of 0.37 μM and 0.36 μM for wild-type VCP in the presence of 60 μM and 1 mM ATP in cells, respectively. | |||
T17389 | AMAS | Others | |
AMAS is a non-claevable heterobifunctional crosslinker with NHS ester and maleimide groups that enables covalent conjugation of amine- and sulfhydryl-containing molecules. | |||
T7329 | C-178 | STING | |
C-178 is a covalent inhibitor of STING, binds to Cys91 on STING to block its palmitoylation and prevents recruitment and phosphorylation of TBK1 in HEK293T cells. | |||
T8431 | JCN037 | EGFR | |
JCN037 is potent, non-covalent and brain-penetrant inhibitor of EGFR(EGFR, p-wtEGFR and pEGFRvⅢ with IC50 of 2.49 nM, 3.95 nM, 4.48 nM , respectively). | |||
T5407 | Branebrutinib | BMS986195 | BTK |
Branebrutinib (BMS986195) is a potent, covalent inhibitor of Bruton's tyrosine kinase (BTK), >5,000-fold selective over all kinases outside of the Tec family (IC50 <1 nM for BTK). | |||
T22372 | MYF-01-37 | 1-[3-Methyl-3-[3-(trifluoromethyl)anilino]pyrrolidin-1-yl]prop-2-en-1-one | Others , YAP |
MYF-01-37 (1-[3-Methyl-3-[3-(trifluoromethyl)anilino]pyrrolidin-1-yl]prop-2-en-1-one) is a novel covalent TEAD inhibitor. | |||
T10188 | 6RK73 | Others | |
6RK73 is a covalent irreversible and specific UCHL1 inhibitor (IC50: 0.23 µM). 6RK73 shows almost no inhibition of UCHL3 (IC50: 236 µM). | |||
T9203 | JH-X-119-01 | IRAK | |
JH-X-119-01 is a highly potent and selective covalent inhibitor of IRAK-1. | |||
T24827 | SR 16832 | SR-16832,SR16832 | PPAR |
SR 16832 is a dual-site PPARγ inhibitor. It also inhibits the binding of endogenous ligands and transcriptional activity of PPARγ, more effectively than the orthosteric covalent antagonist GW 9662 and T 0070907. | |||
T8569 | DMH-25 | mTOR | |
DMH25 is a novel covalent and potent inhibitor of mTOR and shows in vivo antitumor activity against triple-negative breast cancer cells. | |||
T5825 | Iadademstat dihydrochloride | ORY-1001(trans) | Histone Demethylase |
Iadademstat dihydrochloride (ORY-1001(trans)) , a Potent and Selective Covalent KDM1A/LSD1 Inhibitor, for the Treatment of Acute Leukemia. | |||
T5199 | COH000 | E1/E2/E3 Enzyme | |
COH000 is a covalent and irreversible inhibitor of small ubiquitin-like modifier (SUMO)-activating enzyme and inhibited SUMOylation (IC50: ~ 0.2 μM in vitro). | |||
T60050 | ANT3310 | Antibacterial | |
ANT3310 is an inhibitor of broad-spectrum covalent Serine β-Lactamase with IC50s ranging from 1 nM to 175 nM for AmpC, CTX-M-15, TEM-1, OXA-48, OXA-23, and KPC-2. ANT3310 can be used in studies about bacterial infection. | |||
T40292 | Opnurasib | NVP-JDQ443,JDQ-443,Opnurasib | Ras |
Opnurasib (JDQ-443) is an orally available and selective and potent covalent KRAS G12C inhibitor with antitumor activity for the study of advanced non-small cell lung cancer. | |||
T9028 | STING-IN-2 | C-170 | STING |
STING-IN-2 (C-170) is a potent and covalent inhibitor of STING. C-170 efficiently inhibits both mouse STING (mmSTING) and human STING (hsSTING). It can be used for autoinflammatory disease research. |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T8307 | Hydroxy-α-sanshool | Hydroxy-α-sanshool | Endogenous Metabolite , TRP/TRPV Channel |
Hydroxy-α-sanshool is an alkyl amide isolated from the pepper. It acts as a TRPA1 covalent and TRPV1 non-covalent agonist (EC50s: 69 and 1.1 μM). | |||
TN1620 | Eriocalyxin B | Apoptosis , cAMP , NF-κB , STAT | |
Eriocalyxin B induces apoptosis and cell cycle arrest in pancreatic adenocarcinoma cells through caspase- and p53-dependent pathways, should be considered a candidate for pancreatic cancer treatment; it is a specific inh... | |||
T4889 | 2,6-Diaminoheptanedioic acid | Others , Endogenous Metabolite | |
Diaminopimelic acid or DAPA is a lysine-like amino acid derivative that is a key component of the bacterial cell wall. DAPA is incorporated or integrated into peptidoglycan of gram negative bacteria and is the attachment... | |||
T11555 | Heptasaccharide Glc4Xyl3 | Others | |
Heptasaccharide Glc4Xyl3 is a covalent inhibitor of endo-xyloglucanases. It used for the identification and analysis of diverse xyloglucan-active enzymes in nature. | |||
TN4840 | Psoromic acid | Others | |
Psoromic acid is a selective and covalent rab-prenylation inhibitor targeting autoinhibited RabGGTase, it shows antibacterial activities against Streptococcus gordonii and Porphyromonas gingivalis, and it is an effective... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-01007 | VEGFC Protein, Human, Recombinant (His) | Human | HEK293 |
Vascular endothelial growth factor C (VEGF-C) is a member of the VEGF family. Upon biosynthesis, VEGF-C protein is secreted as a non-covalent momodimer in an anti-parellel fashion. VEGF-C protein is a dimeric glycoprotei... | |||
TMPY-03156 | VEGFC Protein, Mouse/Rat, Recombinant (aa 108-223, His) | Mouse,Rat | HEK293 |
Vascular endothelial growth factor C (VEGF-C) is a member of the VEGF family. Upon biosynthesis, VEGF-C protein is secreted as a non-covalent momodimer in an anti-parellel fashion. VEGF-C protein is a dimeric glycoprotei... | |||
TMPY-02521 | HIST3H2A Protein, Human, Recombinant | Human | E. coli |
Histones are a complex family of highly conserved basic proteins responsible for packaging chromosomal DNA into nucleosomes. There are subtype diversities: H1, H2A, H2B, and H3 or H4. It has become more and more evident ... | |||
TMPY-01474 | PAI-1 Protein, Human, Recombinant (His) | Human | HEK293 |
Plasminogen activator inhibitor 1, also known as PAI-1, Endothelial plasminogen activator inhibitor, SerpinE1 and PLANH1, is a secreted glycoprotein that belongs to the serpin family. SerpinE1 is the primary physiologica... | |||
TMPH-03601 | Streptavidin Protein, S. avidinii, Recombinant (His) | Streptomyces avidinii | Yeast |
The biological function of streptavidin is not known. Forms a strong non-covalent specific complex with biotin (one molecule of biotin per subunit of streptavidin). | |||
TMPH-03264 | P53 Protein, Rat, Recombinant (His) | Rat | E. coli |
Involved in phycobilisome (PBS) degradation during nutrient deprivation. May mark the PBS for degradation by covalent association with PBS components or may disrupt the PBS via ionic interactions. | |||
TMPH-03253 | BCAN Protein, Rat, Recombinant (His & Myc) | Rat | Baculovirus |
The biological function of streptavidin is not known. Forms a strong non-covalent specific complex with biotin (one molecule of biotin per subunit of streptavidin). | |||
TMPJ-01278 | SENP8 Protein, Human, Recombinant (His) | Human | E. coli |
Sentrin-Specific Protease 8 (SENP8) mediates the reversible covalent modification of proteins by NEDD8. SENP8 catalyzes the full-length NEDD8 to generate its mature form and deconjugation of NEDD8 from targeted proteins ... | |||
TMPH-01149 | Human coronavirus HKU1 (isolate N1) Spike glycoprotein (His & Myc) | HCoV-HKU1 | E. coli |
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Me... | |||
TMPH-00402 | Classical swine fever virus Genome polyprotein (His) | CSFV | Baculovirus |
Diphtheria toxin, produced by a phage infecting Corynebacterium diphtheriae, is a proenzyme that, after activation, catalyzes the covalent attachment of the ADP ribose moiety of NAD to elongation factor 2. Fragment A is ... | |||
TMPJ-01221 | UBE2J2 Protein, Human, Recombinant (GST) | Human | E. coli |
Ubiquitin-Conjugating Enzyme E2 J2 (UBE2J2) belongs to the ubiquitin-conjugating enzyme family. UBE2J2 is involved in the ubiquitiantion. UBE2J2 located in the membrane of the endoplasmic reticulum, catalyzes the covalen... | |||
TMPY-02842 | UBE2L6 Protein, Human, Recombinant (His) | Human | E. coli |
UBCH8, also known as UBE2L6, belongs to the ubiquitin-conjugating enzyme family. The family of ubiquitin-conjugating (E2) enzymes is characterized by the presence of a highly conserved ubiquitin-conjugating (UBC) domain.... | |||
TMPY-02129 | Transglutaminase 3/TGM3 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
Transglutaminases (TGase) are a family of calcium-dependent acyl-transfer enzymes ubiquitously expressed in mammalian cells and responsible for catalyzing covalent cross-links between proteins or peptides. Transglutamina... | |||
TMPJ-01334 | UBE2Z Protein, Human, Recombinant (His) | Human | E. coli |
Ubiquitin-Conjugating Enzyme E2 Z (ZUBE2Z) is a member of the E2 ubiquitin-conjugating enzyme family. ZUBE2Z is widely expressed in many tissues, with high expression found in the placenta, pancreas, spleen, and testis. ... | |||
TMPJ-01198 | UBE2R2 Protein, Human, Recombinant (His) | Human | E. coli |
Ubiquitin-Conjugating Enzyme E2 R2 (UBE2R2) is a modification enzyme that belongs to the ubiquitin-conjugating enzyme family. UBE2R2 is involved in cell growth and transformation. It accepts ubiquitin from the E1 complex... | |||
TMPJ-00033 | UBE2B Protein, Human, Recombinant (His) | Human | Human Cells |
Ubiquitin-Conjugating Enzyme E2 B (UBE2B) is a member of the ubiquitin-conjugating enzyme family. UBE2B accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. It is shown that UBE2... | |||
TMPJ-01069 | Serpin A1e Protein, Mouse, Recombinant (His) | Mouse | Human Cells |
Alpha-1-antitrypsin 1-5(SERPIN A1) is a secreted protein and belongs to the serpin family. Serpins bind the protease active site resulting in a major conformational rearrangement that traps the enzyme in a covalent acyl-... | |||
TMPJ-00985 | UBE2A Protein, Human, Recombinant (GST, His) | Human | E. coli |
Ubiquitin-Conjugating Enzyme E2 (UBE2A) is a member of the E2 Ubiquitin-Conjugating Enzyme family. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived prot... | |||
TMPH-01148 | Human coronavirus HKU1 (isolate N1) Protein I (His) | HCoV-HKU1 | E. coli |
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Me... | |||
TMPJ-01362 | UBAP1 Protein, Human, Recombinant (His) | Human | E. coli |
Ubiquitin-Associated Protein 1 (UBAP1) belongs to the UBA domain family. Members of this family are related to ubiquitin and the ubiquitination pathway. Because of their cytogenetic location, this UBA domain family membe... | |||
TMPH-01702 | SMAD6 Protein, Human, Recombinant (E. coli, His & Myc) | Human | E. coli |
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a p... | |||
TMPJ-01403 | UBE2D4 Protein, Human, Recombinant (GST) | Human | E. coli |
Ubiquitin-Conjugating Enzyme E2 D4 (UBE2D4) is a ligase that belongs to the Ubiquitin-Conjugating Enzyme family. UBE2D4 has been proposed to participate in Ubl conjugation pathway. UBE2D4 takes part in post-translational... | |||
TMPH-03575 | Sortase A Protein, S. aureus, Recombinant (His) | Staphylococcus aureus | E. coli |
Transpeptidase that anchors surface proteins to the cell wall. Recognizes and modifies its substrate by proteolytic cleavage of a C-terminal sorting signal. Following cleavage, a covalent intermediate is formed via a thi... | |||
TMPH-03227 | Rabies virus (RABV) (strain PM1503/AVO1) Matrix Protein (His) | RABV | E. coli |
Transpeptidase that anchors surface proteins to the cell wall. Recognizes and modifies its substrate by proteolytic cleavage of a C-terminal sorting signal. Following cleavage, a covalent intermediate is formed via a thi... | |||
TMPH-00921 | IDUA Protein, Human, Recombinant (His) | Human | E. coli |
Metalloprotease that plays key roles in regulating the formation of the extracellular matrix (ECM) via processing of various precursor proteins into mature functional enzymes or structural proteins. Thereby participates ... | |||
TMPJ-01055 | HBA1 Protein, Human, Recombinant (His) | Human | E. coli |
Hemoglobin subunit alpha 1 (HBA1), also known as α2β2, is a hetero-tetramer consisting of two α and two β subunits held together by non-covalent interactions. Each subunit contains a heme group with an iron atom in the F... | |||
TMPY-03155 | VEGFC Protein, Mouse/Rat, Recombinant (aa 108-223, hFc) | Mouse,Rat | HEK293 |
Vascular endothelial growth factor C (VEGF-C) is a member of the VEGF family. Upon biosynthesis, VEGF-C protein is secreted as a non-covalent momodimer in an anti-parellel fashion. VEGF-C protein is a dimeric glycoprotei... | |||
TMPY-00933 | TIMP-2 Protein, Human, Recombinant (hFc) | Human | HEK293 |
Tissue inhibitors of metalloproteinases (TIMP) family are natural inhibitors of the matrix metalloproteinases (MMPs), the zinc enzymes involved in extracellular matrix maintenance and remodeling. The TIMP family encompas... | |||
TMPH-03304 | GRIN1 Protein, Rat, Recombinant (His) | Rat | E. coli |
Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via tran... | |||
TMPY-03700 | S100A11 Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Protein S100-A11, also known as S100 calcium-binding protein A11, S100A11 and MLN70, is a member of theS-100 family. S100A11 is widely expressed in multiple tissues, and is located in cytoplasm, nucleus, and even cell pe... | |||
TMPY-01868 | TIMP-2 Protein, Human, Recombinant | Human | HEK293 |
Tissue inhibitors of metalloproteinases (TIMP) family are natural inhibitors of the matrix metalloproteinases (MMPs), the zinc enzymes involved in extracellular matrix maintenance and remodeling. The TIMP family encompas... | |||
TMPY-03052 | MFAP5 Protein, Human, Recombinant (His) | Human | HEK293 |
MFAP5 (Microfibril Associated Protein 5, also known as MAGP2) is a Protein Coding gene. MFAP5 is a component of the elastin-associated microfibrils. It belongs to the MFAP family. As a 25-kD microfibril-associated glycop... | |||
TMPY-00323 | Hepatitis C virus (HCV-1a) NS3 protease/helicase immunodominant region Protein (aa 1356-1459, GST) | HCV | E. coli |
HCV NS3 displays three enzymatic activities: serine protease, NTPase, and RNA helicase. HCV NS3 serine protease, in association with NS4A, is responsible for the cleavages of NS3-NS4A, NS4A-NS4B, NS4B-NS5A, and NS5A-NS5B... | |||
TMPY-01331 | S100A11 Protein, Human, Recombinant | Human | E. coli |
Protein S100-A11, also known as S100 calcium-binding protein A11, S100A11 and MLN70, is a member of theS-100 family. S100A11 is widely expressed in multiple tissues, and is located in cytoplasm, nucleus, and even cell pe... | |||
TMPJ-01089 | TFF1 Protein, Mouse, Recombinant (His) | Mouse | Human Cells |
Trefoil Factor 1 (TFF1) belongs to the three structurally related secreted proteins that contain trefoil domains.TFF1 is an approximately peptide that has an important effect in epithelial regeneration and wound healing... | |||
TMPJ-00486 | SUMO2 Protein, Human, Recombinant (His) | Human | E. coli |
Small Ubiquitin-Related Modifier 2 (SUMO2) is an Ubiquitin-like protein that belongs to the ubiquitin family with SUMO subfamily. It is a family of small, related proteins that can be enzymatically attached to a target p... | |||
TMPY-02642 | UBE2W Protein, Human, Recombinant (His) | Human | E. coli |
Ubiquitin-conjugating enzymes, also known as UBE2W, E2 enzymes and more rarely as ubiquitin-carrier enzymes, perform the second step of protein ubiquitination. The modification of protein with ubiquitin is an important c... | |||
TMPH-03056 | Vacuolar protease A Protein, Neosartorya fumigata, Recombinant (His) | Neosartorya fumigata | E. coli |
Receptor-activated non-selective cation channel involved in pain detection and possibly also in cold perception, oxygen concentration perception, cough, itch, and inner ear function. Shows 8-fold preference for divalent ... | |||
TMPH-01127 | COMMD5 Protein, Human, Recombinant (His) | Human | E. coli |
Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via tran... | |||
TMPY-02348 | ISG15 Protein, Human, Recombinant | Human | E. coli |
Interferon-induced 17 kDa protein (ISG15), a 15-kDa protein of unique primary amino acid sequence, functions intracellularly as a ubiquitin homolog and a cytokine that induces production of IFN-gamma and augments NK / ly... | |||
TMPY-02467 | ISG15 Protein, Human, Recombinant (mature form) | Human | E. coli |
Interferon-induced 17 kDa protein (ISG15), a 15-kDa protein of unique primary amino acid sequence, functions intracellularly as a ubiquitin homolog and a cytokine that induces production of IFN-gamma and augments NK / ly... | |||
TMPH-02703 | HEBP1 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
Enoyl-ACP reductase of the type II fatty acid syntase (FAS-II) system, which is involved in the biosynthesis of mycolic acids, a major component of mycobacterial cell walls. Catalyzes the NADH-dependent reduction of the ... | |||
TMPJ-01100 | UBE2V1 Protein, Human, Recombinant (His) | Human | E. coli |
Ubiquitin-Conjugating Enzyme Variant 1a (UBE2V1) is a member of the Ubiquitin-conjugating (E2) enzyme family. The E2 catalytic core domain of UBE2V1 lacks an active site cysteine residue, rendering it catalytically inact... | |||
TMPH-00595 | HtpG Protein, E. coli, Recombinant | E. coli | E. coli |
An outer membrane lipoprotein that controls the distance between the inner and outer membranes; adding residues to Lpp increases the width of the periplasm. The only protein known to be covalently linked to the peptidogl... | |||
TMPH-01153 | Human coronavirus OC43 Nucleoprotein/NP Protein (His & Myc) | HCoV-OC43 | HEK293 |
E3 ubiquitin ligase required to protect genome stability in response to replication stress. Acts as a key regulator of interstrand cross-link repair, which takes place when both strands of duplex DNA are covalently tethe... | |||
TMPY-00629 | PAI-1 Protein, Rat, Recombinant (hFc) | Rat | HEK293 |
Plasminogen activator inhibitor 1, also known as PAI-1, Endothelial plasminogen activator inhibitor, SerpinE1 and PLANH1, is a secreted glycoprotein that belongs to the serpin family. SerpinE1 is the primary physiologica... | |||
TMPY-02559 | PAI-1 Protein, Rat, Recombinant (His) | Rat | HEK293 |
Plasminogen activator inhibitor 1, also known as PAI-1, Endothelial plasminogen activator inhibitor, SerpinE1 and PLANH1, is a secreted glycoprotein that belongs to the serpin family. SerpinE1 is the primary physiologica... | |||
TMPH-02053 | RBM14 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11)... | |||
TMPH-00639 | Hygromycin-B 4-O-kinase Protein, E. coli, Recombinant (His) | E. coli | E. coli |
With TolR probably plays a role in maintaining the position of the peptidoglycan cell wall in the periplasm (Probable). Plays a role in resistance to environmental stress, and a role in outer membrane functionality and c... | |||
TMPH-02366 | Junin mammarenavirus (JUNV) Nucleoprotein/NP Protein (His & SUMO) | JUNV | E. coli |
Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Substrates include SYT11 and VDAC1. Other substrates are BCL2, CCNE1, GPR37, ... | |||
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Cat No. | Product Name | ||
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L9411 | Cysteine Covalent Library | 72 compounds | |
The cysteine covalent library contains 72 compounds. | |||
L9410 | Covalent Inhibitor Library | 1949 compounds | |
A unique collection of 1949 covalent Inhibitors and other molecules with common warheads like chloroacetyl,2-Chloropropionyl,Acryloyl,sulfonyl fluoride, alkyne,acrylamide, ketocarbonyl,disulfide bond, etc. | |||
L6150 | Covalent Natural Product Library | 596 compounds | |
Detialed biological information and pharmacological information of the products, providing theoretical direction and research basis for screening. | |||
DO2200 | Covalent inhibitors Library | 12000 compounds | |
L7860 | Mini Electrophilic Heterocyclic Fragment Library | 369 compounds | |
369 compounds in total in the Highly Solubility Covalent Heterocyclic Fragment Library | |||
L3500 | Histone Modification Compound Library | 480 compounds | |
A unique collection of 480 histone modification related compounds for high throughput screening (HTS) and high content screening (HCS); | |||
L8600 | Ubiquitination Compound Library | 214 compounds | |
A unique collection of 214 ubiquitination related small chemicals can be used for high throughput and high content screening; | |||
L8300 | Chromatin Modification Compound Library | 256 compounds | |
A unique collection of 256 compounds targeting chromatin remodeling pathway for high throughput screening (HTS) and high content screening (HCS); |