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Search Results for " covalent "

Targets

314

Compounds

5

Natural Products

51

Recombinant Proteins

8

Libraries

Cat No. Product Name Synonyms Targets
T11709 JAK3 covalent inhibitor-1 JAK
JAK3 covalent inhibitor-1 is a potent and selective janus kinase 3 (JAK3) covalent inhibitor with an IC50 of 11 nM and shows 246-fold selectivity vs other JAKs.
T41277 PACMA 31 Others
PACMA 31 is an irreversible and covalent inhibitor of protein disulfide isomerase (PDI) with an IC50 of 10 μM. PACMA 31 significantly suppresses ovarian tumor growth and exhibits tumor targeting ability.
T16143 MRTX-1257 Ras
MRTX-1257 is a selective, irreversible, and covalent inhibitor of KRAS G12C. It has an IC50 of 900 pM for KRAS dependent ERK phosphorylation in H358 cells. MRTX1257 demonstrated 31% bioavailability in the mouse, with fre...
T3583 Macozinone PBTZ169 Antibacterial , DprE1
Macozinone (PBTZ169) inhibits decaprenylphosphoryl-β-d-ribose 2′-oxidase (DprE1), more efficiently than BTZ043.
T7414 ARS-853 Apoptosis , Raf , Ras
ARS-853 is an inhibitor of K-RASG12C(IC50 : 2.5 μM), a mutant form of K-RAS that accumulates in the active GTP-bound state in certain cancer cells
T9061 EN4 EN4 MYC inhibitor c-Myc
EN4 (EN4 MYC inhibitor) MYC inhibitor is a covalent ligand that targets cysteine 171 (C171) of MYC. It is selective for c-MYC over N-MYC and L-MYC, and inhibits MYC transcriptional activity, downregulates MYC targets, an...
T8371 ML188 Virus Protease , SARS-CoV
ML188 is a selective noncovalent SARS-CoV 3CLpro inhibitor(IC50 : 1.5 μM), with moderate MW and good enzyme and antiviral inhibitory activity.
T8684 Sotorasib AMG-510 Ras
Sotorasib (AMG-510) is an orally active and selective covalent inhibitor of KRAS G12C. Sotorasib binds to the GDP state of the inactive conformation of KRAS G12C and inhibits KRAS and its downstream signaling. Sotorasib ...
T22461 YKL-5-124 CDK
YKL-5-124, a potent, selective and covalent CDK7 inhibitor with an IC50 of 9.7 nM, 1300 nM and 3020 nM for CDK7/Mat1/CycH, CDK2 and CDK9 respectively, displays biochemical and cellular selectivity for CDK7 over CDK12/13...
T8375 ML-210 CID 49766530 Ferroptosis , GPX , Glutathione Peroxidase , Ras
ML-210 (CID 49766530) is a selective RAS and covalent glutathione peroxidase 4 (GPX4) inhibitor(GPX4, EC50 : 30 nM), with anti-cancer activity
T8926 Salcaprozate sodium SNAC Others
Salcaprozate sodium (SNAC) is an oral absorption promoter, and has the potential as a delivery agent for oral forms of heparin and insulin. It could increase passive transcellular permeation across small intestinal epith...
T8369 Adagrasib MRTX849 Ras
Adagrasib (MRTX849) is a potent, selective and covalent KRASG12C inhibitor with potential antineoplastic activity. It selectively modifies mutant cysteine 12 in GDP-bound KRASG12C, and inhibits KRAS-dependent signaling.
T10460 Batabulin T138067 Apoptosis , Microtubule Associated
Batabulin (T138067) is an antitumor compound, which binds covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization. Batabulin affects cell morphology and leads to ce...
T8421 TED-347 YAP
TED-347 is an irreversible and covalent inhibitor of TEAD4-Yap1 protein-protein interaction(EC50 of 5.9 μM), and inhibits glioblastoma cell viability.
T10898 Samuraciclib hydrochloride ICEC0942 hydrochloride,CT7001 hydrochloride Apoptosis , CDK
Samuraciclib hydrochloride (ICEC0942 hydrochloride) is a potent, selective, ATP competitive and oral active CDK7 inhibitor with IC50 of 41 nM. The selectivity of Samuraciclib hydrochloride is 45-, 15-, 230- and 30-fold h...
T79659 SARS-CoV-2 3CLpro-IN-16 SARS-CoV
SARS-CoV-2 3CLpro-IN-16 is a covalent SARS-CoV-2 3CLpro inhibitor that inhibits 3CLpro activity and achieves its inhibitory effect by forming a covalent bond with Cys145.
T2256 CNX-1351 PI3K
CNX-1351 is a potent and isoform-selective targeted covalent PI3Kα inhibitor.
T5154 C-176 C176,STING inhibitor 1 STING
C-176 (STING inhibitor 1) is a strong, covalent mouse STING inhibitor
T11724 JNJ-42226314 Others
JNJ-42226314 is a competitive, highly selective, and reversible non-covalent monoacylglycerol lipase (MAGL) inhibitor. It exhibits dose-dependent enhancement of the major endocannabinoid 2-arachidonoylglycerol (2-AG) and...
T7609 ARS-1620 Ras
ARS-1620 is a covalent inhibitor of K-RASG12C.
T16515 PF 750 PF-750,UNII-7756CPP14K,ZINC27647189 FAAH
PF 750 (ZINC27647189) is a selective and covalent inhibitor of FAAH. PF 750 shows IC50s varying from 16.2 to 595 nM in different incubation times.
T3664 THZ1 CDK7 inhibitor,THZ1 2HCl CDK
THZ1 (CDK7 inhibitor) is a novel selective and potent covalent CDK7 inhibitor.
T4293 THZ531 CDK
THZ531 is a covalent inhibitor of both CDK12(IC50=158 nM) and CDK13(IC50=69 nM).
T17029 Tegobuvir GS-9190,GS 333126 HCV Protease
Tegobuvir (GS 333126) is a specific and covalent HCV NS5B polymerase inhibitor.
T60096 EN106 ZINC3888023 Others
EN106 is a potent inhibitor of FEMIB and is a cysteine-reactive covalent ligand. EN106 disrupts recognition of the key reductive stress substrate of FEM1B, FNIP1.
T4736 Cruzain-IN-1 ML092 Antibiotic
Cruzain-IN-1 (ML092) is a covalent and reversible Cruzain inhibitor (IC50: 10 nM).
T67933 BAY-4931 PPAR
BAY-4931 is a potent, covalent and selective PPARγ inverse-agonist with an IC 50 of 0.17 nM .
T15793 Lurbinectedin PM01183 Others
Lurbinectedin (PM01183) is a DNA minor groove covalent binder. Lurbinectedin also shows effective anti-tumor activity.
T11469 GSK-3484862 DNA Methyltransferase
GSK-3484862 is a non-covalent Dnmt1 inhibitor. It induces DNA hypomethylation to against cancer.
T27319 FIIN-4 FIIN4 FGFR
FIIN-4 is a covalent inhibitor of FGFR and can be used in studies about metastatic breast cancer.
T22306 DGY-06-116 FGFR , Src
DGY-06-116 is an selective and irreversible covalent inhibitor of Src and FGFR1 with IC50 value of 3nM and 8340 nM, respectively.
T15351 FT827 DUB
FT827 is a covalent inhibitor of selective ubiquitin-specific protease 7 (USP7) (Ki=4.2 µM, Kd=7.8 µM) targeting the catalytic center of the autoinhibitory apolipoprotein form of USP7 for cancer research.
T9303 MRTX1133 Ras
MRTX1133 is a KRAS G12D inhibitor (KD=0.2 pM) that is potent, selective, and non-covalent. MRTX1133 exhibits inhibitory activity against KRAS G12D-mutated tumors, but not against KRAS wild-type tumors.
T8427 Borussertib Akt
Borussertib is a covalent-allosteric and first-in-class inhibitor of protein kinase Akt(IC50 of 0.8 nM and a Ki of 2.2 nM for Aktwt)
T12542 Rilzabrutinib PRN1008 EGFR , Others , HER , BTK
Rilzabrutinib (PRN1008) is a reversible covalent, selective and oral active inhibitor of Bruton’s Tyrosine Kinase (BTK)(IC50 of 1.3 nM).
T12236 NMS-859 ZINC169324353 Others
NMS-859 is an effective and covalent inhibitor of valosin-containing protein (VCP)/p97 with IC50s of 0.37 μM and 0.36 μM for wild-type VCP in the presence of 60 μM and 1 mM ATP in cells, respectively.
T17389 AMAS Others
AMAS is a non-claevable heterobifunctional crosslinker with NHS ester and maleimide groups that enables covalent conjugation of amine- and sulfhydryl-containing molecules.
T7329 C-178 STING
C-178 is a covalent inhibitor of STING, binds to Cys91 on STING to block its palmitoylation and prevents recruitment and phosphorylation of TBK1 in HEK293T cells.
T8431 JCN037 EGFR
JCN037 is potent, non-covalent and brain-penetrant inhibitor of EGFR(EGFR, p-wtEGFR and pEGFRvⅢ with IC50 of 2.49 nM, 3.95 nM, 4.48 nM , respectively).
T5407 Branebrutinib BMS986195 BTK
Branebrutinib (BMS986195) is a potent, covalent inhibitor of Bruton's tyrosine kinase (BTK), >5,000-fold selective over all kinases outside of the Tec family (IC50 <1 nM for BTK).
T22372 MYF-01-37 1-[3-Methyl-3-[3-(trifluoromethyl)anilino]pyrrolidin-1-yl]prop-2-en-1-one Others , YAP
MYF-01-37 (1-[3-Methyl-3-[3-(trifluoromethyl)anilino]pyrrolidin-1-yl]prop-2-en-1-one) is a novel covalent TEAD inhibitor.
T10188 6RK73 Others
6RK73 is a covalent irreversible and specific UCHL1 inhibitor (IC50: 0.23 µM). 6RK73 shows almost no inhibition of UCHL3 (IC50: 236 µM).
T9203 JH-X-119-01 IRAK
JH-X-119-01 is a highly potent and selective covalent inhibitor of IRAK-1.
T24827 SR 16832 SR-16832,SR16832 PPAR
SR 16832 is a dual-site PPARγ inhibitor. It also inhibits the binding of endogenous ligands and transcriptional activity of PPARγ, more effectively than the orthosteric covalent antagonist GW 9662 and T 0070907.
T8569 DMH-25 mTOR
DMH25 is a novel covalent and potent inhibitor of mTOR and shows in vivo antitumor activity against triple-negative breast cancer cells.
T5825 Iadademstat dihydrochloride ORY-1001(trans) Histone Demethylase
Iadademstat dihydrochloride (ORY-1001(trans)) , a Potent and Selective Covalent KDM1A/LSD1 Inhibitor, for the Treatment of Acute Leukemia.
T5199 COH000 E1/E2/E3 Enzyme
COH000 is a covalent and irreversible inhibitor of small ubiquitin-like modifier (SUMO)-activating enzyme and inhibited SUMOylation (IC50: ~ 0.2 μM in vitro).
T60050 ANT3310 Antibacterial
ANT3310 is an inhibitor of broad-spectrum covalent Serine β-Lactamase with IC50s ranging from 1 nM to 175 nM for AmpC, CTX-M-15, TEM-1, OXA-48, OXA-23, and KPC-2. ANT3310 can be used in studies about bacterial infection.
T40292 Opnurasib NVP-JDQ443,JDQ-443,Opnurasib Ras
Opnurasib (JDQ-443) is an orally available and selective and potent covalent KRAS G12C inhibitor with antitumor activity for the study of advanced non-small cell lung cancer.
T9028 STING-IN-2 C-170 STING
STING-IN-2 (C-170) is a potent and covalent inhibitor of STING. C-170 efficiently inhibits both mouse STING (mmSTING) and human STING (hsSTING). It can be used for autoinflammatory disease research.

Compounds

JAK3 covalent inhibitor-1
T11709
Synonym:
Target: JAK
PACMA 31
T41277
Synonym:
Target: Others
MRTX-1257
T16143
Synonym:
Target: Ras
Macozinone
T3583
Synonym: PBTZ169
Target: Antibacterial, DprE1
ARS-853
T7414
Synonym:
Target: Apoptosis, Raf, Ras
EN4
T9061
Synonym: EN4 MYC inhibitor
Target: c-Myc
ML188
T8371
Synonym:
Target: Virus Protease, SARS-CoV
Sotorasib
T8684
Synonym: AMG-510
Target: Ras
YKL-5-124
T22461
Synonym:
Target: CDK
ML-210
T8375
Synonym: CID 49766530
Target: Ferroptosis, GPX, Glutathione Peroxidase, Ras
Salcaprozate sodium
T8926
Synonym: SNAC
Target: Others
Adagrasib
T8369
Synonym: MRTX849
Target: Ras
Batabulin
T10460
Synonym: T138067
Target: Apoptosis, Microtubule Associated
TED-347
T8421
Synonym:
Target: YAP
Samuraciclib hydrochloride
T10898
Synonym: ICEC0942 hydrochloride,CT7001 hydrochloride
Target: Apoptosis, CDK
SARS-CoV-2 3CLpro-IN-16
T79659
Synonym:
Target: SARS-CoV
CNX-1351
T2256
Synonym:
Target: PI3K
C-176
T5154
Synonym: C176,STING inhibitor 1
Target: STING
JNJ-42226314
T11724
Synonym:
Target: Others
ARS-1620
T7609
Synonym:
Target: Ras
PF 750
T16515
Synonym: PF-750,UNII-7756CPP14K,ZINC27647189
Target: FAAH
THZ1
T3664
Synonym: CDK7 inhibitor,THZ1 2HCl
Target: CDK
THZ531
T4293
Synonym:
Target: CDK
Tegobuvir
T17029
Synonym: GS-9190,GS 333126
Target: HCV Protease
EN106
T60096
Synonym: ZINC3888023
Target: Others
Cruzain-IN-1
T4736
Synonym: ML092
Target: Antibiotic
BAY-4931
T67933
Synonym:
Target: PPAR
Lurbinectedin
T15793
Synonym: PM01183
Target: Others
GSK-3484862
T11469
Synonym:
Target: DNA Methyltransferase
FIIN-4
T27319
Synonym: FIIN4
Target: FGFR
DGY-06-116
T22306
Synonym:
Target: FGFR, Src
FT827
T15351
Synonym:
Target: DUB
MRTX1133
T9303
Synonym:
Target: Ras
Borussertib
T8427
Synonym:
Target: Akt
Rilzabrutinib
T12542
Synonym: PRN1008
Target: EGFR, Others, HER, BTK
NMS-859
T12236
Synonym: ZINC169324353
Target: Others
AMAS
T17389
Synonym:
Target: Others
C-178
T7329
Synonym:
Target: STING
JCN037
T8431
Synonym:
Target: EGFR
Branebrutinib
T5407
Synonym: BMS986195
Target: BTK
MYF-01-37
T22372
Synonym: 1-[3-Methyl-3-[3-(trifluoromethyl)anilino]pyrrolidin-1-yl]prop-2-en-1-one
Target: Others, YAP
6RK73
T10188
Synonym:
Target: Others
JH-X-119-01
T9203
Synonym:
Target: IRAK
SR 16832
T24827
Synonym: SR-16832,SR16832
Target: PPAR
DMH-25
T8569
Synonym:
Target: mTOR
Iadademstat dihydrochloride
T5825
Synonym: ORY-1001(trans)
Target: Histone Demethylase
COH000
T5199
Synonym:
Target: E1/E2/E3 Enzyme
ANT3310
T60050
Synonym:
Target: Antibacterial
Opnurasib
T40292
Synonym: NVP-JDQ443,JDQ-443,Opnurasib
Target: Ras
STING-IN-2
T9028
Synonym: C-170
Target: STING
1 2 3 4 5 6 7
Cat No. Product Name Synonyms Targets
T8307 Hydroxy-α-sanshool Hydroxy-​α-​sanshool Endogenous Metabolite , TRP/TRPV Channel
Hydroxy-α-sanshool is an alkyl amide isolated from the pepper. It acts as a TRPA1 covalent and TRPV1 non-covalent agonist (EC50s: 69 and 1.1 μM).
TN1620 Eriocalyxin B Apoptosis , cAMP , NF-κB , STAT
Eriocalyxin B induces apoptosis and cell cycle arrest in pancreatic adenocarcinoma cells through caspase- and p53-dependent pathways, should be considered a candidate for pancreatic cancer treatment; it is a specific inh...
T4889 2,6-Diaminoheptanedioic acid Others , Endogenous Metabolite
Diaminopimelic acid or DAPA is a lysine-like amino acid derivative that is a key component of the bacterial cell wall. DAPA is incorporated or integrated into peptidoglycan of gram negative bacteria and is the attachment...
T11555 Heptasaccharide Glc4Xyl3 Others
Heptasaccharide Glc4Xyl3 is a covalent inhibitor of endo-xyloglucanases. It used for the identification and analysis of diverse xyloglucan-active enzymes in nature.
TN4840 Psoromic acid Others
Psoromic acid is a selective and covalent rab-prenylation inhibitor targeting autoinhibited RabGGTase, it shows antibacterial activities against Streptococcus gordonii and Porphyromonas gingivalis, and it is an effective...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-01007 VEGFC Protein, Human, Recombinant (His) Human HEK293
Vascular endothelial growth factor C (VEGF-C) is a member of the VEGF family. Upon biosynthesis, VEGF-C protein is secreted as a non-covalent momodimer in an anti-parellel fashion. VEGF-C protein is a dimeric glycoprotei...
TMPY-03156 VEGFC Protein, Mouse/Rat, Recombinant (aa 108-223, His) Mouse,Rat HEK293
Vascular endothelial growth factor C (VEGF-C) is a member of the VEGF family. Upon biosynthesis, VEGF-C protein is secreted as a non-covalent momodimer in an anti-parellel fashion. VEGF-C protein is a dimeric glycoprotei...
TMPY-02521 HIST3H2A Protein, Human, Recombinant Human E. coli
Histones are a complex family of highly conserved basic proteins responsible for packaging chromosomal DNA into nucleosomes. There are subtype diversities: H1, H2A, H2B, and H3 or H4. It has become more and more evident ...
TMPY-01474 PAI-1 Protein, Human, Recombinant (His) Human HEK293
Plasminogen activator inhibitor 1, also known as PAI-1, Endothelial plasminogen activator inhibitor, SerpinE1 and PLANH1, is a secreted glycoprotein that belongs to the serpin family. SerpinE1 is the primary physiologica...
TMPH-03601 Streptavidin Protein, S. avidinii, Recombinant (His) Streptomyces avidinii Yeast
The biological function of streptavidin is not known. Forms a strong non-covalent specific complex with biotin (one molecule of biotin per subunit of streptavidin).
TMPH-03264 P53 Protein, Rat, Recombinant (His) Rat E. coli
Involved in phycobilisome (PBS) degradation during nutrient deprivation. May mark the PBS for degradation by covalent association with PBS components or may disrupt the PBS via ionic interactions.
TMPH-03253 BCAN Protein, Rat, Recombinant (His & Myc) Rat Baculovirus
The biological function of streptavidin is not known. Forms a strong non-covalent specific complex with biotin (one molecule of biotin per subunit of streptavidin).
TMPJ-01278 SENP8 Protein, Human, Recombinant (His) Human E. coli
Sentrin-Specific Protease 8 (SENP8) mediates the reversible covalent modification of proteins by NEDD8. SENP8 catalyzes the full-length NEDD8 to generate its mature form and deconjugation of NEDD8 from targeted proteins ...
TMPH-01149 Human coronavirus HKU1 (isolate N1) Spike glycoprotein (His & Myc) HCoV-HKU1 E. coli
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Me...
TMPH-00402 Classical swine fever virus Genome polyprotein (His) CSFV Baculovirus
Diphtheria toxin, produced by a phage infecting Corynebacterium diphtheriae, is a proenzyme that, after activation, catalyzes the covalent attachment of the ADP ribose moiety of NAD to elongation factor 2. Fragment A is ...
TMPJ-01221 UBE2J2 Protein, Human, Recombinant (GST) Human E. coli
Ubiquitin-Conjugating Enzyme E2 J2 (UBE2J2) belongs to the ubiquitin-conjugating enzyme family. UBE2J2 is involved in the ubiquitiantion. UBE2J2 located in the membrane of the endoplasmic reticulum, catalyzes the covalen...
TMPY-02842 UBE2L6 Protein, Human, Recombinant (His) Human E. coli
UBCH8, also known as UBE2L6, belongs to the ubiquitin-conjugating enzyme family. The family of ubiquitin-conjugating (E2) enzymes is characterized by the presence of a highly conserved ubiquitin-conjugating (UBC) domain....
TMPY-02129 Transglutaminase 3/TGM3 Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
Transglutaminases (TGase) are a family of calcium-dependent acyl-transfer enzymes ubiquitously expressed in mammalian cells and responsible for catalyzing covalent cross-links between proteins or peptides. Transglutamina...
TMPJ-01334 UBE2Z Protein, Human, Recombinant (His) Human E. coli
Ubiquitin-Conjugating Enzyme E2 Z (ZUBE2Z) is a member of the E2 ubiquitin-conjugating enzyme family. ZUBE2Z is widely expressed in many tissues, with high expression found in the placenta, pancreas, spleen, and testis. ...
TMPJ-01198 UBE2R2 Protein, Human, Recombinant (His) Human E. coli
Ubiquitin-Conjugating Enzyme E2 R2 (UBE2R2) is a modification enzyme that belongs to the ubiquitin-conjugating enzyme family. UBE2R2 is involved in cell growth and transformation. It accepts ubiquitin from the E1 complex...
TMPJ-00033 UBE2B Protein, Human, Recombinant (His) Human Human Cells
Ubiquitin-Conjugating Enzyme E2 B (UBE2B) is a member of the ubiquitin-conjugating enzyme family. UBE2B accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. It is shown that UBE2...
TMPJ-01069 Serpin A1e Protein, Mouse, Recombinant (His) Mouse Human Cells
Alpha-1-antitrypsin 1-5(SERPIN A1) is a secreted protein and belongs to the serpin family. Serpins bind the protease active site resulting in a major conformational rearrangement that traps the enzyme in a covalent acyl-...
TMPJ-00985 UBE2A Protein, Human, Recombinant (GST, His) Human E. coli
Ubiquitin-Conjugating Enzyme E2 (UBE2A) is a member of the E2 Ubiquitin-Conjugating Enzyme family. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived prot...
TMPH-01148 Human coronavirus HKU1 (isolate N1) Protein I (His) HCoV-HKU1 E. coli
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Me...
TMPJ-01362 UBAP1 Protein, Human, Recombinant (His) Human E. coli
Ubiquitin-Associated Protein 1 (UBAP1) belongs to the UBA domain family. Members of this family are related to ubiquitin and the ubiquitination pathway. Because of their cytogenetic location, this UBA domain family membe...
TMPH-01702 SMAD6 Protein, Human, Recombinant (E. coli, His & Myc) Human E. coli
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a p...
TMPJ-01403 UBE2D4 Protein, Human, Recombinant (GST) Human E. coli
Ubiquitin-Conjugating Enzyme E2 D4 (UBE2D4) is a ligase that belongs to the Ubiquitin-Conjugating Enzyme family. UBE2D4 has been proposed to participate in Ubl conjugation pathway. UBE2D4 takes part in post-translational...
TMPH-03575 Sortase A Protein, S. aureus, Recombinant (His) Staphylococcus aureus E. coli
Transpeptidase that anchors surface proteins to the cell wall. Recognizes and modifies its substrate by proteolytic cleavage of a C-terminal sorting signal. Following cleavage, a covalent intermediate is formed via a thi...
TMPH-03227 Rabies virus (RABV) (strain PM1503/AVO1) Matrix Protein (His) RABV E. coli
Transpeptidase that anchors surface proteins to the cell wall. Recognizes and modifies its substrate by proteolytic cleavage of a C-terminal sorting signal. Following cleavage, a covalent intermediate is formed via a thi...
TMPH-00921 IDUA Protein, Human, Recombinant (His) Human E. coli
Metalloprotease that plays key roles in regulating the formation of the extracellular matrix (ECM) via processing of various precursor proteins into mature functional enzymes or structural proteins. Thereby participates ...
TMPJ-01055 HBA1 Protein, Human, Recombinant (His) Human E. coli
Hemoglobin subunit alpha 1 (HBA1), also known as α2β2, is a hetero-tetramer consisting of two α and two β subunits held together by non-covalent interactions. Each subunit contains a heme group with an iron atom in the F...
TMPY-03155 VEGFC Protein, Mouse/Rat, Recombinant (aa 108-223, hFc) Mouse,Rat HEK293
Vascular endothelial growth factor C (VEGF-C) is a member of the VEGF family. Upon biosynthesis, VEGF-C protein is secreted as a non-covalent momodimer in an anti-parellel fashion. VEGF-C protein is a dimeric glycoprotei...
TMPY-00933 TIMP-2 Protein, Human, Recombinant (hFc) Human HEK293
Tissue inhibitors of metalloproteinases (TIMP) family are natural inhibitors of the matrix metalloproteinases (MMPs), the zinc enzymes involved in extracellular matrix maintenance and remodeling. The TIMP family encompas...
TMPH-03304 GRIN1 Protein, Rat, Recombinant (His) Rat E. coli
Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via tran...
TMPY-03700 S100A11 Protein, Mouse, Recombinant (His) Mouse E. coli
Protein S100-A11, also known as S100 calcium-binding protein A11, S100A11 and MLN70, is a member of theS-100 family. S100A11 is widely expressed in multiple tissues, and is located in cytoplasm, nucleus, and even cell pe...
TMPY-01868 TIMP-2 Protein, Human, Recombinant Human HEK293
Tissue inhibitors of metalloproteinases (TIMP) family are natural inhibitors of the matrix metalloproteinases (MMPs), the zinc enzymes involved in extracellular matrix maintenance and remodeling. The TIMP family encompas...
TMPY-03052 MFAP5 Protein, Human, Recombinant (His) Human HEK293
MFAP5 (Microfibril Associated Protein 5, also known as MAGP2) is a Protein Coding gene. MFAP5 is a component of the elastin-associated microfibrils. It belongs to the MFAP family. As a 25-kD microfibril-associated glycop...
TMPY-00323 Hepatitis C virus (HCV-1a) NS3 protease/helicase immunodominant region Protein (aa 1356-1459, GST) HCV E. coli
HCV NS3 displays three enzymatic activities: serine protease, NTPase, and RNA helicase. HCV NS3 serine protease, in association with NS4A, is responsible for the cleavages of NS3-NS4A, NS4A-NS4B, NS4B-NS5A, and NS5A-NS5B...
TMPY-01331 S100A11 Protein, Human, Recombinant Human E. coli
Protein S100-A11, also known as S100 calcium-binding protein A11, S100A11 and MLN70, is a member of theS-100 family. S100A11 is widely expressed in multiple tissues, and is located in cytoplasm, nucleus, and even cell pe...
TMPJ-01089 TFF1 Protein, Mouse, Recombinant (His) Mouse Human Cells
Trefoil Factor 1 (TFF1) belongs to the three structurally related secreted proteins that contain trefoil domains.TFF1 is an approximately peptide that has an important effect in epithelial regeneration and wound healing...
TMPJ-00486 SUMO2 Protein, Human, Recombinant (His) Human E. coli
Small Ubiquitin-Related Modifier 2 (SUMO2) is an Ubiquitin-like protein that belongs to the ubiquitin family with SUMO subfamily. It is a family of small, related proteins that can be enzymatically attached to a target p...
TMPY-02642 UBE2W Protein, Human, Recombinant (His) Human E. coli
Ubiquitin-conjugating enzymes, also known as UBE2W, E2 enzymes and more rarely as ubiquitin-carrier enzymes, perform the second step of protein ubiquitination. The modification of protein with ubiquitin is an important c...
TMPH-03056 Vacuolar protease A Protein, Neosartorya fumigata, Recombinant (His) Neosartorya fumigata E. coli
Receptor-activated non-selective cation channel involved in pain detection and possibly also in cold perception, oxygen concentration perception, cough, itch, and inner ear function. Shows 8-fold preference for divalent ...
TMPH-01127 COMMD5 Protein, Human, Recombinant (His) Human E. coli
Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via tran...
TMPY-02348 ISG15 Protein, Human, Recombinant Human E. coli
Interferon-induced 17 kDa protein (ISG15), a 15-kDa protein of unique primary amino acid sequence, functions intracellularly as a ubiquitin homolog and a cytokine that induces production of IFN-gamma and augments NK / ly...
TMPY-02467 ISG15 Protein, Human, Recombinant (mature form) Human E. coli
Interferon-induced 17 kDa protein (ISG15), a 15-kDa protein of unique primary amino acid sequence, functions intracellularly as a ubiquitin homolog and a cytokine that induces production of IFN-gamma and augments NK / ly...
TMPH-02703 HEBP1 Protein, Mouse, Recombinant (hFc) Mouse HEK293
Enoyl-ACP reductase of the type II fatty acid syntase (FAS-II) system, which is involved in the biosynthesis of mycolic acids, a major component of mycobacterial cell walls. Catalyzes the NADH-dependent reduction of the ...
TMPJ-01100 UBE2V1 Protein, Human, Recombinant (His) Human E. coli
Ubiquitin-Conjugating Enzyme Variant 1a (UBE2V1) is a member of the Ubiquitin-conjugating (E2) enzyme family. The E2 catalytic core domain of UBE2V1 lacks an active site cysteine residue, rendering it catalytically inact...
TMPH-00595 HtpG Protein, E. coli, Recombinant E. coli E. coli
An outer membrane lipoprotein that controls the distance between the inner and outer membranes; adding residues to Lpp increases the width of the periplasm. The only protein known to be covalently linked to the peptidogl...
TMPH-01153 Human coronavirus OC43 Nucleoprotein/NP Protein (His & Myc) HCoV-OC43 HEK293
E3 ubiquitin ligase required to protect genome stability in response to replication stress. Acts as a key regulator of interstrand cross-link repair, which takes place when both strands of duplex DNA are covalently tethe...
TMPY-00629 PAI-1 Protein, Rat, Recombinant (hFc) Rat HEK293
Plasminogen activator inhibitor 1, also known as PAI-1, Endothelial plasminogen activator inhibitor, SerpinE1 and PLANH1, is a secreted glycoprotein that belongs to the serpin family. SerpinE1 is the primary physiologica...
TMPY-02559 PAI-1 Protein, Rat, Recombinant (His) Rat HEK293
Plasminogen activator inhibitor 1, also known as PAI-1, Endothelial plasminogen activator inhibitor, SerpinE1 and PLANH1, is a secreted glycoprotein that belongs to the serpin family. SerpinE1 is the primary physiologica...
TMPH-02053 RBM14 Protein, Human, Recombinant (His & SUMO) Human E. coli
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11)...
TMPH-00639 Hygromycin-B 4-O-kinase Protein, E. coli, Recombinant (His) E. coli E. coli
With TolR probably plays a role in maintaining the position of the peptidoglycan cell wall in the periplasm (Probable). Plays a role in resistance to environmental stress, and a role in outer membrane functionality and c...
TMPH-02366 Junin mammarenavirus (JUNV) Nucleoprotein/NP Protein (His & SUMO) JUNV E. coli
Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Substrates include SYT11 and VDAC1. Other substrates are BCL2, CCNE1, GPR37, ...
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VEGFC Protein, Human, Recombinant (His)
TMPY-01007
Species: Human
Expression System: HEK293
VEGFC Protein, Mouse/Rat, Recombinant (aa 108-223, His)
TMPY-03156
Species: Mouse,Rat
Expression System: HEK293
HIST3H2A Protein, Human, Recombinant
TMPY-02521
Species: Human
Expression System: E. coli
PAI-1 Protein, Human, Recombinant (His)
TMPY-01474
Species: Human
Expression System: HEK293
Streptavidin Protein, S. avidinii, Recombinant (His)
TMPH-03601
Species: Streptomyces avidinii
Expression System: Yeast
p53 Protein, Rat, Recombinant (His)
TMPH-03264
Species: Rat
Expression System: E. coli
BCAN Protein, Rat, Recombinant (His & Myc)
TMPH-03253
Species: Rat
Expression System: Baculovirus
SENP8 Protein, Human, Recombinant (His)
TMPJ-01278
Species: Human
Expression System: E. coli
Human coronavirus HKU1 (isolate N1) Spike glycoprotein (His & Myc)
TMPH-01149
Species: HCoV-HKU1
Expression System: E. coli
Classical swine fever virus Genome polyprotein (His)
TMPH-00402
Species: CSFV
Expression System: Baculovirus
UBE2J2 Protein, Human, Recombinant (GST)
TMPJ-01221
Species: Human
Expression System: E. coli
UBE2L6 Protein, Human, Recombinant (His)
TMPY-02842
Species: Human
Expression System: E. coli
Transglutaminase 3/TGM3 Protein, Human, Recombinant (His)
TMPY-02129
Species: Human
Expression System: Baculovirus-Insect Cells
UBE2Z Protein, Human, Recombinant (His)
TMPJ-01334
Species: Human
Expression System: E. coli
UBE2R2 Protein, Human, Recombinant (His)
TMPJ-01198
Species: Human
Expression System: E. coli
UBE2B Protein, Human, Recombinant (His)
TMPJ-00033
Species: Human
Expression System: Human Cells
Serpin A1e Protein, Mouse, Recombinant (His)
TMPJ-01069
Species: Mouse
Expression System: Human Cells
UBE2A Protein, Human, Recombinant (GST, His)
TMPJ-00985
Species: Human
Expression System: E. coli
Human coronavirus HKU1 (isolate N1) Protein I (His)
TMPH-01148
Species: HCoV-HKU1
Expression System: E. coli
UBAP1 Protein, Human, Recombinant (His)
TMPJ-01362
Species: Human
Expression System: E. coli
SMAD6 Protein, Human, Recombinant (E. coli, His & Myc)
TMPH-01702
Species: Human
Expression System: E. coli
UBE2D4 Protein, Human, Recombinant (GST)
TMPJ-01403
Species: Human
Expression System: E. coli
Sortase A Protein, S. aureus, Recombinant (His)
TMPH-03575
Species: Staphylococcus aureus
Expression System: E. coli
Rabies virus (RABV) (strain PM1503/AVO1) Matrix Protein (His)
TMPH-03227
Species: RABV
Expression System: E. coli
IDUA Protein, Human, Recombinant (His)
TMPH-00921
Species: Human
Expression System: E. coli
HBA1 Protein, Human, Recombinant (His)
TMPJ-01055
Species: Human
Expression System: E. coli
VEGFC Protein, Mouse/Rat, Recombinant (aa 108-223, hFc)
TMPY-03155
Species: Mouse,Rat
Expression System: HEK293
TIMP-2 Protein, Human, Recombinant (hFc)
TMPY-00933
Species: Human
Expression System: HEK293
GRIN1 Protein, Rat, Recombinant (His)
TMPH-03304
Species: Rat
Expression System: E. coli
S100A11 Protein, Mouse, Recombinant (His)
TMPY-03700
Species: Mouse
Expression System: E. coli
TIMP-2 Protein, Human, Recombinant
TMPY-01868
Species: Human
Expression System: HEK293
MFAP5 Protein, Human, Recombinant (His)
TMPY-03052
Species: Human
Expression System: HEK293
Hepatitis C virus (HCV-1a) NS3 protease/helicase immunodominant region Protein (aa 1356-1459, GST)
TMPY-00323
Species: HCV
Expression System: E. coli
S100A11 Protein, Human, Recombinant
TMPY-01331
Species: Human
Expression System: E. coli
TFF1 Protein, Mouse, Recombinant (His)
TMPJ-01089
Species: Mouse
Expression System: Human Cells
SUMO2 Protein, Human, Recombinant (His)
TMPJ-00486
Species: Human
Expression System: E. coli
UBE2W Protein, Human, Recombinant (His)
TMPY-02642
Species: Human
Expression System: E. coli
Vacuolar protease A Protein, Neosartorya fumigata, Recombinant (His)
TMPH-03056
Species: Neosartorya fumigata
Expression System: E. coli
COMMD5 Protein, Human, Recombinant (His)
TMPH-01127
Species: Human
Expression System: E. coli
ISG15 Protein, Human, Recombinant
TMPY-02348
Species: Human
Expression System: E. coli
ISG15 Protein, Human, Recombinant (mature form)
TMPY-02467
Species: Human
Expression System: E. coli
HEBP1 Protein, Mouse, Recombinant (hFc)
TMPH-02703
Species: Mouse
Expression System: HEK293
UBE2V1 Protein, Human, Recombinant (His)
TMPJ-01100
Species: Human
Expression System: E. coli
HtpG Protein, E. coli, Recombinant
TMPH-00595
Species: E. coli
Expression System: E. coli
Human coronavirus OC43 Nucleoprotein/NP Protein (His & Myc)
TMPH-01153
Species: HCoV-OC43
Expression System: HEK293
PAI-1 Protein, Rat, Recombinant (hFc)
TMPY-00629
Species: Rat
Expression System: HEK293
PAI-1 Protein, Rat, Recombinant (His)
TMPY-02559
Species: Rat
Expression System: HEK293
RBM14 Protein, Human, Recombinant (His & SUMO)
TMPH-02053
Species: Human
Expression System: E. coli
Hygromycin-B 4-O-kinase Protein, E. coli, Recombinant (His)
TMPH-00639
Species: E. coli
Expression System: E. coli
Junin mammarenavirus (JUNV) Nucleoprotein/NP Protein (His & SUMO)
TMPH-02366
Species: JUNV
Expression System: E. coli
Cat No. Product Name
L9411 Cysteine Covalent Library

72 compounds
The cysteine covalent library contains 72 compounds.
L9410 Covalent Inhibitor Library

1949 compounds
A unique collection of 1949 covalent Inhibitors and other molecules with common warheads like chloroacetyl,2-Chloropropionyl,Acryloyl,sulfonyl fluoride, alkyne,acrylamide, ketocarbonyl,disulfide bond, etc.
L6150 Covalent Natural Product Library

596 compounds
Detialed biological information and pharmacological information of the products, providing theoretical direction and research basis for screening.
DO2200 Covalent inhibitors Library

12000 compounds
L7860 Mini Electrophilic Heterocyclic Fragment Library

369 compounds
369 compounds in total in the Highly Solubility Covalent Heterocyclic Fragment Library
L3500 Histone Modification Compound Library

480 compounds
A unique collection of 480 histone modification related compounds for high throughput screening (HTS) and high content screening (HCS);
L8600 Ubiquitination Compound Library

214 compounds
A unique collection of 214 ubiquitination related small chemicals can be used for high throughput and high content screening;
L8300 Chromatin Modification Compound Library

256 compounds
A unique collection of 256 compounds targeting chromatin remodeling pathway for high throughput screening (HTS) and high content screening (HCS);
TargetMol