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MS8511 HCl

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Purity:98.90%

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COA HNMR HPLC LCMS

MS8511 HCl

Catalog No. T63351L

MS8511 HCl is a selective and potent covalent inhibitor of G9a/GLP that acts by targeting cysteine residues in the substrate binding site. MS8511 has anticancer activity and antiproliferative activity and reduces intracellular H3K9me2 levels.MS8511 can be used to study a wide range of cancers including brain, breast, and ovarian cancers .

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Pack Size	Price	Availability
1 mg	$195	In Stock
5 mg	$483	In Stock
10 mg	$692	In Stock
25 mg	$1,080	In Stock
50 mg	$1,490	In Stock
100 mg	$1,970	In Stock

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Product Introduction

Bioactivity

Description	MS8511 HCl is a selective and potent covalent inhibitor of G9a/GLP that acts by targeting cysteine residues in the substrate binding site. MS8511 has anticancer activity and antiproliferative activity and reduces intracellular H3K9me2 levels.MS8511 can be used to study a wide range of cancers including brain, breast, and ovarian cancers .
In vitro	MS8511 HCl (Compound 8), within a range of 0-100 μM over 10 minutes, selectively inhibits G9a and GLP compared to other PKMTs and PRMTs, with IC50 values of 100 nM (G9a) and 140 nM (GLP) [1].With a duration of 50 minutes, MS8511 HCl exhibits a preference for covalent modification of G9a over GLP, with Kd values of 44 nM (G9a) and 46 nM (GLP) [1].Over a range of 0-5 μM and durations of 24-72 hours,MS8511 HCl effectively reduces the H3K9me2 mark in MDA-MB-231 and K562 cells [1]. At concentrations ranging from 0.8 to 25 μM over a period of 3 days, MS8511 HCl inhibits the growth of MDA-MB-231 cells [1].
Alias	MS8511 HCl(2866408-21-9 Free base)

Chemical Properties

Molecular Weight	532.12
Formula	C28H42ClN5O3
Cas No.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

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