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ORIC-944

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Catalog No. T87073Cas No. 2369769-29-7
Alias ORIC944

ORIC-944 is an orally available and selective variant of PRC2 with anticancer activity for prostate cancer research.

ORIC-944

ORIC-944

🥰Excellent
Catalog No. T87073Alias ORIC944Cas No. 2369769-29-7
ORIC-944 is an orally available and selective variant of PRC2 with anticancer activity for prostate cancer research.
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Product Introduction

Bioactivity
Description
ORIC-944 is an orally available and selective variant of PRC2 with anticancer activity for prostate cancer research.
In vivo
Single agent tumor growth inhibition was observed for ORIC-944 in prostate cancer xenograft models. ORIC-944 also improved ARPI antitumor activity in preclinical combination studies and demonstrated in vitro synergy. [2]
AliasORIC944
Chemical Properties
Molecular Weight456.52
FormulaC26H25FN6O
Cas No.2369769-29-7
SmilesN#CC=1N=C2C(=CN=C(NCC=3C(F)=CC=C4OCCC43)N2C1)C5=CC=C(C=C5C)CN(C)C
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 80.00 mg/mL (175.24 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1905 mL10.9524 mL21.9048 mL109.5242 mL
5 mM0.4381 mL2.1905 mL4.3810 mL21.9048 mL
10 mM0.2190 mL1.0952 mL2.1905 mL10.9524 mL
20 mM0.1095 mL0.5476 mL1.0952 mL5.4762 mL
50 mM0.0438 mL0.2190 mL0.4381 mL2.1905 mL
100 mM0.0219 mL0.1095 mL0.2190 mL1.0952 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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