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Product Introduction

Bioactivity

Description	Piribedil (Trivastan) is a dopamine D2 agonist, used in the treatment of Parkinson's disease.
Targets&IC50	α2C-adrenoceptor:7.2(pKi), D2 receptor:6.9(pKi), α2A-adrenoceptor:7.1(pKi)
Alias	Trivastan, Trivastal, EU-4200, ET-495

Chemical Properties

Molecular Weight	298.34
Formula	C₁₆H₁₈N₄O₂
Cas No.	3605-01-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

Chloroform: Soluble

DMSO: 18.33 mg/mL (61.45 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3519 mL	16.7594 mL	33.5188 mL	167.5940 mL
5 mM	0.6704 mL	3.3519 mL	6.7038 mL	33.5188 mL
10 mM	0.3352 mL	1.6759 mL	3.3519 mL	16.7594 mL
20 mM	0.1676 mL	0.8380 mL	1.6759 mL	8.3797 mL
50 mM	0.0670 mL	0.3352 mL	0.6704 mL	3.3519 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc