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BI-2865 is a non-covalent pan-KRAS inhibitor.BI-2865 binds to KRAS WT, G12C, G12D, G12V, and G13D mutants with KD values of 6.9, 4.5, 32, 26, and 4.3 nM, respectively.BI-2865 showed antiproliferative activity in BaF3 cells expressing KRAS G12C, G12D, or G12V mutants[1] . BI-2865 showed antiproliferative activity on BaF3 cells expressing KRAS G12C, G12D or G12V mutants, with an average IC50 value of approximately 140 nM.[1]
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | 216 € | In Stock | |
5 mg | 546 € | In Stock | |
10 mg | 660 € | In Stock | |
25 mg | 978 € | In Stock | |
50 mg | 1.292 € | In Stock | |
100 mg | 1.757 € | In Stock | |
1 mL x 10 mM (in DMSO) | 549 € | In Stock |
Description | BI-2865 is a non-covalent pan-KRAS inhibitor.BI-2865 binds to KRAS WT, G12C, G12D, G12V, and G13D mutants with KD values of 6.9, 4.5, 32, 26, and 4.3 nM, respectively.BI-2865 showed antiproliferative activity in BaF3 cells expressing KRAS G12C, G12D, or G12V mutants[1] . BI-2865 showed antiproliferative activity on BaF3 cells expressing KRAS G12C, G12D or G12V mutants, with an average IC50 value of approximately 140 nM.[1] |
In vitro | METHODS: BaF3 cells expressing isogenic KRAS mutants of the indicated KRAS or expressing G12C, G12D or G12V mutant KRAS were treated in the absence of IL3 for 5 days to determine the effect on proliferation. RESULTS BI-2865 inhibited the proliferation of isogenic G12C, G12D or G12V mutant KRAS expressing BaF3 with an IC50 value of 140 nM. [1] |
Molecular Weight | 465.57 |
Formula | C23H27N7O2S |
Cas No. | 2937327-93-8 |
Smiles | C[C@]1(C2=C(SC(N)=C2C#N)CCC1)C3=NC(=NO3)C=4N=C(O[C@@H](C)[C@@]5(CCCN5C)[H])C=CN4 |
Relative Density. | 1.38 g/cm3 at 20℃ (Predicted) |
Storage | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 225.0 mg/mL (483.3 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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