Shopping Cart

Remove All

Your shopping cart is currently empty

BI-2865

Select Batch

Purity:99.39%

Resource Download

COA HPLC HNMR

BI-2865

Catalog No. T72062Cas No. 2937327-93-8

BI-2865 is a non-covalent pan-KRAS inhibitor.BI-2865 binds to KRAS WT, G12C, G12D, G12V, and G13D mutants with KD values of 6.9, 4.5, 32, 26, and 4.3 nM, respectively.BI-2865 showed antiproliferative activity in BaF3 cells expressing KRAS G12C, G12D, or G12V mutants. BI-2865 showed antiproliferative activity on BaF3 cells expressing KRAS G12C, G12D or G12V mutants with an average IC50 value of approximately 140 nM.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$228	In Stock
5 mg	$575	In Stock
10 mg	$695	In Stock
25 mg	$1,030	In Stock
50 mg	$1,360	In Stock
100 mg	$1,850	In Stock
1 mL x 10 mM (in DMSO)	$578	In Stock

Bulk & Custom

Add to Cart

Questions

Related Compound Libraries of "BI-2865"

Product Introduction

Bioactivity

Description

In vitro

BI-2865 inhibits the proliferation of BaF3 cells expressing G12C, G12D or G12V mutant KRAS in the presence of IL-13 with a mean IC50 of approximately 140 nM.[1]

Chemical Properties

Molecular Weight	465.57
Formula	C23H27N7O2S
Cas No.	2937327-93-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 225.0 mg/mL (483.3 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1479 mL	10.7395 mL	21.4790 mL	107.3952 mL
5 mM	0.4296 mL	2.1479 mL	4.2958 mL	21.4790 mL
10 mM	0.2148 mL	1.0740 mL	2.1479 mL	10.7395 mL
20 mM	0.1074 mL	0.5370 mL	1.0740 mL	5.3698 mL
50 mM	0.0430 mL	0.2148 mL	0.4296 mL	2.1479 mL
100 mM	0.0215 mL	0.1074 mL	0.2148 mL	1.0740 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc