Shopping Cart

Remove All
Your shopping cart is currently empty

BI-2493

BI-2493 is a highly selective pan-KRAS inhibitor and structural analog of BI-2865.BI-2493 exhibits antitumor activity and inhibits tumor cell growth and can be used in the study of cancerous diseases.BI-2493 is a highly selective pan-KRAS inhibitor and structural analog of BI-2865.

Catalog No. T72061Cas No. 2937344-16-4

Select Batch

Purity:99.49%

ee:100%

Resource Download

COA CSFC HNMR HPLC LCMS

BI-2493

Catalog No. T72061Cas No. 2937344-16-4

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$630	In Stock
5 mg	$1,550	In Stock
10 mg	$2,480	In Stock
25 mg	$3,680	In Stock
50 mg	$4,900	In Stock
100 mg	$6,630	In Stock

Bulk & Custom

Add to Cart

Questions

Related Compound Libraries of "BI-2493"

Product Introduction

Bioactivity

Description	BI-2493 is a highly selective pan-KRAS inhibitor and structural analog of BI-2865.BI-2493 exhibits antitumor activity and inhibits tumor cell growth and can be used in the study of cancerous diseases.BI-2493 is a highly selective pan-KRAS inhibitor and structural analog of BI-2865.
In vitro	BI-2493 inhibits the proliferation with IC50 values < 140 nM in Ba/F3 cell lines made dependent on KRAS by transfection of different mutant KRAS oncogenes (e.g., KRAS G12C, KRAS G12D, KRAS G12V)[1].
In vivo	BI-2493 (90 mg/kg; gavage) attenuats tumour growth in mice bearing KRAS G12C, G12D, G12V and A146V mutant models, without causing apparent toxicity to the mice[1].

Chemical Properties

Molecular Weight	461.58
Formula	C₂₄H₂₇N₇OS
Cas No.	2937344-16-4

Storage & Solubility Information

Storage

Shipping with blue ice.

Solubility Information

DMSO: 60 mg/mL (129.99 mM), Sonication and heating are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1665 mL	10.8324 mL	21.6647 mL	108.3236 mL
5 mM	0.4333 mL	2.1665 mL	4.3329 mL	21.6647 mL
10 mM	0.2166 mL	1.0832 mL	2.1665 mL	10.8324 mL
20 mM	0.1083 mL	0.5416 mL	1.0832 mL	5.4162 mL
50 mM	0.0433 mL	0.2166 mL	0.4333 mL	2.1665 mL
100 mM	0.0217 mL	0.1083 mL	0.2166 mL	1.0832 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc