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BI-2493
🥰Excellent
Catalog No. T72061Cas No. 2937344-16-4
BI-2493 is a highly selective pan-KRAS inhibitor and structural analog of BI-2865.BI-2493 exhibits antitumor activity and inhibits tumor cell growth and can be used in the study of cancerous diseases.BI-2493 is a highly selective pan-KRAS inhibitor and structural analog of BI-2865.
BI-2493
🥰Excellent
Purity: 99.49%
Catalog No. T72061Cas No. 2937344-16-4
BI-2493 is a highly selective pan-KRAS inhibitor and structural analog of BI-2865.BI-2493 exhibits antitumor activity and inhibits tumor cell growth and can be used in the study of cancerous diseases.BI-2493 is a highly selective pan-KRAS inhibitor and structural analog of BI-2865.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $630 | In Stock | |
| 5 mg | $1,550 | In Stock | |
| 10 mg | $2,480 | In Stock | |
| 25 mg | $3,680 | In Stock | |
| 50 mg | $4,900 | In Stock | |
| 100 mg | $6,630 | In Stock |
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Purity:99.49%
ee:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | BI-2493 is a highly selective pan-KRAS inhibitor and structural analog of BI-2865.BI-2493 exhibits antitumor activity and inhibits tumor cell growth and can be used in the study of cancerous diseases.BI-2493 is a highly selective pan-KRAS inhibitor and structural analog of BI-2865. |
| In vitro | METHODS: ASPC1, HPAC and H727 cells were treated with BI-2493 (Log (1-4nM)), and cell viability was detected after 72 hours. RESULTS BI-2493 inhibited the growth of ASPC1, HPAC and H727 cells. [1] |
| In vivo | METHODS: A cell line-derived xenograft model was established, and mice were randomly assigned according to tumor size (n = 7-8 mice per treatment group) and treated with BI-2493 (10-90 mg/kg, orally twice daily) . RESULTS BI-2493 attenuated tumor growth in xenograft model mice. [1] |
| Molecular Weight | 461.58 |
| Formula | C24H27N7OS |
| Cas No. | 2937344-16-4 |
| Smiles | C(#N)C=1C=2[C@@]3(C4=C(C(=NO4)C5=NC(=NC=C5)N6[C@@H](C)CNCC6)CCC3)CCCC2SC1N |
| Relative Density. | 1.41 g/cm3 at 20℃ (Predicted) |
Storage & Solubility Information
| Storage | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 60 mg/mL (129.99 mM), Sonication and heating are recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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