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SRPKIN-1

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Catalog No. T16931Cas No. 2089226-94-6

SRPKIN-1 is a covalent and irreversible inhibitor of SRPK1/2 (IC50s: 35.6 and 98 nM, respectively).

SRPKIN-1

SRPKIN-1

😃Good
Catalog No. T16931Cas No. 2089226-94-6
SRPKIN-1 is a covalent and irreversible inhibitor of SRPK1/2 (IC50s: 35.6 and 98 nM, respectively).
Pack SizePriceAvailabilityQuantity
5 mg$1,1706-8 weeks
25 mg$1,9696-8 weeks
50 mg$2,3806-8 weeks
100 mg$3,1006-8 weeks
1 mL x 10 mM (in DMSO)$1,2896-8 weeks
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Product Introduction

Bioactivity
Description
SRPKIN-1 is a covalent and irreversible inhibitor of SRPK1/2 (IC50s: 35.6 and 98 nM, respectively).
Targets&IC50
SRPK2:98 nM, SRPK1:35.6 nM
In vitro
SRPK-IN-1 effectively converts VEGF from pro-angiogenic to anti-angiogenic isoform. SRPKIN-1 treatment at 200 nM (10, 50, 100, 200 nM, 16 hours) obviously decreases SR protein phosphorylation at the steady-state with or without washout [1].
In vivo
SRPKIN-1 (50 nM, 300 nM,1 μL, 5 times) blocks angiogenesis through VEGF alternative splicing in a CNV mouse model [1].
Chemical Properties
Molecular Weight472.53
FormulaC27H21FN2O3S
Cas No.2089226-94-6
Relative Density.1.43 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 110 mg/mL (232.79 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1163 mL10.5813 mL21.1627 mL105.8134 mL
5 mM0.4233 mL2.1163 mL4.2325 mL21.1627 mL
10 mM0.2116 mL1.0581 mL2.1163 mL10.5813 mL
20 mM0.1058 mL0.5291 mL1.0581 mL5.2907 mL
50 mM0.0423 mL0.2116 mL0.4233 mL2.1163 mL
100 mM0.0212 mL0.1058 mL0.2116 mL1.0581 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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