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Chst15-IN-1

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Catalog No. T39631Cas No. 2158198-77-5
Alias Chst15-IN-1

Chst15-IN-1 is a powerful, reversible, covalent inhibitor of the Chst15 enzyme. It effectively suppresses the sulfation levels of chondroitin sulfate-E (CS-E) and other closely related sulfotransferases responsible for glycosaminoglycans (GAGs) synthesis. Acting as a selective sulfotransferase inhibitor, Chst15-IN-1 can attenuate the inhibitory actions of chondroitin sulfate proteoglycans (CSPGs), making it a promising candidate for enhancing neuronal repair.

Chst15-IN-1

Chst15-IN-1

😃Good
Catalog No. T39631Alias Chst15-IN-1Cas No. 2158198-77-5
Chst15-IN-1 is a powerful, reversible, covalent inhibitor of the Chst15 enzyme. It effectively suppresses the sulfation levels of chondroitin sulfate-E (CS-E) and other closely related sulfotransferases responsible for glycosaminoglycans (GAGs) synthesis. Acting as a selective sulfotransferase inhibitor, Chst15-IN-1 can attenuate the inhibitory actions of chondroitin sulfate proteoglycans (CSPGs), making it a promising candidate for enhancing neuronal repair.
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2 mg$535 days
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Product Introduction

Bioactivity
Description
Chst15-IN-1 is a powerful, reversible, covalent inhibitor of the Chst15 enzyme. It effectively suppresses the sulfation levels of chondroitin sulfate-E (CS-E) and other closely related sulfotransferases responsible for glycosaminoglycans (GAGs) synthesis. Acting as a selective sulfotransferase inhibitor, Chst15-IN-1 can attenuate the inhibitory actions of chondroitin sulfate proteoglycans (CSPGs), making it a promising candidate for enhancing neuronal repair.
In vitro
Chst15-IN-1, at concentrations of 25 μM for 24 hours in Neu7 astrocytes, demonstrates selectivity for sulfotransferases compared to a wide range of cysteine-reactive proteins. Furthermore, Chst15-IN-1 exhibits a significant dose-dependent reduction in cell-surface CS-E expression in Neu7 astrocytes at both 10 and 25 μM concentrations[1].
In vivo
Chst15-IN-1 (3.0 mg/kg; i.v.) shows a moderate clearance rate of 21 mL/min/kg, a moderate volume of distribution at 0.97 L/kg, and a short terminal half-life of 1.6 hours in rats during pharmacokinetic analysis, summarizing its efficacy and disposition within the tested animal model[1].
AliasChst15-IN-1
Chemical Properties
Molecular Weight442.09
FormulaC17H11BrCl2N2O3
Cas No.2158198-77-5
Relative Density.1.677 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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Keywords

Chst15IN1Chst15 IN 1Chst-15-IN-1
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