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AA147

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Purity:99.79%

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COA HNMR HPLC

AA147

Catalog No. T14080Cas No. 393121-74-9

AA147 (ATF6-activator-147) is a small molecule endoplasmic reticulum (ER) proteostasis regulator. The selectively activates ATF6 arm of the unfolded protein response (UPR) .It acts as a prodrug that preferentially triggers ATF6 signaling through a mechanism involving localized metabolic activation and selective covalent modification of ER resident proteins that regulate ATF6 activity.

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Pack Size	Price	Availability
5 mg	$57	In Stock
10 mg	$97	In Stock
25 mg	$188	In Stock
50 mg	$279	In Stock
100 mg	$416	In Stock
500 mg	$942	In Stock
1 mL x 10 mM (in DMSO)	$63	In Stock

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Product Introduction

Bioactivity

Description	AA147 (ATF6-activator-147) is a small molecule endoplasmic reticulum (ER) proteostasis regulator. The selectively activates ATF6 arm of the unfolded protein response (UPR) .It acts as a prodrug that preferentially triggers ATF6 signaling through a mechanism involving localized metabolic activation and selective covalent modification of ER resident proteins that regulate ATF6 activity.
Alias	ATF6-activator-147

Chemical Properties

Molecular Weight	255.31
Formula	C16H17NO2
Cas No.	393121-74-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 25 mg/mL (97.92 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9168 mL	19.5840 mL	39.1681 mL	195.8404 mL
5 mM	0.7834 mL	3.9168 mL	7.8336 mL	39.1681 mL
10 mM	0.3917 mL	1.9584 mL	3.9168 mL	19.5840 mL
20 mM	0.1958 mL	0.9792 mL	1.9584 mL	9.7920 mL
50 mM	0.0783 mL	0.3917 mL	0.7834 mL	3.9168 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

neurodegenerative disordersSMAATF6BPAECNRF2AA-147InhibitorAA 147inhibitROSAA147