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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $227 | Backorder | |
10 mg | $386 | Backorder | |
50 mg | Inquiry | Backorder | |
100 mg | Inquiry | Backorder | |
1 mL x 10 mM (in DMSO) | $314 | Backorder |
Description | YKL-5-124 TFA is a potent, selective, irreversible and covalent inhibitor of CDK7 (IC50s of 53.5 nM and 9.7 nM for CDK7 and CDK7/Mat1/CycH, respectively). |
Targets&IC50 | CDK2:1300 nM, CDK9:3020 nM, CDK7-CyclinH-MAT1:9.7 nM, CDK7:53.5 nM |
In vitro | In G1- and G2/M-phase cells and a corresponding loss of S-phase cells, YKL-5-124 (0-2000 nM; 72 hours; HAP1 cells) treatment causes a dose-dependent increase . YKL-5-124 (0-2000 nM; 24 hours; HAP1 WT cells) treatment inhibits CDK1 T-loop phosphorylation, and to a lesser extent CDK2 T-loop phosphorylation in a concentration-dependent fashion. |
Alias | YKL-5-124 TFA |
Molecular Weight | 629.63 |
Formula | C30H34F3N7O5 |
Cas No. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 100 mg/mL (158.82 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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