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YKL-5-124 TFA (1957203-01-8 free base)

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YKL-5-124 TFA (1957203-01-8 free base)

Catalog No. T13367

YKL-5-124 TFA is a potent, selective, irreversible and covalent inhibitor of CDK7 (IC50s of 53.5 nM and 9.7 nM for CDK7 and CDK7/Mat1/CycH, respectively).

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Pack Size	Price	Availability
5 mg	$227	Backorder
10 mg	$386	Backorder
50 mg	Inquiry	Backorder
100 mg	Inquiry	Backorder
1 mL x 10 mM (in DMSO)	$314	Backorder

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Product Introduction

Bioactivity

Description	YKL-5-124 TFA is a potent, selective, irreversible and covalent inhibitor of CDK7 (IC50s of 53.5 nM and 9.7 nM for CDK7 and CDK7/Mat1/CycH, respectively).
Targets&IC50	CDK2:1300 nM, CDK9:3020 nM, CDK7-CyclinH-MAT1:9.7 nM, CDK7:53.5 nM
In vitro	In G1- and G2/M-phase cells and a corresponding loss of S-phase cells, YKL-5-124 (0-2000 nM; 72 hours; HAP1 cells) treatment causes a dose-dependent increase . YKL-5-124 (0-2000 nM; 24 hours; HAP1 WT cells) treatment inhibits CDK1 T-loop phosphorylation, and to a lesser extent CDK2 T-loop phosphorylation in a concentration-dependent fashion.
Alias	YKL-5-124 TFA

Chemical Properties

Molecular Weight	629.63
Formula	C30H34F3N7O5
Cas No.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 100 mg/mL (158.82 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5882 mL	7.9412 mL	15.8823 mL	79.4117 mL
5 mM	0.3176 mL	1.5882 mL	3.1765 mL	15.8823 mL
10 mM	0.1588 mL	0.7941 mL	1.5882 mL	7.9412 mL
20 mM	0.0794 mL	0.3971 mL	0.7941 mL	3.9706 mL
50 mM	0.0318 mL	0.1588 mL	0.3176 mL	1.5882 mL
100 mM	0.0159 mL	0.0794 mL	0.1588 mL	0.7941 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

YKL5124 TFA (1957203018 free base)YKL 5 124 TFA (1957203 01 8 free base)1957203-01-81957203-01-8 free base

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