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FMF-04-159-2

🥰Excellent
Catalog No. T11309Cas No. 2364489-81-4

FMF-04-159-2 is a potent covalent cell cycle protein-dependent kinase 14 (CDK14) inhibitor with IC₅₀ of 39.6 nM for CDK14 and 256 nM for CDK2.FMF-04-159-2 is able to reduce α-synuclein (α-Syn ) aggregation in neurons and plays a role in Parkinson's disease models, and also inhibits triple-negative breast cancer (TNBC) progression and metastasis by attenuating Wnt/β-catenin signaling.

FMF-04-159-2

FMF-04-159-2

🥰Excellent
Catalog No. T11309Cas No. 2364489-81-4
FMF-04-159-2 is a potent covalent cell cycle protein-dependent kinase 14 (CDK14) inhibitor with IC₅₀ of 39.6 nM for CDK14 and 256 nM for CDK2.FMF-04-159-2 is able to reduce α-synuclein (α-Syn ) aggregation in neurons and plays a role in Parkinson's disease models, and also inhibits triple-negative breast cancer (TNBC) progression and metastasis by attenuating Wnt/β-catenin signaling.
Pack SizePriceAvailabilityQuantity
2 mg$50 In Stock
5 mg$83 In Stock
10 mg$148 In Stock
25 mg$313 In Stock
50 mg$549 In Stock
100 mg$958 In Stock
1 mL x 10 mM (in DMSO)$118 In Stock
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Product Introduction

Bioactivity
Description
FMF-04-159-2 is a potent covalent cell cycle protein-dependent kinase 14 (CDK14) inhibitor with IC₅₀ of 39.6 nM for CDK14 and 256 nM for CDK2.FMF-04-159-2 is able to reduce α-synuclein (α-Syn ) aggregation in neurons and plays a role in Parkinson's disease models, and also inhibits triple-negative breast cancer (TNBC) progression and metastasis by attenuating Wnt/β-catenin signaling.
Targets&IC50
CDK14-CyclinY:39.6 nM (in NanoBRET assay) , CDK2:256 nM (in NanoBRET assay), CDK14-CyclinY:39.6 nM, CDK2:256 nM
In vitro
FMF-04-159-2 inhibits HCT116 cell proliferation with an IC50 of 1,144±190 nM.
Chemical Properties
Molecular Weight683.01
FormulaC28H30Cl3N7O5S
Cas No.2364489-81-4
SmilesN(C(=O)C1=C(Cl)C=C(Cl)C=C1Cl)C=2C(C(NC3CCN(S(=O)(=O)C4=CC(NC(/C=C/CN(C)C)=O)=CC=C4)CC3)=O)=NNC2
Relative Density.1.53 g/cm3 (Predicted)
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 200 mg/mL (292.82 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.4641 mL7.3205 mL14.6411 mL73.2054 mL
5 mM0.2928 mL1.4641 mL2.9282 mL14.6411 mL
10 mM0.1464 mL0.7321 mL1.4641 mL7.3205 mL
20 mM0.0732 mL0.3660 mL0.7321 mL3.6603 mL
50 mM0.0293 mL0.1464 mL0.2928 mL1.4641 mL
100 mM0.0146 mL0.0732 mL0.1464 mL0.7321 mL

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