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FMF-04-159-2
🥰Excellent
Catalog No. T11309Cas No. 2364489-81-4
FMF-04-159-2 is a potent covalent cell cycle protein-dependent kinase 14 (CDK14) inhibitor with IC₅₀ of 39.6 nM for CDK14 and 256 nM for CDK2.FMF-04-159-2 is able to reduce α-synuclein (α-Syn ) aggregation in neurons and plays a role in Parkinson's disease models, and also inhibits triple-negative breast cancer (TNBC) progression and metastasis by attenuating Wnt/β-catenin signaling.
FMF-04-159-2
🥰Excellent
Catalog No. T11309Cas No. 2364489-81-4
FMF-04-159-2 is a potent covalent cell cycle protein-dependent kinase 14 (CDK14) inhibitor with IC₅₀ of 39.6 nM for CDK14 and 256 nM for CDK2.FMF-04-159-2 is able to reduce α-synuclein (α-Syn ) aggregation in neurons and plays a role in Parkinson's disease models, and also inhibits triple-negative breast cancer (TNBC) progression and metastasis by attenuating Wnt/β-catenin signaling.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $50 | In Stock | |
| 5 mg | $83 | In Stock | |
| 10 mg | $148 | In Stock | |
| 25 mg | $313 | In Stock | |
| 50 mg | $549 | In Stock | |
| 100 mg | $958 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $118 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | FMF-04-159-2 is a potent covalent cell cycle protein-dependent kinase 14 (CDK14) inhibitor with IC₅₀ of 39.6 nM for CDK14 and 256 nM for CDK2.FMF-04-159-2 is able to reduce α-synuclein (α-Syn ) aggregation in neurons and plays a role in Parkinson's disease models, and also inhibits triple-negative breast cancer (TNBC) progression and metastasis by attenuating Wnt/β-catenin signaling. |
| Targets&IC50 | CDK14-CyclinY:39.6 nM (in NanoBRET assay) , CDK2:256 nM (in NanoBRET assay), CDK14-CyclinY:39.6 nM, CDK2:256 nM |
| In vitro | FMF-04-159-2 can inhibit the proliferation of HCT116 cells with an IC50 of 1,144±190 nM. [1] |
| Molecular Weight | 683.01 |
| Formula | C28H30Cl3N7O5S |
| Cas No. | 2364489-81-4 |
| Smiles | N(C(=O)C1=C(Cl)C=C(Cl)C=C1Cl)C=2C(C(NC3CCN(S(=O)(=O)C4=CC(NC(/C=C/CN(C)C)=O)=CC=C4)CC3)=O)=NNC2 |
| Relative Density. | 1.53 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 200 mg/mL (292.82 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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