Shopping Cart
- Remove All
- Your shopping cart is currently empty
FMF-04-159-2 is a potent covalent cell cycle protein-dependent kinase 14 (CDK14) inhibitor with IC₅₀ of 39.6 nM for CDK14 and 256 nM for CDK2.FMF-04-159-2 is able to reduce α-synuclein (α-Syn ) aggregation in neurons and plays a role in Parkinson's disease models, and also inhibits triple-negative breast cancer (TNBC) progression and metastasis by attenuating Wnt/β-catenin signaling.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $50 | In Stock | |
5 mg | $83 | In Stock | |
10 mg | $148 | In Stock | |
25 mg | $313 | In Stock | |
50 mg | $549 | In Stock | |
100 mg | $958 | In Stock | |
1 mL x 10 mM (in DMSO) | $118 | In Stock |
Description | FMF-04-159-2 is a potent covalent cell cycle protein-dependent kinase 14 (CDK14) inhibitor with IC₅₀ of 39.6 nM for CDK14 and 256 nM for CDK2.FMF-04-159-2 is able to reduce α-synuclein (α-Syn ) aggregation in neurons and plays a role in Parkinson's disease models, and also inhibits triple-negative breast cancer (TNBC) progression and metastasis by attenuating Wnt/β-catenin signaling. |
Targets&IC50 | CDK14-CyclinY:39.6 nM (in NanoBRET assay) , CDK2:256 nM (in NanoBRET assay), CDK14-CyclinY:39.6 nM, CDK2:256 nM |
In vitro | FMF-04-159-2 inhibits HCT116 cell proliferation with an IC50 of 1,144±190 nM. |
Molecular Weight | 683.01 |
Formula | C28H30Cl3N7O5S |
Cas No. | 2364489-81-4 |
Smiles | N(C(=O)C1=C(Cl)C=C(Cl)C=C1Cl)C=2C(C(NC3CCN(S(=O)(=O)C4=CC(NC(/C=C/CN(C)C)=O)=CC=C4)CC3)=O)=NNC2 |
Relative Density. | 1.53 g/cm3 (Predicted) |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 200 mg/mL (292.82 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
|
Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.