FMF-04-159-2

Name: FMF-04-159-2
Brand: TargetMol
SKU: T11309
Rating: 4.5 (1 reviews)

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Catalog No. T11309Cas No. 2364489-81-4

FMF-04-159-2 inhibits CDK14 and CDK2 with IC50s of 39.6 nM and 256 nM in NanoBRET assay, respectively. FMF-04-159-2 is a covalent CDK14 inhibitor.

FMF-04-159-2

🥰Excellent

Catalog No. T11309Cas No. 2364489-81-4

FMF-04-159-2 inhibits CDK14 and CDK2 with IC50s of 39.6 nM and 256 nM in NanoBRET assay, respectively. FMF-04-159-2 is a covalent CDK14 inhibitor.

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Product Introduction

Bioactivity

Description	FMF-04-159-2 inhibits CDK14 and CDK2 with IC50s of 39.6 nM and 256 nM in NanoBRET assay, respectively. FMF-04-159-2 is a covalent CDK14 inhibitor.
Targets&IC50	CDK14-CyclinY:39.6 nM (in NanoBRET assay) , CDK2:256 nM (in NanoBRET assay)
In vitro	FMF-04-159-2 inhibits HCT116 cell proliferation with an IC50 of 1,144±190 nM.

Chemical Properties

Molecular Weight	683.01
Formula	C₂₈H₃₀Cl₃N₇O₅S
Cas No.	2364489-81-4
Relative Density.	1.53 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 250 mg/mL (366.03 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4641 mL	7.3205 mL	14.6411 mL	73.2054 mL
5 mM	0.2928 mL	1.4641 mL	2.9282 mL	14.6411 mL
10 mM	0.1464 mL	0.7321 mL	1.4641 mL	7.3205 mL
20 mM	0.0732 mL	0.3660 mL	0.7321 mL	3.6603 mL
50 mM	0.0293 mL	0.1464 mL	0.2928 mL	1.4641 mL
100 mM	0.0146 mL	0.0732 mL	0.1464 mL	0.7321 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc