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SARS-CoV-2 3CLpro-IN-5
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Catalog No. T72364Cas No. 2913186-57-7
SARS-CoV-2 3CLpro-IN-5 is a covalent inhibitor targeting the 3C-like protease (3CLpro), with potent inhibitory activity (IC50: 3.8 nM) and 9.0% oral bioavailability (BA), used in COVID-19 research [1].
SARS-CoV-2 3CLpro-IN-5
SARS-CoV-2 3CLpro-IN-5
😃Good
Catalog No. T72364Cas No. 2913186-57-7
SARS-CoV-2 3CLpro-IN-5 is a covalent inhibitor targeting the 3C-like protease (3CLpro), with potent inhibitory activity (IC50: 3.8 nM) and 9.0% oral bioavailability (BA), used in COVID-19 research [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | 8-10 weeks | |
| 50 mg | $1,980 | 8-10 weeks | |
| 100 mg | $2,500 | 8-10 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | SARS-CoV-2 3CLpro-IN-5 is a covalent inhibitor targeting the 3C-like protease (3CLpro), with potent inhibitory activity (IC50: 3.8 nM) and 9.0% oral bioavailability (BA), used in COVID-19 research [1]. |
| In vitro | SARS-CoV-2 3CLpro-IN-5 demonstrates inhibitory activity against 3CL protease with an IC50 of 3.8 nM [1], and antiviral effects against SARS-CoV-2 variants (Alpha, Delta, Omicron BA.1, BA.2) in 293TAT cells, with EC50 values of 13.8 nM, 7.57 nM, 9.01 nM, and 17.1 nM, respectively [1]. It also shows activity against other coronaviruses: SARS-CoV (EC50 59.3 nM), MERS-CoV in 293TDPP4 cells (EC50 4.72 nM), and HCoV-OC43 (EC50 1.67 nM) [1]. |
| In vivo | SARS-CoV-2 3CLpro-IN-5, when administered orally or intravenously at dosages of 10 or 100 mg/kg, exhibits potent antiviral effects and possesses advantageous pharmacokinetic properties [1]. |
| Molecular Weight | 497.92 |
| Formula | C22H26ClF2N5O4 |
| Cas No. | 2913186-57-7 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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