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K-Ras G12C-IN-3

Name: K-Ras G12C-IN-3
Brand: TargetMol
SKU: T11737
Rating: 4.5 (1 reviews)

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Catalog No. T11737Cas No. 1629268-19-4

Heterocyclic compounds as covalent inhibitors of G12C mutant K-Ras protein useful for treating cancers.K-Ras G12C-IN-3 is a novel and irreversible inhibitor of mutant K-ras G12C.

K-Ras G12C-IN-3

😃Good

Catalog No. T11737Cas No. 1629268-19-4

Heterocyclic compounds as covalent inhibitors of G12C mutant K-Ras protein useful for treating cancers.K-Ras G12C-IN-3 is a novel and irreversible inhibitor of mutant K-ras G12C.

Pack Size	Price	Availability
5 mg	$347	6-8 weeks
25 mg	$1,140	6-8 weeks
50 mg	$1,490	6-8 weeks
100 mg	$1,990	6-8 weeks
1 mL x 10 mM (in DMSO)	$346	6-8 weeks

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Product Introduction

Bioactivity

Description

Heterocyclic compounds as covalent inhibitors of G12C mutant K-Ras protein useful for treating cancers.K-Ras G12C-IN-3 is a novel and irreversible inhibitor of mutant K-ras G12C.

Chemical Properties

Molecular Weight	453.75
Formula	C₂₁H₁₉Cl₃N₂O₃
Cas No.	1629268-19-4
Relative Density.	1.360 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 30 mg/mL (66.12 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2039 mL	11.0193 mL	22.0386 mL	110.1928 mL
5 mM	0.4408 mL	2.2039 mL	4.4077 mL	22.0386 mL
10 mM	0.2204 mL	1.1019 mL	2.2039 mL	11.0193 mL
20 mM	0.1102 mL	0.5510 mL	1.1019 mL	5.5096 mL
50 mM	0.0441 mL	0.2204 mL	0.4408 mL	2.2039 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

KRas G12CIN3K-Ras G12C-IN-3K Ras G12C IN 3K-Ras G-12C-IN-3