Shopping Cart
- Remove All
![TargetMol](https://www.targetmol.com/storage/error/oops.webp)
Your shopping cart is currently empty
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $35 | In Stock | |
5 mg | $113 | In Stock | |
10 mg | $179 | In Stock | |
25 mg | $313 | In Stock | |
50 mg | $479 | In Stock | |
100 mg | $687 | In Stock | |
1 mL x 10 mM (in DMSO) | $126 | In Stock |
Description | JCN037 is potent, non-covalent and brain-penetrant inhibitor of EGFR(EGFR, p-wtEGFR and pEGFRvⅢ with IC50 of 2.49 nM, 3.95 nM, 4.48 nM , respectively). |
Targets&IC50 | p-EGFR VⅢ:4.48 nM , p-EGFR (WT):3.95 nM , EGFR:2.49 nM |
In vivo | Relative to the conventional EGFR TKIs erlotinib and lapatinib, JCN037 displayed potent activity against EGFR amplified/mutant patient-derived cell cultures, significant BBB penetration (2:1 brain-to-plasma ratio), and superior efficacy in an EGFR-driven orthotopic glioblastoma xenograft model. |
Molecular Weight | 376.18 |
Formula | C16H11BrFN3O2 |
Cas No. | 2305154-31-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
Solubility Information | DMSO: 10 mg/mL (26.58 mM) ![]() | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
|
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.