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BSH-IN-1

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Purity:98%

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COA HNMR HPLC

BSH-IN-1

Catalog No. T10623Cas No. 2553217-91-5

BSH-IN-1 is a potent and covalent inhibitor of gut bacterial recombinant bile salt hydrolases (BSHs; IC50s: 108 nM and 427 nM for B. longum BSH and B. theta BSH).

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Pack Size	Price	Availability
1 mg	$158	In Stock
5 mg	$397	In Stock
10 mg	$589	In Stock
25 mg	$945	In Stock
50 mg	$1,280	In Stock
100 mg	$1,730	In Stock
1 mL x 10 mM (in DMSO)	$437	In Stock

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Product Introduction

Bioactivity

Description	BSH-IN-1 is a potent and covalent inhibitor of gut bacterial recombinant bile salt hydrolases (BSHs; IC50s: 108 nM and 427 nM for B. longum BSH and B. theta BSH).
In vitro	BSH-IN-1 also inhibits BSH activity in growing cultures of Gram-negative (Bacteroides fragilis ATCC 25285, B. theta VPI-5482, and Bacteroides vulgatus ATCC 8482) and Gram-positive (C. perfringens ATCC 13124, Lactobacillus plantarum WCFS1, and Bifidobacterium adolescentis L2–32) bacteria. BSH-IN-1 also is a potent BSH inhibitor in growing bacterial cultures with IC50s of 237 nM and 1070 nM for B. adolescentis and B. theta, respectively.
In vivo	In C57BL/6 mice, BSH-IN-1 (10 mg/kg; a single dose; gavage）inhibits BSH activity and can be gut-restricted.

Chemical Properties

Molecular Weight	408.59
Formula	C25H41FO3
Cas No.	2553217-91-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 40 mg/mL (97.9 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4474 mL	12.2372 mL	24.4744 mL	122.3721 mL
5 mM	0.4895 mL	2.4474 mL	4.8949 mL	24.4744 mL
10 mM	0.2447 mL	1.2237 mL	2.4474 mL	12.2372 mL
20 mM	0.1224 mL	0.6119 mL	1.2237 mL	6.1186 mL
50 mM	0.0489 mL	0.2447 mL	0.4895 mL	2.4474 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc