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Tannic acid (Gallotannic acid) is a novel hERG channel blocker.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
500 mg | $41 | In Stock |
Description | Tannic acid (Gallotannic acid) is a novel hERG channel blocker. |
Targets&IC50 | ERG channel (human):3.4 μM |
In vitro | METHODS: Rat cardiomyocytes H9C2 were treated with Tannic acid (5-50 µM) for 24 h. Cell viability was determined by CCK-8 Assay. RESULTS: Treatment of H9C2 cells with Tannic acid concentration ≥ 30 µM resulted in a significant decrease in cell viability. [1] METHODS: Human lung cancer cells A549 were treated with Tannic acid (20-60 µM) for 24-48 h. Cell cycle was measured by Flow cytometry. RESULTS: Tannic acid inhibited cell viability in a dose-dependent manner at 24 h, with higher inhibition after 48 h. The IC50 values for Tannic acid were estimated to be in the range of 40-60 µM at 24 h and 20-40 µM at 48 h. [1] METHODS: Human lung cancer cells A549 were treated with Tannic acid (20-60 µM) for 24-48 h. Cell cycle was measured by Flow cytometry. [2] |
In vivo | METHODS: To investigate the effects on oxidative stress mice, Tannic acid (2.5-10 mg/kg) was administered orally to diquat-induced oxidative stress C57BL/6J mouse model once daily for ten days. RESULTS: Tannic acid pretreatment in the oxidative stress mouse model failed to alter antioxidant enzymes but modulated jejunal morphology, colon length, antioxidant pathways, and intestinal barrier in the diquat oxidative model. [3] |
Alias | Gallotannic acid |
Cas No. | 1401-55-4 |
Relative Density. | 2.12 g/cm3 |
Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO: 25 mg/mL (14.7 mM), Sonication is recommended. H2O: 17.24 mg/mL (10.13 mM), Sonication is recommended. |
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