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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $153 | In Stock | |
5 mg | $392 | In Stock | |
10 mg | $583 | In Stock | |
25 mg | $937 | In Stock | |
50 mg | $1,270 | In Stock | |
100 mg | $1,720 | In Stock | |
500 mg | $3,430 | In Stock | |
1 mL x 10 mM (in DMSO) | $375 | In Stock |
Description | ARS-853 is an inhibitor of K-RASG12C(IC50 : 2.5 μM), a mutant form of K-RAS that accumulates in the active GTP-bound state in certain cancer cells |
In vitro | ARS-853 decreases phosphorylation of c-RAF, ERK, and Akt. ARS853 inhibits proliferation of six lung cancer cell lines containing the K-RASG12C mutation, including H358 cells (IC50 = 2.5 μM), but does not inhibit proliferation of PC-9 cells, which contain wild-type K-RAS[1]. |
Molecular Weight | 432.94 |
Formula | C22H29ClN4O3 |
Cas No. | 1629268-00-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||
Solubility Information | DMSO: 5.5 mg/mL (12.7 mM) ![]() | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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