Shopping Cart

Remove All

Your shopping cart is currently empty

BBDDL2059

Catalog No. T79200Cas No. 2691174-27-1

BBDDL2059 is a selective covalent inhibitor targeting EZH2, exhibiting an IC50 of 1.5 nM against the EZH2-Y641F mutant. It demonstrates potency in inhibiting lymphoma cell proliferation at nanomolar concentrations, proving its utility in anticancer research [1].

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
25 mg	$1,670	8-10 weeks
50 mg	$2,180	8-10 weeks
100 mg	$2,800	8-10 weeks

Bulk & Custom

Add to Cart

Questions

Product Introduction

Bioactivity

Description	BBDDL2059 is a selective covalent inhibitor targeting EZH2, exhibiting an IC50 of 1.5 nM against the EZH2-Y641F mutant. It demonstrates potency in inhibiting lymphoma cell proliferation at nanomolar concentrations, proving its utility in anticancer research [1].
In vitro	BBDDL2059 (Compound 16) at concentrations ranging from 0-65 nM over 6 days inhibits the growth of KARPAS-422 and Pfeiffer cells [1]. Moreover, BBDDL2059 at doses between 0-1 µM for 48-96 hours suppresses EZH2 enzymatic activity and sustains long-term inhibition of EZH2 following washout [1].
In vivo	BBDDL2059 (Compound 16) demonstrated a pharmacokinetic profile in rats, with a half-life (T 1/2) of 0.28 hours following an intravenous dose of 3 mg/kg and an oral bioavailability (F%) of 0.05% at a 10 mg/kg oral dose [1]. The respective pharmacokinetic parameters for intravenous administration were a maximum concentration (Cmax) of 4886 ng/mL, an area under the curve (AUC0-last) of 11.1 h•ng/mL, a clearance (CL) of 161 mL•min^-1/kg^-1, and a steady-state volume of distribution (Vss) of 11.1 L/kg. The oral dose resulted in a Cmax of 29.5 ng/mL and an AUC0-last of 8.16 h•ng/mL [1].

Chemical Properties

Molecular Weight	512.66
Formula	C27H36N4O4S
Cas No.	2691174-27-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc