Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

BBDDL2059

😃Good
Catalog No. T79200Cas No. 2691174-27-1

BBDDL2059 is a selective covalent inhibitor of EZH2 with an IC50 of 1.5 nM against the EZH2-Y641F mutant, demonstrating nanomolar potency in inhibiting lymphoma cell proliferation, thereby proving its utility in anticancer research [1].

BBDDL2059

BBDDL2059

😃Good
Catalog No. T79200Cas No. 2691174-27-1
BBDDL2059 is a selective covalent inhibitor of EZH2 with an IC50 of 1.5 nM against the EZH2-Y641F mutant, demonstrating nanomolar potency in inhibiting lymphoma cell proliferation, thereby proving its utility in anticancer research [1].
Pack SizePriceAvailabilityQuantity
25 mg$1,6708-10 weeks
50 mg$2,1808-10 weeks
100 mg$2,8008-10 weeks
Bulk & Custom
Add to Cart
Questions
View More
Contact us for more batch information
Resource Download
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity
Description
BBDDL2059 is a selective covalent inhibitor of EZH2 with an IC50 of 1.5 nM against the EZH2-Y641F mutant, demonstrating nanomolar potency in inhibiting lymphoma cell proliferation, thereby proving its utility in anticancer research [1].
Targets&IC50
EZH2 (Y641F):1.5 nM
In vitro
BBDDL2059 (Compound 16) at concentrations ranging from 0-65 nM over 6 days inhibits the growth of KARPAS-422 and Pfeiffer cells [1]. Moreover, BBDDL2059 at doses between 0-1 µM for 48-96 hours suppresses EZH2 enzymatic activity and sustains long-term inhibition of EZH2 following washout [1].
In vivo
BBDDL2059 (Compound 16) demonstrated a pharmacokinetic profile in rats, with a half-life (T 1/2) of 0.28 hours following an intravenous dose of 3 mg/kg and an oral bioavailability (F%) of 0.05% at a 10 mg/kg oral dose [1]. The respective pharmacokinetic parameters for intravenous administration were a maximum concentration (Cmax) of 4886 ng/mL, an area under the curve (AUC0-last) of 11.1 h•ng/mL, a clearance (CL) of 161 mL•min^-1/kg^-1, and a steady-state volume of distribution (Vss) of 11.1 L/kg. The oral dose resulted in a Cmax of 29.5 ng/mL and an AUC0-last of 8.16 h•ng/mL [1].
Chemical Properties
Molecular Weight512.66
FormulaC27H36N4O4S
Cas No.2691174-27-1
Storage & Solubility Information
StorageShipping with blue ice.

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
%Tween 80
%ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Related Tags: buy BBDDL2059 | purchase BBDDL2059 | BBDDL2059 cost | order BBDDL2059 | BBDDL2059 chemical structure | BBDDL2059 in vivo | BBDDL2059 in vitro | BBDDL2059 formula | BBDDL2059 molecular weight