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SJG-136

Name: SJG-136
Brand: TargetMol
SKU: T16890
Price: 80 EUR
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T16890Cas No. 232931-57-6

Alias NSC-694501

SJG-136, a DNA cross-linking agent (XL50: 45 nM for pBR322 DNA), is used for its capability to form covalent bonds between DNA strands.

SJG-136

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Catalog No. T16890Alias NSC-694501Cas No. 232931-57-6

SJG-136, a DNA cross-linking agent (XL50: 45 nM for pBR322 DNA), is used for its capability to form covalent bonds between DNA strands.

Pack Size	Price	Availability
25 mg	$1,500	10-14 weeks
50 mg	$1,950	10-14 weeks
100 mg	$2,950	10-14 weeks

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Product Introduction

Bioactivity

Description	SJG-136, a DNA cross-linking agent (XL50: 45 nM for pBR322 DNA), is used for its capability to form covalent bonds between DNA strands.
Targets&IC50	pBR322 DNA:（XL50）45 nM
In vitro	SJG-136 is cytotoxic to ovarian cell lines, such as A2780 (IC50: 22.5 pM), A2780cisR (IC50: 24 pM), CH1 (IC50: 0.12 nM), CH1cisR (IC50: 0.6 nM), and SKOV-3 (IC50: 9.1 nM). SJG-136 also reduces the viability of a panel of canine cancer cells (GI50: ranging from 0.33 - >100 nM after a 1 h exposure, and <0.03 - 17.33 nM following continuous exposure) [1][2].
In vivo	SJG-136-induced H2AX phosphorylation correlates well, albeit with lower sensitivity, compared to foci measurement. At a dosage of 0.30 mg/kg, SJG-136 exhibits a stronger antitumor effect on CMeC-1 tumors in mice than at 0.15 mg/kg, regardless of whether it is given as a single dose or once weekly for three weeks through intravenous administration [2].
Alias	NSC-694501

Chemical Properties

Molecular Weight	556.61
Formula	C₃₁H₃₂N₄O₆
Cas No.	232931-57-6
Relative Density.	1.36g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 100 mg/mL (179.66 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7966 mL	8.9830 mL	17.9659 mL	89.8295 mL
5 mM	0.3593 mL	1.7966 mL	3.5932 mL	17.9659 mL
10 mM	0.1797 mL	0.8983 mL	1.7966 mL	8.9830 mL
20 mM	0.0898 mL	0.4491 mL	0.8983 mL	4.4915 mL
50 mM	0.0359 mL	0.1797 mL	0.3593 mL	1.7966 mL
100 mM	0.0180 mL	0.0898 mL	0.1797 mL	0.8983 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc