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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $38 | In Stock | |
10 mg | $58 | In Stock | |
25 mg | $127 | In Stock | |
50 mg | $229 | In Stock | |
100 mg | $297 | In Stock | |
500 mg | $728 | In Stock | |
1 mL x 10 mM (in DMSO) | $50 | In Stock |
Description | Zebularine (4-Deoxyuridine) is a DNA methylation inhibitor. Acts as a transition state analog inhibitor of cytidine deaminase by binding to the active size as covalent hydrates. It also inhibits cytidine deaminase (Ki: 2 μM, in a cell-free assay). |
Cell Research | For methylation analysis, 10T1/2 cells and T24 cells are treated with the various concentrations of zebularine. For 10T1/2 cells, the medium is changed 24 hours after the initial drug treatment, whereas for T24 cells, the medium is changed 24 hours or 48 hours after the initial drug treatment. DNA and RNA are harvested from 10T1/2 cells 72 hours after initial drug treatment and from T24 cells 96 hours after initial drug treatment. The methylation status of the indicated DNA regions is measured in two separate and independent experiments, both of which are done in duplicate[2]. |
Alias | NSC309132, 4-Deoxyuridine |
Molecular Weight | 228.2 |
Formula | C9H12N2O5 |
Cas No. | 3690-10-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 60 mg/mL (262.93 mM) ![]() H2O: 22.8 mg/mL (100 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO/H2O
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