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Zebularine
🥰Excellent
Catalog No. T2169Cas No. 3690-10-6
Alias NSC309132, 4-Deoxyuridine
Zebularine (4-Deoxyuridine) is a DNA methylation inhibitor. Acts as a transition state analog inhibitor of cytidine deaminase by binding to the active size as covalent hydrates. It also inhibits cytidine deaminase (Ki: 2 μM, in a cell-free assay).
Zebularine
🥰Excellent
Purity: 100%
Catalog No. T2169Alias NSC309132, 4-DeoxyuridineCas No. 3690-10-6
Zebularine (4-Deoxyuridine) is a DNA methylation inhibitor. Acts as a transition state analog inhibitor of cytidine deaminase by binding to the active size as covalent hydrates. It also inhibits cytidine deaminase (Ki: 2 μM, in a cell-free assay).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $38 | In Stock | |
| 10 mg | $58 | In Stock | |
| 25 mg | $127 | In Stock | |
| 50 mg | $229 | In Stock | |
| 100 mg | $297 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $43 | In Stock |
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Purity:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Zebularine (4-Deoxyuridine) is a DNA methylation inhibitor. Acts as a transition state analog inhibitor of cytidine deaminase by binding to the active size as covalent hydrates. It also inhibits cytidine deaminase (Ki: 2 μM, in a cell-free assay). |
| Targets&IC50 | Cytidine deaminase:2 μM(Ki) |
| In vitro | Zebularine forms a tight covalent complex with bacterial methyltransferases. In N. crassa, Zebularine inhibited DNA methylation and reactivated genes silenced by methylation. In T24 bladder cancer cells, Zebularine reactivated the silenced p16 gene and demethylated its promoter region.Zebularine was only slightly cytotoxic to T24 cells. Zebularine was preferentially incorporated into the DNA of cancer cell lines and inhibited cell growth and gene expression to a greater extent than in normal fibroblasts. In addition, Zebularine preferentially inhibited DNA methyltransferase 1 and induced the expression of cancer-associated antigenic genes in cancer cells compared to normal fibroblasts. |
| In vivo | Zebularine forms a tight covalent complex with bacterial methyltransferases. In N. crassa, Zebularine inhibited DNA methylation and reactivated genes silenced by methylation. In T24 bladder cancer cells, Zebularine reactivated the silenced p16 gene and demethylated its promoter region.Zebularine was only slightly cytotoxic to T24 cells. Zebularine was preferentially incorporated into the DNA of cancer cell lines and inhibited cell growth and gene expression to a greater extent than in normal fibroblasts. In addition, Zebularine preferentially inhibited DNA methyltransferase 1 and induced the expression of cancer-associated antigenic genes in cancer cells compared to normal fibroblasts. |
| Cell Research | For methylation analysis, 10T1/2 cells and T24 cells are treated with the various concentrations of zebularine. For 10T1/2 cells, the medium is changed 24 hours after the initial drug treatment, whereas for T24 cells, the medium is changed 24 hours or 48 hours after the initial drug treatment. DNA and RNA are harvested from 10T1/2 cells 72 hours after initial drug treatment and from T24 cells 96 hours after initial drug treatment. The methylation status of the indicated DNA regions is measured in two separate and independent experiments, both of which are done in duplicate[2]. |
| Alias | NSC309132, 4-Deoxyuridine |
| Molecular Weight | 228.2 |
| Formula | C9H12N2O5 |
| Cas No. | 3690-10-6 |
| Smiles | OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cccnc1=O |
| Relative Density. | 1.73 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 60 mg/mL (262.93 mM)  H2O: 22.8 mg/mL (100 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O/DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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