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Xylitol (Ribitol) is a five-carbon sugar alcohol derived from XYLOSE by reduction of the carbonyl group. It is as sweet as sucrose and used as a noncariogenic sweetener.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 g | $48 | In Stock | |
10 g | $70 | In Stock |
Description | Xylitol (Ribitol) is a five-carbon sugar alcohol derived from XYLOSE by reduction of the carbonyl group. It is as sweet as sucrose and used as a noncariogenic sweetener. |
In vitro | Xylitol is reported to have an inhibitory effect on LPS-induced inflammatory cytokine expression[2]. Xylitol strongly inhibits tube formation, migration, and invasion of HUVECs. Xylitol decreases the mRNA expression of key angiogenic molecules and their receptors (VEGF, KDR, bFGF and bFGFR-II) in a dose-dependent manner. Also, it suppresses NF-κB and Akt activation of HUVECs[1]. |
In vivo | Xylitol triggers the release of insulin in dogs[3] and inhibits in vivo angiogenesis. It prominently inhibits the formation of neo-microvessels in the Matrigel assay, and reduces the hemoglobin content in the Matrigel plug[1]. |
Cell Research | In vitro tube formation assay:HUVECs (2×104 cells) are seeded on a layer of previously polymerized Matrigel and treated with or without xylitol. Matrigel culture is incubated at 37°C. After 6 h, changes in cell morphology are captured through a phase contrast microscope and photographed at ×40 magnification. Each sample is assayed in duplicate and independent experiments are repeated three times. (Only for Reference) |
Alias | Xylite, Ribitol, D-Xylitol, Adonitol, Adonite |
Molecular Weight | 152.15 |
Formula | C5H12O5 |
Cas No. | 87-99-0 |
Smiles | C(C(CO)O)(C(CO)O)O |
Relative Density. | 1.52. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | H2O: 197.2 mM DMSO: 45 mg/mL (295.76 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O/DMSO
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