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Ribitol

🥰Excellent
Catalog No. T6640Cas No. 488-81-3
Alias Adonitol, Adonite

Ribitol is a pentitol that can be formed by ribose reduction. Enhancement of the D-glucose to pentose phosphate pathway in Saccharomyces cerevisiae can be used to produce ribitol and D-ribose.

Ribitol

Ribitol

🥰Excellent
Purity: 99.85%
Catalog No. T6640Alias Adonitol, AdoniteCas No. 488-81-3
Ribitol is a pentitol that can be formed by ribose reduction. Enhancement of the D-glucose to pentose phosphate pathway in Saccharomyces cerevisiae can be used to produce ribitol and D-ribose.
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500 mg$30In Stock
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Purity:99.85%
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Product Introduction

Bioactivity
Description
Ribitol is a pentitol that can be formed by ribose reduction. Enhancement of the D-glucose to pentose phosphate pathway in Saccharomyces cerevisiae can be used to produce ribitol and D-ribose.
In vitro
Ribitol is a crystalline pentose alcohol. [1] Ribitol is characterized from the plant Adonis vernalis. [2] Ribitol in 10% NFSM suspending medium exerts 1.45 to 2.18 times the protective effect exerted by glycerol at equal concentration. The cryoprotective action of Ribitol reaches its highest level at 0.75 M. For 11 of the 13 organisms tested including S. lactis T164, the degree of protection conferred by Ribitol is >80%. Ribitol has a strong protective effect on lactic acid bacteria during freeze-drying. [3]
Kinase Assay
The high-performance liquid chromatography (HPLC) analyses are carried out using a Fast Acid Column (100×7.8 mm) and a HPX-87H Ion Exclusion Column (300 mm×7.8 mm) in series with 2.5 mM H2SO4 in water as the mobile phase at a flow rate of 0.3 mL/min, at 55°C. This method enabled quantification of D-glucose, ethanol, glycerol, D-xylulose, Ribitol, and xylitol. D-ribose, D-ribulose, and D-arabitol coeluted on the Aminex HPX-87H column. The CarboPac MA-1 column of Dionex ICS-3000 is used to analyze representative culture supernatant samples for the presence of arabitol and xylitol. Samples are run at column temperature of 30°C with 480 mM NaOH at flow rate 0.4 mL/min. The CarboPac MA-1 column separated D-arabitol from D-ribose and D-ribulose, but the alkaline conditions degraded D-ribulose interfering with the quantification of D-ribose.Yeast cells are disrupted with glass beads in 100 mM sodium phosphate buffer pH 7.0 containing phenylmethylsulfonyl fluoride and pepstatin A in final concentrations of 0.17 mg/mL and 0.01 mg/mL, respectively.The activity of NAD+-dependent Gdh2p is measured in a reaction buffer of 0.5 M triethanol amine pH 7.7 and 2 mM NADH. After addition of the cell lysate, the reaction is started by adding a mixture of α-ketoglutarate (100 mM) and NH4Cl (200 mM) to a final concentration of 2.4 mM and 4.9 mM, respectively. The GapB activity is measured. Shortly, the reaction mixture is 500 mM triethanol amine pH 7.8, 1 mM ATP, 2 mM MgCl2, 200 μM NADPH, and 10 μg/mL of phosphoglycerate kinase. 3-phosphoglycerate is added to a final concentration of 5 mM to start the reaction. Activity measurements are performed with a Cobas Mira Plus automated analyzer[2].
AliasAdonitol, Adonite
Chemical Properties
Molecular Weight152.15
FormulaC5H12O5
Cas No.488-81-3
SmilesC(C(CO)O)(C(CO)O)O
Relative Density.1.1497 g/cm3 (Estimated)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 6.2 mg/mL (40.75 mM), Sonication is recommended.
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM6.5725 mL32.8623 mL65.7246 mL328.6231 mL
5 mM1.3145 mL6.5725 mL13.1449 mL65.7246 mL
10 mM0.6572 mL3.2862 mL6.5725 mL32.8623 mL
20 mM0.3286 mL1.6431 mL3.2862 mL16.4312 mL

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