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(R)-Pirtobrutinib

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Catalog No. T35844Cas No. 2101700-14-3

(R)-Pirtobrutinib ((R)-LOXO-305) is the less active enantiomer of Pirtobrutinib, a highly selective, non-covalent, next-generation BTK inhibitor that effectively inhibits diverse BTK C481 substitution mutations [1].

(R)-Pirtobrutinib
Other Forms of (R)-Pirtobrutinib:
PirtobrutinibT362872101700-15-4
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(R)-Pirtobrutinib

🥰Excellent
Catalog No. T35844Cas No. 2101700-14-3
(R)-Pirtobrutinib ((R)-LOXO-305) is the less active enantiomer of Pirtobrutinib, a highly selective, non-covalent, next-generation BTK inhibitor that effectively inhibits diverse BTK C481 substitution mutations [1].
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Product Introduction

Bioactivity
Description
(R)-Pirtobrutinib ((R)-LOXO-305) is the less active enantiomer of Pirtobrutinib, a highly selective, non-covalent, next-generation BTK inhibitor that effectively inhibits diverse BTK C481 substitution mutations [1].
Chemical Properties
Molecular Weight479.436
FormulaC22H21F4N5O3
Cas No.2101700-14-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 200 mg/mL (417.16 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.0858 mL10.4289 mL20.8578 mL104.2892 mL
5 mM0.4172 mL2.0858 mL4.1716 mL20.8578 mL
10 mM0.2086 mL1.0429 mL2.0858 mL10.4289 mL
20 mM0.1043 mL0.5214 mL1.0429 mL5.2145 mL
50 mM0.0417 mL0.2086 mL0.4172 mL2.0858 mL
100 mM0.0209 mL0.1043 mL0.2086 mL1.0429 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

(R)PirtobrutinibPirtobrutinib(R) Pirtobrutinib
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