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Pirtobrutinib

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Purity:99.89%

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COA HNMR HPLC

Pirtobrutinib

Catalog No. T36287Cas No. 2101700-15-4

Pirtobrutinib (LOXO-305) is an advanced BTK inhibitor that displays high selectivity and operates through a non-covalent mechanism. This compound effectively inhibits various BTK C481 substitution mutations, leading to tumor regression in BTK-dependent lymphoma tumors in mouse xenograft models. Furthermore, Pirtobrutinib exhibits remarkable selectivity for BTK, with more than a 300-fold difference compared to 370 other kinases tested. Notably, at a concentration of 1 μM, Pirtobrutinib demonstrates no significant inhibition of non-kinase off-targets.

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Pack Size	Price	Availability
1 mg	$31	In Stock
5 mg	$72	In Stock
10 mg	$128	In Stock
25 mg	$297	In Stock
50 mg	$457	In Stock
100 mg	$672	In Stock
500 mg	$1,430	In Stock
1 mL x 10 mM (in DMSO)	$76	In Stock

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Product Introduction

Bioactivity

Description

In vitro

Pirtobrutinib potently inhibits both wild-type BTK and BTK C481S-mediated kinase activity with nanomolar potency. Pirtobrutinib strongly inhibits WT BTK (Y223) autophosphorylation with an IC50 of 3.68 nM. Pirtobrutinib inhibits BTK C481S Y223, C481T Y223, and C481R Y223 autophosphorylation with IC50s of 8.45, 7.23, and 11.73 nM, respectively[1].

Chemical Properties

Molecular Weight	479.43
Formula	C22H21F4N5O3
Cas No.	2101700-15-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (114.72 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0858 mL	10.4291 mL	20.8581 mL	104.2905 mL
5 mM	0.4172 mL	2.0858 mL	4.1716 mL	20.8581 mL
10 mM	0.2086 mL	1.0429 mL	2.0858 mL	10.4291 mL
20 mM	0.1043 mL	0.5215 mL	1.0429 mL	5.2145 mL
50 mM	0.0417 mL	0.2086 mL	0.4172 mL	2.0858 mL
100 mM	0.0209 mL	0.1043 mL	0.2086 mL	1.0429 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc