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CP-547632

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Purity:98.51%

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COA FNMR LCMS HNMR

CP-547632

Catalog No. T10870LCas No. 252003-65-9

CP-547632 is an orally available and potent, ATP-competitive dual inhibitor of VEGFR-2 and FGF kinase F with IC50s of 11 nM and 9 nM, respectively. CP-547632 is selective, with higher selectivity for VEGFR2 and bFGF than for EGFR, PDGFRβ and related tyrosine kinases (TKs). PDGFRβ and related tyrosine kinases (TKs) CP-547632 has antitumour activity.

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Pack Size	Price	Availability
1 mg	$30	In Stock
2 mg	$43	In Stock
5 mg	$68	In Stock
10 mg	$98	In Stock
25 mg	$179	In Stock
50 mg	$255	In Stock
1 mL x 10 mM (in DMSO)	$81	In Stock

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Product Introduction

Bioactivity

Description	CP-547632 is an orally available and potent, ATP-competitive dual inhibitor of VEGFR-2 and FGF kinase F with IC50s of 11 nM and 9 nM, respectively. CP-547632 is selective, with higher selectivity for VEGFR2 and bFGF than for EGFR, PDGFRβ and related tyrosine kinases (TKs). PDGFRβ and related tyrosine kinases (TKs) CP-547632 has antitumour activity.
Targets&IC50	VEGFR2:11 nM, FGFR:9 nM
In vitro	CP-547632 (1-1000 nM ; 1 h) suppresses VEGF-induced VEGFR-2 phosphorylation in a concentration-dependent manner (IC50: 6 nM). [1]
In vivo	CP-547632 (oral ; 50 mg/kg) yieldes plasma concentrations above 500 ng/ml for 12 hours. CP-547632 (p.o. ; 6.25-100 mg/kg/day ; for 10-24 days) causes a dose-dependent inhibition of growth in Colo-205, DLD-1, and MDA-MB-231 xenografts.[1]

Chemical Properties

Molecular Weight	532.4
Formula	C20H24BrF2N5O3S
Cas No.	252003-65-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 90.0 mg/mL (169.0 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8783 mL	9.3914 mL	18.7829 mL	93.9144 mL
5 mM	0.3757 mL	1.8783 mL	3.7566 mL	18.7829 mL
10 mM	0.1878 mL	0.9391 mL	1.8783 mL	9.3914 mL
20 mM	0.0939 mL	0.4696 mL	0.9391 mL	4.6957 mL
50 mM	0.0376 mL	0.1878 mL	0.3757 mL	1.8783 mL
100 mM	0.0188 mL	0.0939 mL	0.1878 mL	0.9391 mL

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