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CP-547632 hydrochloride

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Catalog No. T10870Cas No. 252003-71-7

CP-547632 hydrochloride is a well-tolerated and orally-bioavailable inhibitor of the VEGFR-2 and basic FGF kinases (IC50s: 11 nM and 9 nM) with antitumor efficacy.

CP-547632 hydrochloride

CP-547632 hydrochloride

😃Good
Catalog No. T10870Cas No. 252003-71-7
CP-547632 hydrochloride is a well-tolerated and orally-bioavailable inhibitor of the VEGFR-2 and basic FGF kinases (IC50s: 11 nM and 9 nM) with antitumor efficacy.
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2 mg$445 days
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Product Introduction

Bioactivity
Description
CP-547632 hydrochloride is a well-tolerated and orally-bioavailable inhibitor of the VEGFR-2 and basic FGF kinases (IC50s: 11 nM and 9 nM) with antitumor efficacy.
Targets&IC50
VEGFR2:11 nM, FGFR:9 nM
In vitro
CP-547632 hydrochloride (1–1000 nM; 1 hour) inhibits VEGF-stimulated VEGFR-2 phosphorylation in a dose-dependent manner (IC50: 6 nM).
In vivo
In DLD-1, Colo-205, and MDA-MB-231 xenografts, CP-547632 hydrochloride (p.o.; 6.25-100 mg/kg/day; for 10-24 days) causes a dose-dependent inhibition of growth. CP-547632 hydrochloride (oral; 50 mg/kg) yields plasma concentrations above 500 ng/ml for 12 hours.
Chemical Properties
Molecular Weight568.86
FormulaC20H25BrClF2N5O3S
Cas No.252003-71-7
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 38.33 mg/mL (67.38 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.7579 mL8.7895 mL17.5790 mL87.8951 mL
5 mM0.3516 mL1.7579 mL3.5158 mL17.5790 mL
10 mM0.1758 mL0.8790 mL1.7579 mL8.7895 mL
20 mM0.0879 mL0.4395 mL0.8790 mL4.3948 mL
50 mM0.0352 mL0.1758 mL0.3516 mL1.7579 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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