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KSC-34

Name: KSC-34
Brand: TargetMol
SKU: T39704
Price: 149 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T39704Cas No. 2226201-97-2

KSC-34 is a covalent modifier of protein disulfide isomerase A1 (PDIA1).KSC-34 is a selective inhibitor targeting the a-site of PDIA1.It inhibits PDIA1 reductase activity in a time-dependent manner and is used to study diseases caused by abnormalities in amyloid.128-63-63-5

KSC-34

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Purity: 98%

Catalog No. T39704Cas No. 2226201-97-2

Pack Size	Price	Availability	Quantity
1 mg	$149	In Stock

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Purity:98%

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COA HNMR LCMS

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Product Introduction

Bioactivity

Description	KSC-34 is a covalent modifier of protein disulfide isomerase A1 (PDIA1).KSC-34 is a selective inhibitor targeting the a-site of PDIA1.It inhibits PDIA1 reductase activity in a time-dependent manner and is used to study diseases caused by abnormalities in amyloid.128-63-63-5
Targets&IC50	PDIA1 (a domain):3.5 μM, PDIA1 (a' domain):104.5 μM
In vitro	KSC-34 displays time-dependent inhibition of PDIA1 reductase activity in vitro with a kinact/ KI of 9.66 × 103 M-1 s-1 and is selective for PDIA1 over other members of the PDI family, and other cellular cysteine-containing proteins[1].

Chemical Properties

Molecular Weight	429.95
Formula	C₂₁H₂₈ClN₇O
Cas No.	2226201-97-2
Smiles	O=C(NCCNC1=NC(=NC(=N1)N(C)CCCCC=2C=CC=CC2)NCC#C)CCl

Storage & Solubility Information

Storage

store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 80 mg/mL (186.07 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3259 mL	11.6293 mL	23.2585 mL	116.2926 mL
5 mM	0.4652 mL	2.3259 mL	4.6517 mL	23.2585 mL
10 mM	0.2326 mL	1.1629 mL	2.3259 mL	11.6293 mL
20 mM	0.1163 mL	0.5815 mL	1.1629 mL	5.8146 mL
50 mM	0.0465 mL	0.2326 mL	0.4652 mL	2.3259 mL
100 mM	0.0233 mL	0.1163 mL	0.2326 mL	1.1629 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

KSC34KSC 34KSC-34