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GSK-3β inhibitor 3

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Purity:97.53%

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COA HPLC HNMR

GSK-3β inhibitor 3

Catalog No. T35554Cas No. 1448990-73-5

GSK-3β inhibitor 3 is a covalent inhibitor (IC50: 6.6 μM) of glycogen synthase kinase 3β (GSK-3β) that is potent, selective, and irreversible.GSK-3β inhibitor 3 can be used to study acute promyelocytic leukemia.

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Pack Size	Price	Availability
1 mg	$98	In Stock
5 mg	$247	In Stock
10 mg	$393	In Stock
25 mg	$659	In Stock
50 mg	$939	In Stock
100 mg	$1,270	In Stock
500 mg	$2,550	In Stock
1 mL x 10 mM (in DMSO)	$272	In Stock

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Product Introduction

Bioactivity

Description	GSK-3β inhibitor 3 is a covalent inhibitor (IC50: 6.6 μM) of glycogen synthase kinase 3β (GSK-3β) that is potent, selective, and irreversible.GSK-3β inhibitor 3 can be used to study acute promyelocytic leukemia.
In vitro	GSK-3β inhibitor 3 (compound 4-3) (6.25-100 μM; 24-48 h) dose-dependently inhibited the cell viability, with IC50s of 19.56 μM and 26.42 μM in NB4 and NB4-R1 cells at 24 h, respectively. GSK-3β inhibitor 3 (12.5-100 μM; 24 h) significantly increases the percentage of apoptosis in a dose-dependent pattern in NB4 and NB4-R1 cells.[1] GSK-3β inhibitor 3 (100 μM) inhibits GSK-3α activity by 87.3%.[1]
In vivo	GSK-3β inhibitor 3 (compound 4-3) (15 mg/kg; a single i.p.; Balb/c female nude mice) shows T1/2 value 14.2 h, AUC values (AUClast=3503.42 ng/mL•h), and maximum concentration (Cmax=515 ng/mL) in mice.[1] GSK-3β inhibitor 3 (15 mg/kg/d; i.p. for 2 weeks; Balb/c female nude mice) inhibits tumor growth of mice by 75.97% relative to vehicle control.[1]

Chemical Properties

Molecular Weight	327.37
Formula	C18H14FNO2S
Cas No.	1448990-73-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 225.0 mg/mL (687.3 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0546 mL	15.2732 mL	30.5465 mL	152.7324 mL
5 mM	0.6109 mL	3.0546 mL	6.1093 mL	30.5465 mL
10 mM	0.3055 mL	1.5273 mL	3.0546 mL	15.2732 mL
20 mM	0.1527 mL	0.7637 mL	1.5273 mL	7.6366 mL
50 mM	0.0611 mL	0.3055 mL	0.6109 mL	3.0546 mL
100 mM	0.0305 mL	0.1527 mL	0.3055 mL	1.5273 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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