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GSK-3β inhibitor 3 is a potent, selective, and irreversible covalent inhibitor of glycogen synthase kinase 3β (GSK-3β) with an IC50 of 6.6 μM, and can be used to study acute promyelocytic leukemia.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $84 | In Stock | |
5 mg | $198 | In Stock | |
10 mg | $297 | In Stock | |
25 mg | $558 | In Stock | |
50 mg | $836 | In Stock | |
100 mg | $1,230 | In Stock | |
1 mL x 10 mM (in DMSO) | $226 | In Stock |
Description | GSK-3β inhibitor 3 is a potent, selective, and irreversible covalent inhibitor of glycogen synthase kinase 3β (GSK-3β) with an IC50 of 6.6 μM, and can be used to study acute promyelocytic leukemia. |
Targets&IC50 | GSK-3β:6.6 μM (IC50) |
In vitro | GSK-3β inhibitor 3 (compound 4-3) (6.25-100 μM; 24-48 h) dose-dependently inhibits cell viability, with IC50s of 19.56 μM and 26.42 μM in NB4 and NB4-R1 cells at 24 h, respectively. It (12.5-100 μM; 24 h) also significantly increases apoptosis in a dose-dependent manner in NB4 and NB4-R1 cells. Additionally, GSK-3β inhibitor 3 (100 μM) inhibits GSK-3α activity by 87.3%.[1] |
In vivo | GSK-3β inhibitor 3 (compound 4-3) (15 mg/kg; a single i.p.; Balb/c female nude mice) demonstrates a T1/2 of 14.2 hours, an AUClast of 3503.42 ng/mL•h, and a Cmax of 515 ng/mL in mice.[1] Additionally, GSK-3β inhibitor 3 (15 mg/kg/d; i.p. for 2 weeks; Balb/c female nude mice) inhibits tumor growth by 75.97% compared to the vehicle control.[1] |
Molecular Weight | 327.37 |
Formula | C18H14FNO2S |
Cas No. | 1448990-73-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 225.0 mg/mL (687.3 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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