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GSK-3β inhibitor 3

Catalog No. T35554Cas No. 1448990-73-5

GSK-3β inhibitor 3 is a potent, selective, and irreversible covalent inhibitor of glycogen synthase kinase 3β (GSK-3β) with an IC50 of 6.6 μM, and can be used to study acute promyelocytic leukemia.

GSK-3β inhibitor 3

GSK-3β inhibitor 3

Purity: 97.53%
Catalog No. T35554Cas No. 1448990-73-5
GSK-3β inhibitor 3 is a potent, selective, and irreversible covalent inhibitor of glycogen synthase kinase 3β (GSK-3β) with an IC50 of 6.6 μM, and can be used to study acute promyelocytic leukemia.
Pack SizePriceAvailabilityQuantity
1 mg$84In Stock
5 mg$198In Stock
10 mg$297In Stock
25 mg$558In Stock
50 mg$836In Stock
100 mg$1,230In Stock
1 mL x 10 mM (in DMSO)$226In Stock
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Purity:97.53%
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Product Introduction

Bioactivity
Description
GSK-3β inhibitor 3 is a potent, selective, and irreversible covalent inhibitor of glycogen synthase kinase 3β (GSK-3β) with an IC50 of 6.6 μM, and can be used to study acute promyelocytic leukemia.
Targets&IC50
GSK-3β:6.6 μM (IC50)
In vitro
GSK-3β inhibitor 3 (compound 4-3) (6.25-100 μM; 24-48 h) dose-dependently inhibits cell viability, with IC50s of 19.56 μM and 26.42 μM in NB4 and NB4-R1 cells at 24 h, respectively. It (12.5-100 μM; 24 h) also significantly increases apoptosis in a dose-dependent manner in NB4 and NB4-R1 cells. Additionally, GSK-3β inhibitor 3 (100 μM) inhibits GSK-3α activity by 87.3%.[1]
In vivo
GSK-3β inhibitor 3 (compound 4-3) (15 mg/kg; a single i.p.; Balb/c female nude mice) demonstrates a T1/2 of 14.2 hours, an AUClast of 3503.42 ng/mL•h, and a Cmax of 515 ng/mL in mice.[1] Additionally, GSK-3β inhibitor 3 (15 mg/kg/d; i.p. for 2 weeks; Balb/c female nude mice) inhibits tumor growth by 75.97% compared to the vehicle control.[1]
Chemical Properties
Molecular Weight327.37
FormulaC18H14FNO2S
Cas No.1448990-73-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 225.0 mg/mL (687.3 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.0546 mL15.2732 mL30.5465 mL152.7324 mL
5 mM0.6109 mL3.0546 mL6.1093 mL30.5465 mL
10 mM0.3055 mL1.5273 mL3.0546 mL15.2732 mL
20 mM0.1527 mL0.7637 mL1.5273 mL7.6366 mL
50 mM0.0611 mL0.3055 mL0.6109 mL3.0546 mL
100 mM0.0305 mL0.1527 mL0.3055 mL1.5273 mL

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