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PI3K-AKT-mTOR Compound Library

Catalog No. L1300
  Library Compound List   Excel SDF

The PI3K/AKT/mTOR pathway is an intracellular signaling pathway important in regulating the cell cycle. Therefore, it is directly related to cellular quiescence, proliferation, cancer, and longevity. Phosphatidylinositol 3-kinase (PI3K), AKT, a serine/threonine protein kinase also known as protein kinase B (PKB), and mammalian target of rapamycin (mTOR) are 3 major nodes in the pathway. PI3K activation phosphorylates and activates AKT, localizing it in the plasma membrane. AKT can have a number of downstream effects such as activating CREB, inhibiting p27, localizing FOXO in the cytoplasm, activating PtdIns-3ps, and activating mTOR which can affect transcription of p70 or 4EBP1. mTOR is a component of the PI3K/AKT cell survival pathway that monitors the availability of nutrients, mitogenic signals and cellular energy and oxygen levels, a major regulator of the autophagic process, and alterations in components of the mTOR pathway have a major role in tumor progression. Therefore, mTOR is an appealing therapeutic target in many tumors. Encouraging data from preclinical studies have offered new opportunities to fully exploit the therapeutic potential of mTOR targeting in cancer.

The PI3K/Akt/mTOR Compound Library by TargetMol, containing 425 compounds targeting PI3K/Akt/mTOR signaling, can be used for high throughput screening and high content screening for new drugs.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
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Product Description

  • A unique collection of 425 compounds targeting PI3K/Akt/mTOR signaling for research in PI3K/Akt/mTOR signaling, and drug discovery in diseases involved with PI3K/Akt/mTOR signaling;
  • Effective tool for studying cell growth, proliferation, and apoptosis;
  • Targets include AKT, AMPK, mTOR, PI3K, ATR/ATM, etc;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
Request Library Compound List (L1300)

Library Composition

PI3K (134)
mTOR (65)
Akt (56)
AMPK (50)
GSK-3 (40)
DNA-PK (31)
ATM/ATR (23)
S6 Kinase (22)
CDK (21)
PDK (13)
ERK (11)
Autophagy (9)
PKA (8)
Src (7)
Apoptosis (6)
VEGFR (6)
NF-κB (6)
PKC (6)
Chk (5)
Caspase (5)
FLT (5)
PDGFR (4)
SIK (4)
JNK (4)
MEK (4)
PTEN (4)
STAT (4)
COX (4)
MELK (3)
p38 MAPK (3)
Endogenous Metabolite (3)
IL Receptor (3)
Raf (3)
FGFR (2)
MMP (2)
MAPK (2)
Aurora Kinase (2)
PLK (2)
PPAR (2)
Potassium Channel (2)
Casein Kinase (2)
P450 (2)
Carbonic Anhydrase (2)
PDE (2)
Bcr-Abl (2)
transporter (2)
c-RET (2)
ROCK (2)
HIF (2)
Glucokinase (2)
HIV Protease (2)
PI4K (2)
AChR (2)
Trk receptor (1)
Topoisomerase (1)
Antiviral (1)
S1P Receptor (1)
Antioxidant (1)
TNF (1)
Serine Protease (1)
Tyrosinase (1)
SGK (1)
Adrenergic Receptor (1)
Tyrosine Kinases (1)
Antibacterial (1)
Prostaglandin Receptor (1)
ALK (1)
Sirtuin (1)
ATP Citrate Lyase (1)
P-gp (1)
DNA/RNA Synthesis (1)
Fatty Acid Synthase (1)
Estrogen/progestogen Receptor (1)
Epigenetic Reader Domain (1)
EGFR (1)
E1/E2/E3 Enzyme (1)
DYRK (1)
Dehydrogenase (1)
GluR (1)
c-Kit (1)
cholecystokinin (1)
c-Fms (1)
CaMK (1)
Calcium Channel (1)
BACE (1)
GABA Receptor (1)
Hck (1)
PARP (1)
Lipoxygenase (1)
Parasite (1)
Nrf2 (1)
NPC1L1 (1)
NOS (1)
NADPH (1)
LRRK2 (1)
LDL (1)
HCV Protease (1)
JAK (1)
IκB/IKK (1)
Integrin (1)
IGF-1R (1)
HSV (1)
HDAC (1)
Mitophagy (1)

Library Information Sample

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE