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ARS-1620

Catalog No. T7609Cas No. 1698055-85-4

ARS-1620 is a covalent inhibitor of K-RASG12C.

ARS-1620

ARS-1620

Catalog No. T7609Cas No. 1698055-85-4
ARS-1620 is a covalent inhibitor of K-RASG12C.
Pack SizePriceAvailabilityQuantity
1 mg$84In Stock
2 mg$119In Stock
5 mg$198In Stock
10 mg$289In Stock
25 mg$572In Stock
50 mg$822In Stock
100 mg$987In Stock
1 mL x 10 mM (in DMSO)$223In Stock
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Purity:≥95%
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Product Introduction

Bioactivity
Description
ARS-1620 is a covalent inhibitor of K-RASG12C.
In vivo
ARS-1620 (200 mg/kg) induces tumor regression in a MIA-PaCa2, but not an H441, mouse xenograft model.?It also decreases tumor volume in patient-derived xenograft (PDX) mouse models expressing K-RASG12C, but not K-RASG12D or wild-type K-RAS.
Chemical Properties
Molecular Weight430.84
FormulaC21H17ClF2N4O2
Cas No.1698055-85-4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 53 mg/mL (123.02 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3210 mL11.6052 mL23.2105 mL116.0524 mL
5 mM0.4642 mL2.3210 mL4.6421 mL23.2105 mL
10 mM0.2321 mL1.1605 mL2.3210 mL11.6052 mL
20 mM0.1161 mL0.5803 mL1.1605 mL5.8026 mL
50 mM0.0464 mL0.2321 mL0.4642 mL2.3210 mL
100 mM0.0232 mL0.1161 mL0.2321 mL1.1605 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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