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Thailanstatin A

Name: Thailanstatin A
Brand: TargetMol
SKU: T38889
Price: -1 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T38889Cas No. 1426953-21-0

Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing (IC50 = 650 nM). It inhibits multiple cancer cell lines via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the spliceosome, displaying low-nM to sub-nM IC50s. Thailanstatin A, as a payload for ADCs, is conjugated to the lysines on trastuzumab, yielding linker-less ADC.

Thailanstatin A

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Purity: 99.35%

Catalog No. T38889Cas No. 1426953-21-0

Pack Size	Price	Availability
1 mg	$197	In Stock
2 mg	$327	In Stock
5 mg	$579	In Stock
10 mg	$829	In Stock
25 mg	$1,270	In Stock
50 mg	Inquiry	In Stock

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Purity:99.35%

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COA HPLC

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Product Introduction

Bioactivity

Description	Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing (IC50 = 650 nM). It inhibits multiple cancer cell lines via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the spliceosome, displaying low-nM to sub-nM IC50s. Thailanstatin A, as a payload for ADCs, is conjugated to the lysines on trastuzumab, yielding linker-less ADC.
In vitro	Thailanstatin A (TST-A) is a potent antiproliferative natural product discovered by our group from Burkholderia thailandensis MSMB43 [2]. Thailanstatin A (DU-145, NCI-H232A, MDA-MB-231 and SKOV-3 cells) shows potent antiproliferative activities with GI 50 s in the single nM range (1.11-2.69 nM) [3].

Chemical Properties

Molecular Weight	535.63
Formula	C₂₈H₄₁NO₉
Cas No.	1426953-21-0
Smiles	C[C@H](OC(C)=O)\C=C/C(=O)N[C@@H]1C[C@H](C)[C@H](C\C=C(/C)\C=C\[C@H]2O[C@H](CC(O)=O)C[C@@]3(CO3)[C@@H]2O)O[C@@H]1C
Relative Density.	1.23 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 245 mg/mL (457.41 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8670 mL	9.3348 mL	18.6696 mL	93.3480 mL
5 mM	0.3734 mL	1.8670 mL	3.7339 mL	18.6696 mL
10 mM	0.1867 mL	0.9335 mL	1.8670 mL	9.3348 mL
20 mM	0.0933 mL	0.4667 mL	0.9335 mL	4.6674 mL
50 mM	0.0373 mL	0.1867 mL	0.3734 mL	1.8670 mL
100 mM	0.0187 mL	0.0933 mL	0.1867 mL	0.9335 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc